FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2779611209> ?p ?o ?g. }

• W2779611209 endingPage "28" @default.
• W2779611209 startingPage "23" @default.
• W2779611209 abstract "Clinical trials have demonstrated that 8 weeks of ledipasvir and sofosbuvir (LDV/SOF) achieved high rates of sustained virologic response at 12 weeks (SVR12) in patients with hepatitis C viral (HCV) genotype 1 infection. The effectiveness of this combination was noted to be robust in treatment-naive noncirrhotic patients and in patients with an HCV viral load of < 6 million IU/mL before treatment. Generalizability of these results to community clinical practice, however, was advised with caution due to the variability of staging methods, fluctuating nature of viral loads, lack of prospective trials, and real-life confirmation.To evaluate the efficacy, defined as SVR12, of LDV/SOF in a real-world setting.Patients met inclusion criteria if given 8 weeks of LDV/SOF by a specialty pharmacy from October 2014 to October 2015 and if SVR12 was assessed after therapy completion. Clinical outcomes data were obtained from the pharmacy database.Of the 6,391 prescriptions of LDV/SOF received by the pharmacy, 3,648 (57%) were covered by insurance, and among them, only 511 (14%) were for an 8-week regimen. SVR12 data were available for 380 (74%) patients who completed an 8-week regimen. 230 different prescribers wrote prescriptions, and 57 different insurance plans approved the 8-week regimen. The majority (74%) of patients were followed by gastroenterology clinics. The 380 patients included in the analysis were all treatment-naive HCV genotype 1 patients. Overall, SVR12 was achieved in 97% of patients, while 10 patients relapsed. The SVR12 rates were lower (93%) in patients with stage 3 fibrosis, particularly in African Americans (29 of 35: 83%).Outcomes were favorable for the 8-week use of LDV/SOF in a noncontrolled real-world setting in treatment-naive noncirrhotic patients with a baseline viral load < 6 million IU/mL. Use of this approach in African Americans with evidence of advanced fibrosis should be avoided.No outside funding supported this study. Lott is an employee of Diplomat Pharmacy. Andres and Qureshi have nothing to disclose. Study concept and design were contributed by Lott and Qureshi, who also collected the data. All authors contributed equally to data interpretation and manuscript preparation. Andres revised the manuscript, along with Lott and Qureshi. This work was presented in part as a poster at the 2016 International Liver Conference; Barcelona, Spain; April 13-17, 2016." @default.
• W2779611209 created "2018-01-05" @default.
• W2779611209 creator A5065629590 @default.
• W2779611209 creator A5072175110 @default.
• W2779611209 creator A5090382799 @default.
• W2779611209 date "2018-01-01" @default.
• W2779611209 modified "2023-09-25" @default.
• W2779611209 title "Eight-Week Outcomes of Ledipasvir/Sofosbuvir in Noncirrhotic Treatment-Naive Patients with Hepatitis C: Analysis of Pharmacy-Based Data" @default.
• W2779611209 cites W1977300462 @default.
• W2779611209 cites W1980154502 @default.
• W2779611209 cites W2017232326 @default.
• W2779611209 cites W2042063943 @default.
• W2779611209 cites W2045245188 @default.
• W2779611209 cites W2081897332 @default.
• W2779611209 cites W2142298409 @default.
• W2779611209 cites W2148840656 @default.
• W2779611209 cites W2156006417 @default.
• W2779611209 cites W2262571051 @default.
• W2779611209 cites W2288320856 @default.
• W2779611209 cites W2292090508 @default.
• W2779611209 cites W2416145228 @default.
• W2779611209 cites W2469405184 @default.
• W2779611209 cites W2520731166 @default.
• W2779611209 cites W2562480176 @default.
• W2779611209 cites W4211243282 @default.
• W2779611209 doi "https://doi.org/10.18553/jmcp.2018.24.1.23" @default.
• W2779611209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29290174" @default.
• W2779611209 hasPublicationYear "2018" @default.
• W2779611209 type Work @default.
