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• W2780651446 abstract "Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat, mouse, and hamster. Two models that have been particularly well studied are the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR) strains. Acute and repeated AGS, as well as comorbid conditions, displays a close phenotypic overlap in these models. Whether these similarities arise from convergent or divergent structural changes in the brain remains unknown. Here, we examined the brain structure of Sprague Dawley (SD) and Wistar (WIS) rats, and quantified changes in the GEPR-3 and WAR, respectively. Brains from adult, male rats of each strain (n=8-10 per group) were collected, fixed, and embedded in agar and imaged using a 7 tesla Bruker MRI. Post-acquisition analysis included voxel-based morphometry (VBM), diffusion tensor imaging (DTI), and manual volumetric tracing. In the VBM analysis, GEPR-3 displayed volumetric changes in brainstem structures known to be engaged by AGS (e.g., superior and inferior colliculus, periaqueductal grey) and in forebrain structures (e.g., striatum, septum, nucleus accumbens). WAR displayed volumetric changes in superior colliculus, and a broader set of limbic regions (e.g., hippocampus, amygdala/piriform cortex). The only area of significant overlap in the two strains was the midline cerebellum: both GEPR-3 and WAR showed decreased volume compared to their control strains. In the DTI analysis, GEPR-3 displayed decreased fractional anisotropy (FA) in the corpus callosum, posterior commissure and commissure of the inferior colliculus (IC). WAR displayed increased FA only in the commissure of IC. These data provide a biological basis for further comparative and mechanistic studies in the GEPR-3 and WAR models, as well as provide additional insight into commonalities in the pathways underlying AGS susceptibility and behavioral comorbidity." @default.
• W2780651446 created "2018-01-05" @default.
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• W2780651446 date "2018-03-01" @default.
• W2780651446 modified "2023-10-18" @default.
• W2780651446 title "Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR)" @default.
• W2780651446 cites W1504521217 @default.
• W2780651446 cites W1533363848 @default.
• W2780651446 cites W1578980117 @default.
• W2780651446 cites W1834421355 @default.
• W2780651446 cites W1964773597 @default.
• W2780651446 cites W1967701952 @default.
• W2780651446 cites W1970408815 @default.
• W2780651446 cites W1974746937 @default.
• W2780651446 cites W1976167458 @default.
• W2780651446 cites W1980264960 @default.
• W2780651446 cites W1986359797 @default.
• W2780651446 cites W1988193785 @default.
• W2780651446 cites W1988760460 @default.
• W2780651446 cites W1988953707 @default.
• W2780651446 cites W1992325907 @default.
• W2780651446 cites W1994906469 @default.
• W2780651446 cites W1995310991 @default.
• W2780651446 cites W1998289351 @default.
• W2780651446 cites W2011685736 @default.
• W2780651446 cites W2013711455 @default.
• W2780651446 cites W2016136905 @default.
• W2780651446 cites W2017140635 @default.
• W2780651446 cites W2017860427 @default.
• W2780651446 cites W2018084704 @default.
• W2780651446 cites W2020227191 @default.
• W2780651446 cites W2020869644 @default.
• W2780651446 cites W2023642970 @default.
• W2780651446 cites W2023669148 @default.
• W2780651446 cites W2027605642 @default.
• W2780651446 cites W2027740519 @default.
• W2780651446 cites W2028438346 @default.
• W2780651446 cites W2034270682 @default.
• W2780651446 cites W2035595995 @default.
• W2780651446 cites W2035788765 @default.
• W2780651446 cites W2036046547 @default.
• W2780651446 cites W2038697251 @default.
• W2780651446 cites W2038707756 @default.
• W2780651446 cites W2039121267 @default.
• W2780651446 cites W2041010963 @default.
• W2780651446 cites W2048359909 @default.
• W2780651446 cites W2051141570 @default.
• W2780651446 cites W2052988498 @default.
• W2780651446 cites W2054568773 @default.
• W2780651446 cites W2056775516 @default.
• W2780651446 cites W2057150750 @default.
• W2780651446 cites W2057184609 @default.
• W2780651446 cites W2058798356 @default.
• W2780651446 cites W2061243259 @default.
• W2780651446 cites W2065523952 @default.
• W2780651446 cites W2067840049 @default.
• W2780651446 cites W2075961353 @default.
• W2780651446 cites W2076927394 @default.
• W2780651446 cites W2080961275 @default.
• W2780651446 cites W2081067812 @default.
• W2780651446 cites W2082225767 @default.
• W2780651446 cites W2083794141 @default.
• W2780651446 cites W2086949990 @default.
• W2780651446 cites W2090031248 @default.
• W2780651446 cites W2093071169 @default.
• W2780651446 cites W2113981430 @default.
• W2780651446 cites W2122391500 @default.
• W2780651446 cites W2123753329 @default.
• W2780651446 cites W2124338949 @default.
• W2780651446 cites W2127319153 @default.
• W2780651446 cites W2129728343 @default.
• W2780651446 cites W2155298532 @default.
• W2780651446 cites W2170679961 @default.
• W2780651446 cites W2202510332 @default.
• W2780651446 cites W2313362397 @default.
• W2780651446 cites W2314516992 @default.
• W2780651446 cites W2405599751 @default.
• W2780651446 cites W2413673292 @default.
• W2780651446 cites W2517827787 @default.
• W2780651446 cites W2519602369 @default.
• W2780651446 cites W2613672840 @default.
• W2780651446 cites W2648952709 @default.
• W2780651446 cites W3147688718 @default.
• W2780651446 cites W4230920194 @default.
• W2780651446 cites W950038772 @default.
• W2780651446 doi "https://doi.org/10.1016/j.nbd.2017.12.014" @default.
• W2780651446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5803386" @default.
• W2780651446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29274430" @default.
• W2780651446 hasPublicationYear "2018" @default.

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