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• W2779934823 abstract "Pharmacogenetic tests are being used increasingly to prevent rare and potentially life-threatening adverse drug reactions. For many tests, however, cost-effectiveness is hard to demonstrate, and with the exception of a few cases, widespread implementation remains a distant prospect. Many orphan drugs for rare diseases are also not cost effective but are nonetheless normally reimbursed. In this article, we argue that the health technology assessment of pharmacogenetic tests aimed to prevent rare but severe adverse drug reactions should be on a level playing field with orphan drugs. This is supported by a number of arguments, concerning the severity, rarity and iatrogenic nature of adverse drug reactions, the distribution of benefits and costs and societal preference towards prevention over treatment." @default.
• W2779934823 created "2018-01-05" @default.
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• W2779934823 date "2018-02-01" @default.
• W2779934823 modified "2023-09-23" @default.
• W2779934823 title "Rare disease prevention and treatment: the need for a level playing field" @default.
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• W2779934823 doi "https://doi.org/10.2217/pgs-2017-0300" @default.
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• W2779934823 hasPublicationYear "2018" @default.
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