FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780093346> ?p ?o ?g. }

• W2780093346 endingPage "71" @default.
• W2780093346 startingPage "65" @default.
• W2780093346 abstract "Osteon Myospalacem Baileyi, known as Sai long gu (Tibetan language, means “blind rat bone”), is the whole skeleton of Tibet plateau rodentia animal Myospalacem Baileyi. Osteon Myospalacem Baileyi had been widely used in the Tibet region as an anti-osteoporosis drug and since 1991 Osteon Myospalacem Baileyi has been listed in the Pharmacopoeia of People's Republic of China as the first-class animal new medical material. However, the mechanism of its anti-osteoporosis activities is still unclear. It is very desirable to solve this problem for further study. in this study, preparative chromatography was employed to produce the active fraction ET4 from Osteon Myospalacem Baileyi crude. Flow cytometry and MTT assay were used to evaluate the toxicities of ET4. BMM cells were separated from mouse bone marrow to test the inhibition effects of ET4 on osteoclastogenesis. Western blot was used to find out the pathways, through which ET4 could act on osteoclastogenesis. Q-PCR was used to test the osteoclastogenesis marker genes. At last, immunofluorescence confocal microscopy was used to test the osteoclastogenesis master protein NFATc1 nuclei translocation. In this study we report that ET4, at the dose of 60 μg/mL, significantly inhibited the formation of osteoclasts. Notably, ET4 did not affect the BMM viability at that dose. In addition, Osteon Myospalacem Baileyi could inhibit the expression of osteoclast marker genes, including cathepsin K (CTSK), nuclear factor of activated T cells cytoplasmic 1 (NFATc1), tartrate resistant acid phosphatase (TRAP, Acp5) dendrite cell-specific transmembrane protein (DC-STAMP), calcitonin receptor (CTR), osteoclast associated and immunoglobulin-like receptor (OSCAR). Mechanistically, ET4 dose- and time-dependently blocked the RANKL-induced activation of ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. These data suggest that ET4 might be a useful alternative therapy in preventing or treating osteolytic diseases." @default.
• W2780093346 created "2018-01-05" @default.
• W2780093346 creator A5008300440 @default.
• W2780093346 creator A5016948160 @default.
• W2780093346 creator A5022030035 @default.
• W2780093346 creator A5044318950 @default.
• W2780093346 creator A5051434566 @default.
• W2780093346 creator A5059024560 @default.
• W2780093346 creator A5073144711 @default.
• W2780093346 creator A5073742261 @default.
• W2780093346 creator A5074633684 @default.
• W2780093346 date "2018-03-01" @default.
• W2780093346 modified "2023-10-18" @default.
• W2780093346 title "Osteon Myospalacem Baileyi attenuates osteoclast differentiation through RANKL induced NFAT pathways" @default.
• W2780093346 cites W1855284372 @default.
• W2780093346 cites W1866200213 @default.
• W2780093346 cites W2008265399 @default.
• W2780093346 cites W2112690571 @default.
• W2780093346 cites W2118149891 @default.
• W2780093346 cites W2254510206 @default.
• W2780093346 cites W2282302313 @default.
• W2780093346 cites W2288564600 @default.
• W2780093346 cites W2468601872 @default.
• W2780093346 cites W2474102470 @default.
• W2780093346 cites W4211224208 @default.
• W2780093346 doi "https://doi.org/10.1016/j.jep.2017.10.007" @default.
• W2780093346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29107144" @default.
• W2780093346 hasPublicationYear "2018" @default.
• W2780093346 type Work @default.
• W2780093346 sameAs 2780093346 @default.
• W2780093346 citedByCount "5" @default.
• W2780093346 countsByYear W27800933462018 @default.
• W2780093346 countsByYear W27800933462021 @default.
• W2780093346 countsByYear W27800933462022 @default.
• W2780093346 crossrefType "journal-article" @default.
• W2780093346 hasAuthorship W2780093346A5008300440 @default.
