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- W2780604865 abstract "ABSTRACTIntroduction: Poly adenosine diphosphate-ribose polymerase (PARP) inhibitors (PARPi) are evolving as one of the most promising therapies in ovarian cancers, especially for patients with a BRCA1/2 or Homologous Recombination Repair (HRR) defect. Rucaparib is one of the three PARPi approved for use in ovarian cancer. Recent research has opened an expanded indication for PARPi beyond germline BRCA1/2 (gBRCA1/2) mutation. This increases the number of patients eligible for PARPi from around 15–20% of high grade serous ovarian cancers (HGSOC) with BRCA1/2 mutations to around 50%.Areas covered: This review focuses on Rucaparib, its pharmacology and salient preclinical and clinical data. The significance of a companion diagnostic test, which helps in selection of patients for Rucaparib, the upcoming trials, future directions and challenges are also discussed.Expert opinion: In germline or somatic BRCA1/2 (g/sBRCA1/2) mutated ovarian cancer patients, Rucaparib is found to have a tolerable side effect profi..." @default.
- W2780604865 created "2018-01-05" @default.
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- W2780604865 date "2017-12-27" @default.
- W2780604865 modified "2023-09-27" @default.
- W2780604865 title "Rucaparib for the treatment of ovarian cancer" @default.
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- W2780604865 doi "https://doi.org/10.1080/21678707.2018.1419129" @default.
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