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- W2780498901 abstract "Background: Primary myelofibrosis is a chronic myeloproliferative neoplasm that may cause debilitating symptoms, which can be improved with the use of Ruxolitinib, a Janus kinase 2 inhibitor. However, this agent has significant immunomodulatory effects which may increase the risk for infections.Methods: We searched the literature and our institutional electronic medical record for reported cases of infections in adult patients on ruxolitinib treatment.Results: We found 28 cases in our literature search and 4 cases from our Institution for a total of 32 cases. The most common infection was tuberculosis in 11/32 cases (34%), followed by cryptococcal infection in 3/32 (9%) and hepatitis B virus reactivation in 3/32 (9%).Conclusion: Opportunistic infections associated with ruxolitinib use are increasingly reported in the literature; further studies should investigate the role of systematic screening and prophylaxis against infections in this subset of patients." @default.
- W2780498901 created "2018-01-05" @default.
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- W2780498901 date "2017-12-18" @default.
- W2780498901 modified "2023-09-25" @default.
- W2780498901 title "Infectious complications in patients on treatment with Ruxolitinib: case report and review of the literature" @default.
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- W2780498901 doi "https://doi.org/10.1080/23744235.2017.1390248" @default.
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