• W2779611209 sameAs 2779611209 @default.
• W2779611209 citedByCount "5" @default.
• W2779611209 countsByYear W27796112092019 @default.
• W2779611209 countsByYear W27796112092020 @default.
• W2779611209 countsByYear W27796112092022 @default.
• W2779611209 crossrefType "journal-article" @default.
• W2779611209 hasAuthorship W2779611209A5065629590 @default.
• W2779611209 hasAuthorship W2779611209A5072175110 @default.
• W2779611209 hasAuthorship W2779611209A5090382799 @default.
• W2779611209 hasBestOaLocation W27796112091 @default.
• W2779611209 hasConcept C104863432 @default.
• W2779611209 hasConcept C126322002 @default.
• W2779611209 hasConcept C142462285 @default.
• W2779611209 hasConcept C187212893 @default.
• W2779611209 hasConcept C203014093 @default.
• W2779611209 hasConcept C2426938 @default.
• W2779611209 hasConcept C2522874641 @default.
• W2779611209 hasConcept C2775999097 @default.
• W2779611209 hasConcept C2776408679 @default.
• W2779611209 hasConcept C2776455275 @default.
• W2779611209 hasConcept C2778390639 @default.
• W2779611209 hasConcept C2780040827 @default.
• W2779611209 hasConcept C2781413609 @default.
• W2779611209 hasConcept C3013748606 @default.
• W2779611209 hasConcept C512399662 @default.
• W2779611209 hasConcept C535046627 @default.
• W2779611209 hasConcept C71924100 @default.
• W2779611209 hasConcept C98274493 @default.
• W2779611209 hasConceptScore W2779611209C104863432 @default.
• W2779611209 hasConceptScore W2779611209C126322002 @default.
• W2779611209 hasConceptScore W2779611209C142462285 @default.
• W2779611209 hasConceptScore W2779611209C187212893 @default.
• W2779611209 hasConceptScore W2779611209C203014093 @default.
• W2779611209 hasConceptScore W2779611209C2426938 @default.
• W2779611209 hasConceptScore W2779611209C2522874641 @default.
• W2779611209 hasConceptScore W2779611209C2775999097 @default.
• W2779611209 hasConceptScore W2779611209C2776408679 @default.
• W2779611209 hasConceptScore W2779611209C2776455275 @default.
• W2779611209 hasConceptScore W2779611209C2778390639 @default.
• W2779611209 hasConceptScore W2779611209C2780040827 @default.
• W2779611209 hasConceptScore W2779611209C2781413609 @default.
• W2779611209 hasConceptScore W2779611209C3013748606 @default.
• W2779611209 hasConceptScore W2779611209C512399662 @default.
• W2779611209 hasConceptScore W2779611209C535046627 @default.
• W2779611209 hasConceptScore W2779611209C71924100 @default.
• W2779611209 hasConceptScore W2779611209C98274493 @default.
• W2779611209 hasIssue "1" @default.
• W2779611209 hasLocation W27796112091 @default.
• W2779611209 hasLocation W27796112092 @default.
• W2779611209 hasOpenAccess W2779611209 @default.
• W2779611209 hasPrimaryLocation W27796112091 @default.
• W2779611209 hasRelatedWork W2116998649 @default.
• W2779611209 hasRelatedWork W2216086010 @default.
• W2779611209 hasRelatedWork W2336355105 @default.
• W2779611209 hasRelatedWork W2598167769 @default.
• W2779611209 hasRelatedWork W2969696875 @default.
• W2779611209 hasRelatedWork W3024700057 @default.
• W2779611209 hasRelatedWork W4206202184 @default.
• W2779611209 hasRelatedWork W4238202348 @default.
• W2779611209 hasRelatedWork W4245657394 @default.
• W2779611209 hasRelatedWork W4289815992 @default.
• W2779611209 hasVolume "24" @default.
• W2779611209 isParatext "false" @default.
• W2779611209 isRetracted "false" @default.
• W2779611209 magId "2779611209" @default.
• W2779611209 workType "article" @default.