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• W2779407877 endingPage "498" @default.
• W2779407877 startingPage "481" @default.
• W2779407877 abstract "Gliomas are invasive brain tumors with high rates of recurrence and mortality. Glioblastoma multiforme (GBM) is the most deadly form of glioma with nearly 100% rate of recurrence and unfavorable prognosis in patients. Micro-RNAs (miR) are the class of wide-spread short non-coding RNAs that inhibit translation via binding to the mRNA of target genes. The aim of the present review is to analyze recent studies and experimental results concerning aberrant expression profiles of miR, which target components of the signaling pathways Hedgehog, Notch, Wnt, EGFR, TGFb, HIF1a in glioma/glioblastoma. Particularly, the interactions of miR with targets of 2-hydroxyglutarate (the product of mutant isocytrate dehydrogenase, R132H IDH1, which is specific for the glioma pathogenesis) have been considered in the present review. Detecting specific miRNAs in tissue and serum may serve as a diagnostic and prognostic tool for glioma, as well as for predicting treatment response of an individual patient, and potentially serving as a mechanism for creating personalized treatment strategies.Gliomy – invazivnye opukholi mozga, kharakterizuiushchiesia vysokimi urovniami retsidivirovaniia i smertnosti. Glioblastoma, kharakterizuiushchaiasia prakticheski 100%-nym retsidivirovaniem i neblagopriiatnym prognozom dlia patsientov, otnositsia k naibolee opasnym vidam gliom. Mikro-RNK (miR) – klass korotkikh nekodiruiushchikh RNK, sposobnykh ingibirovat' transliatsiiu putem targetnoĭ degradatsii mRNK. Tsel' nastoiashchego obzora – analiz issledovaniĭ i éksperimental'nykh rezul'tatov, kasaiushchikhsia kharakternykh dlia gliom/glioblastom izmeneniĭ profileĭ ékspressii mikro-RNK, misheniami kotorykh iavliaiutsia komponenty aberrantno reguliruemykh v gliomakh signal'nykh puteĭ Hedgehog, Notch, Wnt, EGFR, TGFb i HIF1a. Otdel'no rassmotreny sviazi mikro-RNK s misheniami 2-gidroksiglutarata, produkta mutantnoĭ izotsitratdegidrogenazy (R132H IDH1), mutatsionnye izmeneniia kotoroĭ iavliaiutsia spetsifichnymi dlia patogeneza gliom. Detektsiia opredelennykh vidov mikro-RNK v tkaniakh i syvorotke krovi mozhet ispol'zovat'sia dlia diagnostiki i prognoza, v tom chisle otveta konkretnogo patsienta na terapiiu, a takzhe dlia razrabotki novykh terapevticheskikh strategiĭ." @default.
• W2779407877 created "2018-01-05" @default.
• W2779407877 creator A5001229813 @default.
• W2779407877 creator A5011556547 @default.
• W2779407877 creator A5031972149 @default.
• W2779407877 creator A5039966717 @default.
• W2779407877 creator A5052728033 @default.
• W2779407877 date "2017-01-01" @default.
• W2779407877 modified "2023-10-17" @default.
• W2779407877 title "The role of micro-RNA in the regulation of signal pathways in gliomas" @default.
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