• W2780093346 hasAuthorship W2780093346A5016948160 @default.
• W2780093346 hasAuthorship W2780093346A5022030035 @default.
• W2780093346 hasAuthorship W2780093346A5044318950 @default.
• W2780093346 hasAuthorship W2780093346A5051434566 @default.
• W2780093346 hasAuthorship W2780093346A5059024560 @default.
• W2780093346 hasAuthorship W2780093346A5073144711 @default.
• W2780093346 hasAuthorship W2780093346A5073742261 @default.
• W2780093346 hasAuthorship W2780093346A5074633684 @default.
• W2780093346 hasConcept C101990758 @default.
• W2780093346 hasConcept C105702510 @default.
• W2780093346 hasConcept C118303440 @default.
• W2780093346 hasConcept C126322002 @default.
• W2780093346 hasConcept C134018914 @default.
• W2780093346 hasConcept C153911025 @default.
• W2780093346 hasConcept C163170386 @default.
• W2780093346 hasConcept C170033053 @default.
• W2780093346 hasConcept C170493617 @default.
• W2780093346 hasConcept C180675623 @default.
• W2780093346 hasConcept C203014093 @default.
• W2780093346 hasConcept C2776033226 @default.
• W2780093346 hasConcept C2777909254 @default.
• W2780093346 hasConcept C2779428903 @default.
• W2780093346 hasConcept C2779627488 @default.
• W2780093346 hasConcept C2781451080 @default.
• W2780093346 hasConcept C553184892 @default.
• W2780093346 hasConcept C55493867 @default.
• W2780093346 hasConcept C673006 @default.
• W2780093346 hasConcept C71924100 @default.
• W2780093346 hasConcept C86803240 @default.
• W2780093346 hasConcept C88045685 @default.
• W2780093346 hasConcept C92316933 @default.
• W2780093346 hasConcept C95444343 @default.
• W2780093346 hasConceptScore W2780093346C101990758 @default.
• W2780093346 hasConceptScore W2780093346C105702510 @default.
• W2780093346 hasConceptScore W2780093346C118303440 @default.
• W2780093346 hasConceptScore W2780093346C126322002 @default.
• W2780093346 hasConceptScore W2780093346C134018914 @default.
• W2780093346 hasConceptScore W2780093346C153911025 @default.
• W2780093346 hasConceptScore W2780093346C163170386 @default.
• W2780093346 hasConceptScore W2780093346C170033053 @default.
• W2780093346 hasConceptScore W2780093346C170493617 @default.
• W2780093346 hasConceptScore W2780093346C180675623 @default.
• W2780093346 hasConceptScore W2780093346C203014093 @default.
• W2780093346 hasConceptScore W2780093346C2776033226 @default.
• W2780093346 hasConceptScore W2780093346C2777909254 @default.
• W2780093346 hasConceptScore W2780093346C2779428903 @default.
• W2780093346 hasConceptScore W2780093346C2779627488 @default.
• W2780093346 hasConceptScore W2780093346C2781451080 @default.
• W2780093346 hasConceptScore W2780093346C553184892 @default.
• W2780093346 hasConceptScore W2780093346C55493867 @default.
• W2780093346 hasConceptScore W2780093346C673006 @default.
• W2780093346 hasConceptScore W2780093346C71924100 @default.
• W2780093346 hasConceptScore W2780093346C86803240 @default.
• W2780093346 hasConceptScore W2780093346C88045685 @default.
• W2780093346 hasConceptScore W2780093346C92316933 @default.
• W2780093346 hasConceptScore W2780093346C95444343 @default.
• W2780093346 hasFunder F4320321001 @default.
• W2780093346 hasFunder F4320321133 @default.
• W2780093346 hasFunder F4320321885 @default.
• W2780093346 hasFunder F4320335921 @default.
• W2780093346 hasLocation W27800933461 @default.
• W2780093346 hasLocation W27800933462 @default.

• next