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- W2780607318 abstract "Aim: To assess the effect of simvastatin on serum levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-6, tumor necrosis factor-α, macrophage colony stimulating factor, C-reactive protein and serum amyloid A in hypercholesterolaemic patients without coronary heart disease. Methods: Sixty consecutive hypercholesterolaemic patients were randomly assigned in a 2:1 process to 40 mg of simvastatin daily (n=40) and to hypolipidaemic only diet (n=20) for 3 months. Blood was taken at baseline and at the end of the study and analysed for lipids and inflammatory markers. Results: From the inflammatory markers only MCP-1 was decreased significantly (217.4±48 versus 177±75 pg/ml, p<0.001) after treatment with simvastatin and this reduction was independent of lipid changes. Conclusion: Simvastatin significantly decreases only MCP-1 levels in hypercholesterolaemic patients suggesting that this molecule is probably a sensitive marker to detect the anti-inflammatory effect of simvastatin in blood. © 2007 Elsevier Ireland Ltd. All rights reserved." @default.
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- W2780607318 date "2008-01-01" @default.
- W2780607318 modified "2023-09-27" @default.
- W2780607318 title "Letter to the Editor Simvastatin exerts its anti-inflammatory effect in hypercholesterolaemic patients by decreasing the serum levels of monocyte chemoattractant protein-1" @default.
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