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- W2779475057 abstract "Introduction: Omalizumab reduces asthma exacerbations in children with moderate-to-severe persistent asthma. There are few data on omalizumab efficacy by National Heart, Lung, and Blood Institute (NHLBI) asthma severity status. Methods: Children ≥6 to Results: The study enrolled 384 omalizumab and 192 placebo patients (years 2004-2008); most had severe asthma. During weeks 1-24, exacerbation rates declined 14% (rate ratio [RR; 95% CI]: 0.86 [0.52, 1.42]) in patients with moderate and 32% (RR: 0.68 [0.50, 0.92]) in those with severe persistent asthma. During weeks 1-52, exacerbation rates declined 35% (RR: 0.65 [0.43, 0.99]) in patients with moderate and 43% (RR: 0.57 [0.43, 0.75]) in those with severe persistent asthma (Table). Conclusions: Omalizumab reduces exacerbation rates at 24 and 52 weeks in moderate and severe asthma, and these benefits appear more pronounced with long (52 weeks) than short (24 weeks) treatment and in severe than moderate persistent asthma." @default.
- W2779475057 created "2018-01-05" @default.
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- W2779475057 date "2017-09-01" @default.
- W2779475057 modified "2023-09-27" @default.
- W2779475057 title "Omalizumab treatment reduces asthma exacerbations in children with moderate or severe persistent asthma" @default.
- W2779475057 doi "https://doi.org/10.1183/1393003.congress-2017.pa587" @default.
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