FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780291211> ?p ?o ?g. }

• W2780291211 endingPage "279" @default.
• W2780291211 startingPage "271" @default.
• W2780291211 abstract "Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are associated with a variety of cellular alterations that mitigate cardiovascular disease. However, pinpointing the positive therapeutic effects is challenging due to inconsistent clinical trial results and overly simplistic in vitro studies. Here we aimed to develop realistic models of n-3 PUFA effects on platelet function so that preclinical results can better align with and predict clinical outcomes. Human platelets incubated with the n-3 PUFAs docosahexaenoic acid and eicosapentaenoic acid were stimulated with agonist combinations mirroring distinct regions of a growing thrombus. Platelet responses were then monitored in a number of ex-vivo functional assays. Furthermore, intravital microscopy was used to monitor arterial thrombosis and fibrin deposition in mice fed an n-3 PUFA-enriched diet. We found that n-3 PUFA treatment had minimal effects on many basic ex-vivo measures of platelet function using agonist combinations. However, n-3 PUFA treatment delayed platelet-derived thrombin generation in both humans and mice. This impaired thrombin production paralleled a reduced platelet accumulation within thrombi formed in either small arterioles or larger arteries of mice fed an n-3 PUFA-enriched diet, without impacting P-selectin exposure. Despite an apparent lack of robust effects in many ex-vivo assays of platelet function, increased exposure to n-3 PUFAs reduces platelet-mediated thrombin generation and attenuates elements of thrombus formation. These data support the cardioprotective value of-3 PUFAs and strongly suggest that they modify elements of platelet function in vivo." @default.
• W2780291211 created "2018-01-05" @default.
• W2780291211 creator A5007426635 @default.
• W2780291211 creator A5028126239 @default.
• W2780291211 creator A5050295448 @default.
• W2780291211 creator A5054918215 @default.
• W2780291211 creator A5056893098 @default.
• W2780291211 creator A5057968833 @default.
• W2780291211 creator A5072502271 @default.
• W2780291211 creator A5073254239 @default.
• W2780291211 creator A5085893830 @default.
• W2780291211 creator A5085977410 @default.
• W2780291211 creator A5087230146 @default.
• W2780291211 creator A5088764798 @default.
• W2780291211 date "2017-12-29" @default.
• W2780291211 modified "2023-10-01" @default.
• W2780291211 title "In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi" @default.
• W2780291211 cites W1845575184 @default.
• W2780291211 cites W1872166996 @default.
• W2780291211 cites W1974866548 @default.
• W2780291211 cites W1984005711 @default.
• W2780291211 cites W1984673037 @default.
• W2780291211 cites W1986451071 @default.
• W2780291211 cites W2014530834 @default.
• W2780291211 cites W2023122926 @default.
• W2780291211 cites W2026310866 @default.
• W2780291211 cites W2026412828 @default.
• W2780291211 cites W2031322663 @default.
• W2780291211 cites W2037984276 @default.
• W2780291211 cites W2040651415 @default.
• W2780291211 cites W2051258508 @default.
• W2780291211 cites W2052608856 @default.
• W2780291211 cites W2064114884 @default.
• W2780291211 cites W2065334259 @default.
• W2780291211 cites W2066812214 @default.
• W2780291211 cites W2068600540 @default.
• W2780291211 cites W2070313752 @default.
• W2780291211 cites W2081938155 @default.
• W2780291211 cites W2082138797 @default.
• W2780291211 cites W2099201390 @default.
• W2780291211 cites W2106363644 @default.
• W2780291211 cites W2109503431 @default.
• W2780291211 cites W2122346622 @default.
• W2780291211 cites W2122656413 @default.
• W2780291211 cites W2124989653 @default.
• W2780291211 cites W2126889659 @default.
• W2780291211 cites W2130621383 @default.
• W2780291211 cites W2130716261 @default.
• W2780291211 cites W2133057213 @default.
• W2780291211 cites W2134094618 @default.
• W2780291211 cites W2137388228 @default.
• W2780291211 cites W2142347023 @default.
• W2780291211 cites W2149981799 @default.
• W2780291211 cites W2152230223 @default.
• W2780291211 cites W2166154572 @default.
• W2780291211 cites W2167075471 @default.
• W2780291211 cites W2169632752 @default.
• W2780291211 cites W2169902118 @default.
• W2780291211 cites W2171245941 @default.
• W2780291211 cites W2176413553 @default.
• W2780291211 cites W2192223169 @default.
• W2780291211 cites W2292962337 @default.
• W2780291211 cites W2310328221 @default.
• W2780291211 cites W2412449504 @default.
• W2780291211 cites W2491676614 @default.
• W2780291211 cites W2597054569 @default.
• W2780291211 cites W2598819486 @default.
• W2780291211 cites W2614282478 @default.
• W2780291211 doi "https://doi.org/10.1080/09537104.2017.1420154" @default.
• W2780291211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6146071" @default.
• W2780291211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29286871" @default.
• W2780291211 hasPublicationYear "2017" @default.
• W2780291211 type Work @default.
• W2780291211 sameAs 2780291211 @default.
• W2780291211 citedByCount "15" @default.
• W2780291211 countsByYear W27802912112018 @default.
• W2780291211 countsByYear W27802912112019 @default.
• W2780291211 countsByYear W27802912112020 @default.
• W2780291211 countsByYear W27802912112021 @default.
• W2780291211 countsByYear W27802912112022 @default.
• W2780291211 countsByYear W27802912112023 @default.
• W2780291211 crossrefType "journal-article" @default.
• W2780291211 hasAuthorship W2780291211A5007426635 @default.
• W2780291211 hasAuthorship W2780291211A5028126239 @default.
• W2780291211 hasAuthorship W2780291211A5050295448 @default.
• W2780291211 hasAuthorship W2780291211A5054918215 @default.
• W2780291211 hasAuthorship W2780291211A5056893098 @default.
• W2780291211 hasAuthorship W2780291211A5057968833 @default.
• W2780291211 hasAuthorship W2780291211A5072502271 @default.
• W2780291211 hasAuthorship W2780291211A5073254239 @default.
• W2780291211 hasAuthorship W2780291211A5085893830 @default.
• W2780291211 hasAuthorship W2780291211A5085977410 @default.
• W2780291211 hasAuthorship W2780291211A5087230146 @default.
• W2780291211 hasAuthorship W2780291211A5088764798 @default.
• W2780291211 hasBestOaLocation W27802912112 @default.
• W2780291211 hasConcept C126322002 @default.
• W2780291211 hasConcept C134018914 @default.
• W2780291211 hasConcept C150903083 @default.

• next