FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780490426> ?p ?o ?g. }

• W2780490426 endingPage "3197" @default.
• W2780490426 startingPage "3190" @default.
• W2780490426 abstract "Huntington disease (HD) is a progressive neurodegenerative disease that initially affects the striatum and leads to changes in behavior and loss of motor coordination. It is caused by an expansion in the polyglutamine repeat at the N terminus of huntingtin (HTT) that leads to aggregation of mutant HTT. The loss of wild-type function, in combination with the toxic gain of function mutation, initiates various cell death pathways. Wild-type and mutant HTT are regulated by different posttranslational modifications that can positively or negatively regulate their function or toxicity. In particular, we have previously shown that caspase cleavage of mutant HTT at amino acid position aspartate 586 (D586) by caspase-6 is critical for the pathogenesis of the disease in an HD mouse model. Herein, we describe the identification of a new caspase cleavage site at position D572 that is mediated by caspase-1. Inhibition of caspase-1 also appeared to decrease proteolysis at D586, likely by blocking the downstream activation of caspase-6 through caspase-1. Inhibition of caspase cleavage at D572 significantly decreased mutant HTT aggregation and significantly increased the turnover of soluble mutant HTT. This suggests that caspase-1 may be a viable target to inhibit caspase cleavage of mutant HTT at both D572 and D586 to promote mutant HTT clearance.—Martin, D. D. O., Schmidt, M. E., Nguyen, Y. T., Lazic, N., Hayden, M. R. Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance. FASEB J. 33, 3190–3197 (2019). www.fasebj.org" @default.
• W2780490426 created "2018-01-05" @default.
• W2780490426 creator A5029968599 @default.
• W2780490426 creator A5047722409 @default.
• W2780490426 creator A5054148151 @default.
• W2780490426 creator A5073026710 @default.
• W2780490426 creator A5079790421 @default.
• W2780490426 date "2018-11-13" @default.
• W2780490426 modified "2023-09-29" @default.
• W2780490426 title "Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance" @default.
• W2780490426 cites W1485896673 @default.
• W2780490426 cites W1531415074 @default.
• W2780490426 cites W1602776657 @default.
• W2780490426 cites W1965301309 @default.
• W2780490426 cites W1972290108 @default.
• W2780490426 cites W1984394485 @default.
• W2780490426 cites W1985734261 @default.
• W2780490426 cites W1988110501 @default.
• W2780490426 cites W2059577521 @default.
• W2780490426 cites W2069686570 @default.
• W2780490426 cites W2084636668 @default.
• W2780490426 cites W2090018999 @default.
• W2780490426 cites W2091888566 @default.
• W2780490426 cites W2094890154 @default.
• W2780490426 cites W2098163379 @default.
• W2780490426 cites W2108466569 @default.
• W2780490426 cites W2114377748 @default.
• W2780490426 cites W2121642311 @default.
• W2780490426 cites W2125054419 @default.
• W2780490426 cites W2128517811 @default.
• W2780490426 cites W2129447571 @default.
• W2780490426 cites W2130012866 @default.
• W2780490426 cites W2135433807 @default.
• W2780490426 cites W2135662322 @default.
• W2780490426 cites W2135732941 @default.
• W2780490426 cites W2136575978 @default.
• W2780490426 cites W2288301981 @default.
• W2780490426 cites W2403972427 @default.
• W2780490426 cites W2794273483 @default.
• W2780490426 cites W2952935356 @default.
• W2780490426 doi "https://doi.org/10.1096/fj.201701510rrr" @default.
• W2780490426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30423259" @default.
• W2780490426 hasPublicationYear "2018" @default.
• W2780490426 type Work @default.
• W2780490426 sameAs 2780490426 @default.
• W2780490426 citedByCount "18" @default.
• W2780490426 countsByYear W27804904262019 @default.
• W2780490426 countsByYear W27804904262020 @default.
• W2780490426 countsByYear W27804904262021 @default.
• W2780490426 countsByYear W27804904262022 @default.
• W2780490426 countsByYear W27804904262023 @default.
• W2780490426 crossrefType "journal-article" @default.
• W2780490426 hasAuthorship W2780490426A5029968599 @default.
• W2780490426 hasAuthorship W2780490426A5047722409 @default.
• W2780490426 hasAuthorship W2780490426A5054148151 @default.
• W2780490426 hasAuthorship W2780490426A5073026710 @default.
• W2780490426 hasAuthorship W2780490426A5079790421 @default.
• W2780490426 hasBestOaLocation W27804904261 @default.
• W2780490426 hasConcept C104317684 @default.
• W2780490426 hasConcept C12519072 @default.
• W2780490426 hasConcept C142724271 @default.
• W2780490426 hasConcept C143065580 @default.
• W2780490426 hasConcept C151730666 @default.
• W2780490426 hasConcept C153911025 @default.
• W2780490426 hasConcept C175156509 @default.
• W2780490426 hasConcept C181199279 @default.
• W2780490426 hasConcept C185592680 @default.
• W2780490426 hasConcept C190283241 @default.
• W2780490426 hasConcept C207583985 @default.
• W2780490426 hasConcept C2776925932 @default.
• W2780490426 hasConcept C2779134260 @default.
• W2780490426 hasConcept C2781307694 @default.
• W2780490426 hasConcept C2781427258 @default.
• W2780490426 hasConcept C2910011555 @default.
• W2780490426 hasConcept C31573885 @default.
• W2780490426 hasConcept C43369102 @default.
• W2780490426 hasConcept C55493867 @default.
• W2780490426 hasConcept C71924100 @default.
• W2780490426 hasConcept C86803240 @default.
• W2780490426 hasConcept C95444343 @default.
• W2780490426 hasConcept C98424977 @default.
• W2780490426 hasConceptScore W2780490426C104317684 @default.
• W2780490426 hasConceptScore W2780490426C12519072 @default.
• W2780490426 hasConceptScore W2780490426C142724271 @default.
• W2780490426 hasConceptScore W2780490426C143065580 @default.
• W2780490426 hasConceptScore W2780490426C151730666 @default.
• W2780490426 hasConceptScore W2780490426C153911025 @default.
• W2780490426 hasConceptScore W2780490426C175156509 @default.
• W2780490426 hasConceptScore W2780490426C181199279 @default.
• W2780490426 hasConceptScore W2780490426C185592680 @default.
• W2780490426 hasConceptScore W2780490426C190283241 @default.
• W2780490426 hasConceptScore W2780490426C207583985 @default.
• W2780490426 hasConceptScore W2780490426C2776925932 @default.
• W2780490426 hasConceptScore W2780490426C2779134260 @default.
• W2780490426 hasConceptScore W2780490426C2781307694 @default.
• W2780490426 hasConceptScore W2780490426C2781427258 @default.
• W2780490426 hasConceptScore W2780490426C2910011555 @default.
• W2780490426 hasConceptScore W2780490426C31573885 @default.

• next