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- W2780245101 abstract "Background: Pulmonary Langerhans Cell Histiocytosis (PLCH) is a diffuse cystic disease associated with reduced exercise capacity. However, the mechanisms involved in exercise limitation in PLCH are not completely understood. Objectives: To evaluate exercise performance and the main mechanisms of exercise limitation in PLCH. Methods: A cross-sectional study that evaluated 25 patients with PLCH (32% men, age 44 ± 9 years, 72% former or current smokers, with baseline dyspnea index 7 ± 3) underwent echocardiogram, six minute walk test (6MWT), pulmonary functions tests and incremental cardiopulmonary exercise test (CPET) on treadmill, with evaluation of dynamic hyperinflation. Results: Echocardiography suggested pulmonary hypertension in 67% of patients (tricuspid regurgitant jet velocity was 3.08 ± 0.78 m/s). The distance walked was 449 ± 93 m. FEV1 was 62 ± 21%, RV/TLC was 43 ± 11 and DLCO was 55 ± 23%. An obstructive pattern, air trapping and reduced DLCO were found in 76%, 36% and 76%, respectively. Maximal oxygen consumption was 88 ± 24% of predicted, and was reduced in half of patients. Ventilatory limitation, pulmonary hypertension (PH), dynamic hyperinflation and oxygen desaturation were identified in 36%, 23%, 66% and 73% of patients, respectively, during exercise, and most patients had more than one mechanism involved. Conclusions: Reduced exercise capacity is common among PLCH patients and is mainly associated with gas exchange impairment, ventilatory limitation, dynamic hyperinflation and PH, frequently with multifactorial involvement. Financial support: FAPESP (Sao Paulo Research Foundation), grant 2015/06604-0" @default.
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- W2780245101 date "2017-09-01" @default.
- W2780245101 modified "2023-09-26" @default.
- W2780245101 title "Exercise in patients with pulmonary Langerhans cell histiocytosis: performance and mechanisms of limitation" @default.
- W2780245101 doi "https://doi.org/10.1183/1393003.congress-2017.oa4640" @default.
- W2780245101 hasPublicationYear "2017" @default.
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