FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2779968640> ?p ?o ?g. }

• W2779968640 endingPage "1343" @default.
• W2779968640 startingPage "1337" @default.
• W2779968640 abstract "Abstract Purpose: We sought to investigate the clinical response to MET inhibition in patients diagnosed with structural MET alterations and to characterize their functional relevance in cellular models. Experimental Design: Patients were selected for treatment with crizotinib upon results of hybrid capture–based next-generation sequencing. To confirm the clinical observations, we analyzed cellular models that express these MET kinase alterations. Results: Three individual patients were identified to harbor alterations within the MET receptor. Two patients showed genomic rearrangements, leading to a gene fusion of KIF5B or STARD3NL and MET. One patient diagnosed with an EML4-ALK rearrangement developed a MET kinase domain duplication as a resistance mechanism to ceritinib. All 3 patients showed a partial response to crizotinib that effectively inhibits MET and ALK among other kinases. The results were further confirmed using orthogonal cellular models. Conclusions: Crizotinib leads to a clinical response in patients with MET rearrangements. Our functional analyses together with the clinical data suggest that these structural alterations may represent actionable targets in lung cancer patients. Clin Cancer Res; 24(6); 1337–43. ©2017 AACR." @default.
• W2779968640 created "2018-01-05" @default.
• W2779968640 creator A5006712577 @default.
• W2779968640 creator A5008015466 @default.
• W2779968640 creator A5014839908 @default.
• W2779968640 creator A5015051535 @default.
• W2779968640 creator A5016801550 @default.
• W2779968640 creator A5025511599 @default.
• W2779968640 creator A5027301625 @default.
• W2779968640 creator A5043225036 @default.
• W2779968640 creator A5048117410 @default.
• W2779968640 creator A5050607074 @default.
• W2779968640 creator A5052066844 @default.
• W2779968640 creator A5052962511 @default.
• W2779968640 creator A5053252307 @default.
• W2779968640 creator A5053700204 @default.
• W2779968640 creator A5055111767 @default.
• W2779968640 creator A5056803492 @default.
• W2779968640 creator A5062909275 @default.
• W2779968640 creator A5066714040 @default.
• W2779968640 creator A5067754981 @default.
• W2779968640 creator A5070273513 @default.
• W2779968640 creator A5071459483 @default.
• W2779968640 creator A5075942051 @default.
• W2779968640 creator A5077495488 @default.
• W2779968640 creator A5086985238 @default.
• W2779968640 date "2018-03-14" @default.
• W2779968640 modified "2023-10-02" @default.
• W2779968640 title "Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients" @default.
• W2779968640 cites W1981083257 @default.
• W2779968640 cites W1989448072 @default.
• W2779968640 cites W1993801118 @default.
• W2779968640 cites W1998971866 @default.
• W2779968640 cites W2004202575 @default.
• W2779968640 cites W2038056960 @default.
• W2779968640 cites W2053343049 @default.
• W2779968640 cites W2065799563 @default.
• W2779968640 cites W2071480068 @default.
• W2779968640 cites W2081157104 @default.
• W2779968640 cites W2101441514 @default.
• W2779968640 cites W2104830962 @default.
• W2779968640 cites W2146810218 @default.
• W2779968640 cites W2155263737 @default.
• W2779968640 cites W2169624569 @default.
• W2779968640 cites W2180481128 @default.
• W2779968640 cites W2212335550 @default.
• W2779968640 cites W2413097448 @default.
• W2779968640 cites W2424133004 @default.
• W2779968640 cites W2533448509 @default.
• W2779968640 cites W2588554885 @default.
• W2779968640 cites W2625091344 @default.
• W2779968640 doi "https://doi.org/10.1158/1078-0432.ccr-17-3001" @default.
• W2779968640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29284707" @default.
• W2779968640 hasPublicationYear "2018" @default.
• W2779968640 type Work @default.
• W2779968640 sameAs 2779968640 @default.
• W2779968640 citedByCount "64" @default.
• W2779968640 countsByYear W27799686402018 @default.
• W2779968640 countsByYear W27799686402019 @default.
• W2779968640 countsByYear W27799686402020 @default.
• W2779968640 countsByYear W27799686402021 @default.
• W2779968640 countsByYear W27799686402022 @default.
• W2779968640 countsByYear W27799686402023 @default.
• W2779968640 crossrefType "journal-article" @default.
• W2779968640 hasAuthorship W2779968640A5006712577 @default.
• W2779968640 hasAuthorship W2779968640A5008015466 @default.
• W2779968640 hasAuthorship W2779968640A5014839908 @default.
• W2779968640 hasAuthorship W2779968640A5015051535 @default.
• W2779968640 hasAuthorship W2779968640A5016801550 @default.
• W2779968640 hasAuthorship W2779968640A5025511599 @default.
• W2779968640 hasAuthorship W2779968640A5027301625 @default.
• W2779968640 hasAuthorship W2779968640A5043225036 @default.
• W2779968640 hasAuthorship W2779968640A5048117410 @default.
• W2779968640 hasAuthorship W2779968640A5050607074 @default.
• W2779968640 hasAuthorship W2779968640A5052066844 @default.
• W2779968640 hasAuthorship W2779968640A5052962511 @default.
• W2779968640 hasAuthorship W2779968640A5053252307 @default.
• W2779968640 hasAuthorship W2779968640A5053700204 @default.
• W2779968640 hasAuthorship W2779968640A5055111767 @default.
• W2779968640 hasAuthorship W2779968640A5056803492 @default.
• W2779968640 hasAuthorship W2779968640A5062909275 @default.
• W2779968640 hasAuthorship W2779968640A5066714040 @default.
• W2779968640 hasAuthorship W2779968640A5067754981 @default.
• W2779968640 hasAuthorship W2779968640A5070273513 @default.
• W2779968640 hasAuthorship W2779968640A5071459483 @default.
• W2779968640 hasAuthorship W2779968640A5075942051 @default.
• W2779968640 hasAuthorship W2779968640A5077495488 @default.
• W2779968640 hasAuthorship W2779968640A5086985238 @default.
• W2779968640 hasConcept C104317684 @default.
• W2779968640 hasConcept C117643217 @default.
• W2779968640 hasConcept C121608353 @default.
• W2779968640 hasConcept C126322002 @default.
• W2779968640 hasConcept C143065580 @default.
• W2779968640 hasConcept C143998085 @default.
• W2779968640 hasConcept C184235292 @default.
• W2779968640 hasConcept C2776232967 @default.
• W2779968640 hasConcept C2776256026 @default.
• W2779968640 hasConcept C2779422266 @default.

• next