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• W2779454106 abstract "Carcinoembryonic antigen (CEA), a glycoprotein, is a wide-spectrum tumor marker for cancer diagnosis. Developing simple, stable, and low-cost methods for CEA detection is of great importance. In this work, a novel, label-free, and antibody-free electrochemical sandwich CEA biosensor was developed based on concanavalin A (ConA) and a DNA aptamer against CEA. Horse radish peroxidase (HRP) was labeled on the sandwich structure for signal production and amplification. Both the CEA and the HRP bind to ConA through sugar-lectin interactions. Under optimum conditions, the detection linear range was from 5 to 40 ng mL−1 CEA, with a detection limit of 3.4 ng mL−1, lower than the threshold level in human serum for cancer patients (∼10 ng mL−1). The biosensor is reproducible, accurate, specific, and stable, with RSD value of 3% for inter-biosensors, and relative error of <13% compared with those obtained by a commercial diagnostic kit. No obvious responses were observed toward interfering proteins. Storage did not cause obvious signal diminishment for the biosensor. The simple and low-cost aptasensor is promisingly applicable for CEA detection in cancer diagnosis, and could be able to serve as a general platform for detection of other interested glycoproteins." @default.
• W2779454106 created "2018-01-05" @default.
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• W2779454106 date "2018-05-01" @default.
• W2779454106 modified "2023-10-10" @default.
• W2779454106 title "A label-free and lectin-based sandwich aptasensor for detection of carcinoembryonic antigen" @default.
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• W2779454106 doi "https://doi.org/10.1016/j.snb.2017.12.105" @default.
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