FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780117220> ?p ?o ?g. }

• W2780117220 endingPage "6244" @default.
• W2780117220 startingPage "6238" @default.
• W2780117220 abstract "High levels of heparanase are detected in many types of tumors, associated with bad prognosis. Typically, heparanase levels are evaluated in a biopsy taken from the primary lesion, whereas its expression by the resulting metastases is most often unresolved. This becomes critically important as anti-heparanase compounds enter advanced clinical trials. Here, we examined the expression of heparanase in pairs of primary and the resulting distant metastases of breast carcinoma. Interestingly, we found that heparanase expression in the metastatic lesion does not always reflect its expression in the primary tumor. Accordingly, in some cases, the primary lesion was stained positive for heparanase while the metastasis stained negative, and vice versa. Heparanase discordance occurred in 38% of the patients, higher than that reported for hormone receptors, and was associated with bad prognosis. Thus, examination of heparanase levels in the tumor metastases should be evaluated for most efficient precision medicine applying heparanase inhibitors. Furthermore, we found that in stage I breast cancer patients strong heparanase staining is associated with shorter overall survival. Thus, heparanase levels can assist in the diagnosis and in determining the necessity and type of treatment in early stage breast cancer." @default.
• W2780117220 created "2018-01-05" @default.
• W2780117220 creator A5037824025 @default.
• W2780117220 creator A5044146429 @default.
• W2780117220 creator A5047547446 @default.
• W2780117220 creator A5051815910 @default.
• W2780117220 creator A5065401593 @default.
• W2780117220 creator A5070627238 @default.
• W2780117220 creator A5088349668 @default.
• W2780117220 creator A5089977935 @default.
• W2780117220 date "2017-12-21" @default.
• W2780117220 modified "2023-10-16" @default.
• W2780117220 title "Prognostic significance of heparanase expression in primary and metastatic breast carcinoma" @default.
• W2780117220 cites W1502893100 @default.
• W2780117220 cites W1961026612 @default.
• W2780117220 cites W1976218313 @default.
• W2780117220 cites W1979225185 @default.
• W2780117220 cites W1991286340 @default.
• W2780117220 cites W1997613697 @default.
• W2780117220 cites W2001718789 @default.
• W2780117220 cites W2009962397 @default.
• W2780117220 cites W2022532273 @default.
• W2780117220 cites W2033039805 @default.
• W2780117220 cites W2038276233 @default.
• W2780117220 cites W2044702943 @default.
• W2780117220 cites W2063874882 @default.
• W2780117220 cites W2083031183 @default.
• W2780117220 cites W2089542655 @default.
• W2780117220 cites W2100864793 @default.
• W2780117220 cites W2105882193 @default.
• W2780117220 cites W2115813710 @default.
• W2780117220 cites W2121179180 @default.
• W2780117220 cites W2127473093 @default.
• W2780117220 cites W2132120901 @default.
• W2780117220 cites W2134709252 @default.
• W2780117220 cites W2159154148 @default.
• W2780117220 cites W2160377567 @default.
• W2780117220 cites W2170602872 @default.
• W2780117220 cites W2230036385 @default.
• W2780117220 cites W2235523093 @default.
• W2780117220 cites W2308277321 @default.
• W2780117220 cites W2338403880 @default.
• W2780117220 cites W2468868288 @default.
• W2780117220 cites W2529270648 @default.
• W2780117220 cites W2560635244 @default.
• W2780117220 cites W2598884823 @default.
• W2780117220 cites W2741181091 @default.
• W2780117220 cites W2754711591 @default.
• W2780117220 cites W3016908890 @default.
• W2780117220 doi "https://doi.org/10.18632/oncotarget.23560" @default.
• W2780117220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5814208" @default.
• W2780117220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29464068" @default.
• W2780117220 hasPublicationYear "2017" @default.
• W2780117220 type Work @default.
• W2780117220 sameAs 2780117220 @default.
• W2780117220 citedByCount "16" @default.
• W2780117220 countsByYear W27801172202018 @default.
• W2780117220 countsByYear W27801172202019 @default.
• W2780117220 countsByYear W27801172202020 @default.
• W2780117220 countsByYear W27801172202021 @default.
• W2780117220 countsByYear W27801172202022 @default.
• W2780117220 countsByYear W27801172202023 @default.
• W2780117220 crossrefType "journal-article" @default.
• W2780117220 hasAuthorship W2780117220A5037824025 @default.
• W2780117220 hasAuthorship W2780117220A5044146429 @default.
• W2780117220 hasAuthorship W2780117220A5047547446 @default.
• W2780117220 hasAuthorship W2780117220A5051815910 @default.
• W2780117220 hasAuthorship W2780117220A5065401593 @default.
• W2780117220 hasAuthorship W2780117220A5070627238 @default.
• W2780117220 hasAuthorship W2780117220A5088349668 @default.
• W2780117220 hasAuthorship W2780117220A5089977935 @default.
• W2780117220 hasBestOaLocation W27801172201 @default.
• W2780117220 hasConcept C121608353 @default.
• W2780117220 hasConcept C126322002 @default.
• W2780117220 hasConcept C142724271 @default.
• W2780117220 hasConcept C143998085 @default.
• W2780117220 hasConcept C146357865 @default.
• W2780117220 hasConcept C151730666 @default.
• W2780117220 hasConcept C204232928 @default.
• W2780117220 hasConcept C2777478136 @default.
• W2780117220 hasConcept C2779013556 @default.
• W2780117220 hasConcept C2781156865 @default.
• W2780117220 hasConcept C3018521938 @default.
• W2780117220 hasConcept C502942594 @default.
• W2780117220 hasConcept C530470458 @default.
• W2780117220 hasConcept C71924100 @default.
• W2780117220 hasConcept C86803240 @default.
• W2780117220 hasConceptScore W2780117220C121608353 @default.
• W2780117220 hasConceptScore W2780117220C126322002 @default.
• W2780117220 hasConceptScore W2780117220C142724271 @default.
• W2780117220 hasConceptScore W2780117220C143998085 @default.
• W2780117220 hasConceptScore W2780117220C146357865 @default.
• W2780117220 hasConceptScore W2780117220C151730666 @default.
• W2780117220 hasConceptScore W2780117220C204232928 @default.
• W2780117220 hasConceptScore W2780117220C2777478136 @default.
• W2780117220 hasConceptScore W2780117220C2779013556 @default.
• W2780117220 hasConceptScore W2780117220C2781156865 @default.
• W2780117220 hasConceptScore W2780117220C3018521938 @default.

• next