FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780372885> ?p ?o ?g. }

• W2780372885 endingPage "23" @default.
• W2780372885 startingPage "15" @default.
• W2780372885 abstract "The disease model of familial amyloidotic polyneuropathy-7.2-hMet30 mice-manifests amyloid deposition that consists of a human amyloidogenic mutant transthyretin (TTR) (TTR V30M). Our previous study found amyloid deposits in 14 of 27 7.2-hMet30 mice at 21-24 months of age. In addition, non-fibrillar TTR deposits were found in amyloid-negative 7.2hMet30 mice. These results suggested that TTR amyloidogenesis required not only mutant TTR but also an additional factor (or factors) as an etiologic molecule. To determine the differences in serum proteome in amyloid-positive and amyloid-negative mice in the 7.2-hMet30 model, we used proteomic analyses and studied serum samples obtained from these mice. Hemopexin (HPX) and transferrin (Tf) were detected in the serum samples from amyloid-positive mice and were also found in amyloid deposits via immunohistochemistry, but serum samples from amyloid-negative mice did not contain HPX and Tf. These two proteins were also not detected in non-fibrillar TTR deposits. In addition, in silico analyses suggested that HPX and Tf facilitate destabilization of TTR secondary structures and misfolding of TTR. These results suggest that HPX and Tf may be associated with TTR amyloidogenesis after fibrillogenesis in vivo." @default.
• W2780372885 created "2018-01-05" @default.
• W2780372885 creator A5000250306 @default.
• W2780372885 creator A5001371042 @default.
• W2780372885 creator A5004554643 @default.
• W2780372885 creator A5008035231 @default.
• W2780372885 creator A5023755517 @default.
• W2780372885 creator A5027502765 @default.
• W2780372885 creator A5041584550 @default.
• W2780372885 creator A5043778187 @default.
• W2780372885 creator A5046924884 @default.
• W2780372885 creator A5053820982 @default.
• W2780372885 creator A5064949815 @default.
• W2780372885 date "2017-12-29" @default.
• W2780372885 modified "2023-10-16" @default.
• W2780372885 title "Co-precipitation molecules hemopexin and transferrin may be key molecules for fibrillogenesis in TTR V30M amyloidogenesis" @default.
• W2780372885 cites W1031578623 @default.
• W2780372885 cites W1260851397 @default.
• W2780372885 cites W1480950303 @default.
• W2780372885 cites W1794576275 @default.
• W2780372885 cites W1964533214 @default.
• W2780372885 cites W1966529448 @default.
• W2780372885 cites W1966721430 @default.
• W2780372885 cites W1971840315 @default.
• W2780372885 cites W1980125299 @default.
• W2780372885 cites W1988739339 @default.
• W2780372885 cites W1992811485 @default.
• W2780372885 cites W1994157101 @default.
• W2780372885 cites W2008543129 @default.
• W2780372885 cites W2011606718 @default.
• W2780372885 cites W2019261756 @default.
• W2780372885 cites W2051153218 @default.
• W2780372885 cites W2077634973 @default.
• W2780372885 cites W2079513251 @default.
• W2780372885 cites W2126103104 @default.
• W2780372885 cites W2131736388 @default.
• W2780372885 cites W2133712572 @default.
• W2780372885 cites W220969662 @default.
• W2780372885 cites W2338013147 @default.
• W2780372885 cites W240063860 @default.
• W2780372885 cites W2604869186 @default.
• W2780372885 cites W2605535151 @default.
• W2780372885 cites W4240401512 @default.
• W2780372885 cites W4252772420 @default.
• W2780372885 cites W4255594044 @default.
• W2780372885 doi "https://doi.org/10.1007/s11248-017-0054-x" @default.
• W2780372885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5847157" @default.
• W2780372885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29288430" @default.
• W2780372885 hasPublicationYear "2017" @default.
• W2780372885 type Work @default.
• W2780372885 sameAs 2780372885 @default.
• W2780372885 citedByCount "10" @default.
• W2780372885 countsByYear W27803728852018 @default.
• W2780372885 countsByYear W27803728852019 @default.
• W2780372885 countsByYear W27803728852020 @default.
• W2780372885 countsByYear W27803728852021 @default.
• W2780372885 countsByYear W27803728852022 @default.
• W2780372885 crossrefType "journal-article" @default.
• W2780372885 hasAuthorship W2780372885A5000250306 @default.
• W2780372885 hasAuthorship W2780372885A5001371042 @default.
• W2780372885 hasAuthorship W2780372885A5004554643 @default.
• W2780372885 hasAuthorship W2780372885A5008035231 @default.
• W2780372885 hasAuthorship W2780372885A5023755517 @default.
• W2780372885 hasAuthorship W2780372885A5027502765 @default.
• W2780372885 hasAuthorship W2780372885A5041584550 @default.
• W2780372885 hasAuthorship W2780372885A5043778187 @default.
• W2780372885 hasAuthorship W2780372885A5046924884 @default.
• W2780372885 hasAuthorship W2780372885A5053820982 @default.
• W2780372885 hasAuthorship W2780372885A5064949815 @default.
• W2780372885 hasBestOaLocation W27803728851 @default.
• W2780372885 hasConcept C104317684 @default.
• W2780372885 hasConcept C121157162 @default.
• W2780372885 hasConcept C126322002 @default.
• W2780372885 hasConcept C134018914 @default.
• W2780372885 hasConcept C143065580 @default.
• W2780372885 hasConcept C147259501 @default.
• W2780372885 hasConcept C179104552 @default.
• W2780372885 hasConcept C181199279 @default.
• W2780372885 hasConcept C185592680 @default.
• W2780372885 hasConcept C190283241 @default.
• W2780372885 hasConcept C22814914 @default.
• W2780372885 hasConcept C27523624 @default.
• W2780372885 hasConcept C2776217839 @default.
• W2780372885 hasConcept C2776474381 @default.
• W2780372885 hasConcept C2777633098 @default.
• W2780372885 hasConcept C2779134260 @default.
• W2780372885 hasConcept C2779476363 @default.
• W2780372885 hasConcept C2779951007 @default.
• W2780372885 hasConcept C2909607560 @default.
• W2780372885 hasConcept C2994168385 @default.
• W2780372885 hasConcept C3019447875 @default.
• W2780372885 hasConcept C55493867 @default.
• W2780372885 hasConcept C71924100 @default.
• W2780372885 hasConcept C86803240 @default.
• W2780372885 hasConceptScore W2780372885C104317684 @default.
• W2780372885 hasConceptScore W2780372885C121157162 @default.
• W2780372885 hasConceptScore W2780372885C126322002 @default.
• W2780372885 hasConceptScore W2780372885C134018914 @default.

• next