Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780217766> ?p ?o ?g. }
- W2780217766 endingPage "87" @default.
- W2780217766 startingPage "74" @default.
- W2780217766 abstract "Convection enhanced delivery (CED) of chemotherapeutic drugs can successfully bypass the blood-brain barrier (BBB). However, the treatment efficacy is significantly variable in clinic owing to the absence of proper drugs and the lack of understanding on the local drug transport. In this study, mathematical modelling is employed to investigate the suitability of six chemotherapeutic drugs from the perspective of intratumoural transport, including fluorouracil, carmustine, cisplatin, methotrexate, doxorubicin and paclitaxel. The convection/diffusion/reaction model coupled with Darcy's law is applied to a 3-D realistic brain tumour model that is extracted from magnetic resonance (MR) images. The modelling demonstrates the advantages of CED in enhancing the convective flow of interstitial fluid and reducing the drug concentration dilution caused by the fluid loss from blood stream in the tumour region around the infusion site. The delivery outcomes of the drug in CED treatments are strongly dependent on its physicochemical properties. Convection is more effective in determining the transport of paclitaxel and methotrexate in brain tumour. Paclitaxel exhibits its superiority in drug penetration and accumulation, resulting in the largest effective delivery volume as compared to the other studied drugs. Nanocarrier and diagnostic ultrasound are able to enhance the drug penetration for achieving improved delivery outcomes. Results obtained in this study can serve as a guide for optimising CED treatment regimens." @default.
- W2780217766 created "2018-01-05" @default.
- W2780217766 creator A5004160453 @default.
- W2780217766 creator A5043894683 @default.
- W2780217766 date "2018-02-01" @default.
- W2780217766 modified "2023-10-16" @default.
- W2780217766 title "Convection enhanced delivery of chemotherapeutic drugs into brain tumour" @default.
- W2780217766 cites W1966075252 @default.
- W2780217766 cites W1968612832 @default.
- W2780217766 cites W1970827103 @default.
- W2780217766 cites W1974189322 @default.
- W2780217766 cites W1978004290 @default.
- W2780217766 cites W1981517535 @default.
- W2780217766 cites W1982369490 @default.
- W2780217766 cites W1982435395 @default.
- W2780217766 cites W1994067875 @default.
- W2780217766 cites W1994183414 @default.
- W2780217766 cites W2003890250 @default.
- W2780217766 cites W2013166662 @default.
- W2780217766 cites W2014220492 @default.
- W2780217766 cites W2016864853 @default.
- W2780217766 cites W2022494564 @default.
- W2780217766 cites W2023409962 @default.
- W2780217766 cites W2030009788 @default.
- W2780217766 cites W2030953740 @default.
- W2780217766 cites W2031364138 @default.
- W2780217766 cites W2035419569 @default.
- W2780217766 cites W2038500691 @default.
- W2780217766 cites W2042007311 @default.
- W2780217766 cites W2050771499 @default.
- W2780217766 cites W2051491231 @default.
- W2780217766 cites W205461530 @default.
- W2780217766 cites W2058144880 @default.
- W2780217766 cites W2061372618 @default.
- W2780217766 cites W2061956672 @default.
- W2780217766 cites W2062499970 @default.
- W2780217766 cites W2066724170 @default.
- W2780217766 cites W2067251428 @default.
- W2780217766 cites W2069865317 @default.
- W2780217766 cites W2070248960 @default.
- W2780217766 cites W2070514296 @default.
- W2780217766 cites W2071551353 @default.
- W2780217766 cites W2075942518 @default.
- W2780217766 cites W2078523778 @default.
- W2780217766 cites W2082870228 @default.
- W2780217766 cites W2083280522 @default.
- W2780217766 cites W2083927153 @default.
- W2780217766 cites W2088473419 @default.
- W2780217766 cites W2091256503 @default.
- W2780217766 cites W2098317320 @default.
- W2780217766 cites W2099431752 @default.
- W2780217766 cites W2105060883 @default.
- W2780217766 cites W2106893957 @default.
- W2780217766 cites W2111498289 @default.
- W2780217766 cites W2120977461 @default.
- W2780217766 cites W2125109412 @default.
- W2780217766 cites W2143203694 @default.
- W2780217766 cites W2151153669 @default.
- W2780217766 cites W2157084699 @default.
- W2780217766 cites W2165430984 @default.
- W2780217766 cites W2169613628 @default.
- W2780217766 cites W2170146596 @default.
- W2780217766 cites W2204996528 @default.
- W2780217766 cites W2318414535 @default.
- W2780217766 cites W2319766044 @default.
- W2780217766 cites W2333399485 @default.
- W2780217766 cites W2470001571 @default.
- W2780217766 cites W2489246047 @default.
- W2780217766 cites W2531640839 @default.
- W2780217766 cites W2560711747 @default.
- W2780217766 cites W2583981323 @default.
- W2780217766 cites W2587991154 @default.
- W2780217766 cites W2594625701 @default.
- W2780217766 cites W2611637941 @default.
- W2780217766 cites W2719234611 @default.
- W2780217766 cites W307243146 @default.
- W2780217766 cites W67938392 @default.
- W2780217766 doi "https://doi.org/10.1016/j.jconrel.2017.12.020" @default.
- W2780217766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29274437" @default.
- W2780217766 hasPublicationYear "2018" @default.
- W2780217766 type Work @default.
- W2780217766 sameAs 2780217766 @default.
- W2780217766 citedByCount "49" @default.
- W2780217766 countsByYear W27802177662018 @default.
- W2780217766 countsByYear W27802177662019 @default.
- W2780217766 countsByYear W27802177662020 @default.
- W2780217766 countsByYear W27802177662021 @default.
- W2780217766 countsByYear W27802177662022 @default.
- W2780217766 countsByYear W27802177662023 @default.
- W2780217766 crossrefType "journal-article" @default.
- W2780217766 hasAuthorship W2780217766A5004160453 @default.
- W2780217766 hasAuthorship W2780217766A5043894683 @default.
- W2780217766 hasConcept C112705442 @default.
- W2780217766 hasConcept C126511603 @default.
- W2780217766 hasConcept C141071460 @default.
- W2780217766 hasConcept C178790620 @default.
- W2780217766 hasConcept C18150654 @default.
- W2780217766 hasConcept C185592680 @default.