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• W2779667543 abstract "// Bingxia Zhao 1, 2, * , Yihan Chen 1, 2, * , Jinfeng Liu 1, 2 , Li Zhang 1, 2 , Jing Wang 1, 2 , Yali Yang 1, 2 , Qing Lv 1, 2 and Mingxing Xie 1, 2 1 Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2 Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China * These authors contributed equally to this work Correspondence to: Mingxing Xie, email: xiemx@hust.edu.cn Keywords: blood-brain barrier; diagnostic ultrasound; microbubble; drug delivery Received: September 07, 2017      Accepted: December 04, 2017      Published: December 21, 2017 ABSTRACT Objective: To investigate the effects of the microbubble (MB) dose, mechanism index (MI) and sonication duration on blood-brain barrier (BBB) disruption induced by diagnostic ultrasound combined with MBs as well as to investigate the potential molecular mechanism. Results: The extent of BBB disruption increased with MB dose, MI and sonication duration. A relatively larger extent of BBB disruption associated with minimal tissue damage was achieved by an appropriate MB dose and ultrasound exposure parameters with diagnostic ultrasound. Decreased expression of ZO-1, occludin and claudin-5 were correlated with disruption of the BBB, as confirmed by paracellular passage of the tracer lanthanum nitrate into the brain parenchyma after BBB disruption. Conclusions: These findings indicated that this technique is a promising tool for promoting brain delivery of diagnostic and therapeutic agents in the diagnosis and treatment of brain diseases. Methods: The extent of BBB disruption was qualitatively assessed by Evans blue (EB) staining and quantitatively analyzed by an EB extravasation measurement. A histological examination was performed to evaluate tissue damage. Expression of tight junction (TJ) related proteins ZO-1, occludin and claudin-5 was determined by western blotting analysis and immunohistofluorescence. Transmission electron microscopy was performed to observe ultrastructure changes of TJs after BBB disruption." @default.
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• W2779667543 date "2017-12-21" @default.
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• W2779667543 title "Blood-brain barrier disruption induced by diagnostic ultrasound combined with microbubbles in mice" @default.
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• W2779667543 doi "https://doi.org/10.18632/oncotarget.23527" @default.
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