Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780276291> ?p ?o ?g. }
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- W2780276291 startingPage "9" @default.
- W2780276291 abstract "Aberrant profiles of pre-mRNA splicing are frequently observed in cancer. At the molecular level, an altered profile results from a complex interplay between chromatin modifications, the transcriptional elongation rate of RNA polymerase, and effective binding of the spliceosome to the generated transcripts. Key players in this interplay are regulatory splicing factors (SFs) that bind to gene-specific splice-regulatory sequence elements. Although mutations in genes of some SFs were described, a major driver of aberrant splicing profiles is oncogenic signal transduction pathways. Signaling can affect either the transcriptional expression levels of SFs or the post-translational modification of SF proteins, and both modulate the ratio of nuclear versus cytoplasmic SFs in a given cell. Here, we will review currently known mechanisms by which cancer cell signaling, including the mitogen-activated protein kinases (MAPK), phosphatidylinositol 3 (PI3)-kinase pathway (PI3K) and wingless (Wnt) pathways but also signals from the tumor microenvironment, modulate the activity or subcellular localization of the Ser/Arg rich (SR) proteins and heterogeneous nuclear ribonucleoproteins (hnRNPs) families of SFs." @default.
- W2780276291 created "2018-01-05" @default.
- W2780276291 creator A5055974817 @default.
- W2780276291 creator A5058818812 @default.
- W2780276291 creator A5083491767 @default.
- W2780276291 date "2017-12-29" @default.
- W2780276291 modified "2023-09-27" @default.
- W2780276291 title "Signaling Pathways Driving Aberrant Splicing in Cancer Cells" @default.
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