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- W2779837462 abstract "Objectives: Antiretroviral therapy (ART) has led to reduced pediatric HIV-associated mortality while at the same time is associated with liver toxicities that have not been well characterized in children below five years old. The aim of this study is to estimate the prevalence and correlates of elevated ALT levels at baseline and 24-months post-HAART.Material and Methods: Retrospective longitudinal study of HIV-infected infants aged 0-4.5 months participating in Optimizing Pediatric HAART(OPH03) clinical trial conducted in Kenyatta National between 2007 and 2009. We evaluated serum alanine transaminase (ALT) levels in newly diagnosed HIV-1 infected infants initiated on ART within a previously described randomized trial. Children were seen at monthly intervals for clinical assessment, physical examination and anthropometry.Statistical analysis: Linear regression models were used to determine factors associated with elevated ALT. Variables with p-values ≤0.2 in the unadjusted model were included in the final multivariate model.Results: Among 99 enrolled infants, median age pre-HAART was 3.7 months, CD4% was 18%, and weight-for-age z-score (WAZ) was -2.51. Pre-HAART median ALT was 31.1IU/L, 25.0% had elevated ALT (≥42 IU/L). Lower pre-HAART HDL and older age were each associated with higher pre-HAART ALT (P=0.028 and P=0.019). Birth weight and Protease inhibitor (PI) - HAART were significantly associated with a median decrease in ALT levels (P=0.015 and P=0.045). Increased change in ALT was associated with WHO stage III/IV disease (P=0.050).Conclusions: Prevalence of elevated ALT in our cohort was low and stable across the study." @default.
- W2779837462 created "2018-01-05" @default.
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- W2779837462 date "2017-12-11" @default.
- W2779837462 modified "2023-09-26" @default.
- W2779837462 title "Predictors of Elevated Alanine Transaminase Levels (ALT) in HIV-infected Infants on HAART in Nairobi, Kenya" @default.
- W2779837462 doi "https://doi.org/10.24087/iam.2018.2.1.373" @default.
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