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• W2780676783 abstract "Humans exposed to asbestos and/or asbestiform fibers are at high risk of developing many lung diseases including asbestosis, lung cancer, and malignant mesothelioma. However, the disease-causing potential and specific metabolic mechanisms and pathways associated with various asbestos/asbestiform fiber exposures triggering different carcinogenic and non-carcinogenic outcomes are still largely unknown. The aim of this this study was to investigate gene expression profiles and inflammatory responses to different asbestos/asbestiform fibers at the acute/sub-acute phase that may be related to delayed pathological outcomes observed at later time points. Mice were exposed to asbestos (crocidolite, tremolite asbestos), asbestiform fibers (erionite), and a low pathogenicity mineral fiber (wollastonite) using oropharyngeal aspiration. Similarities in inflammatory and tissue damage responses, albeit with quantitative differences, were observed at day 1 and 7 post treatment. Exposure to different fibers induced significant changes in regulation and release of a number of inflammatory cytokines/chemokines. Comparative analysis of changes in gene regulation in the lung on day 7 post exposure were interpretable in the context of differential biological responses that were consistent with histopathological findings at days 7 and 56 post treatment. Our results noted differences in the magnitudes of pulmonary responses and gene regulation consistent with pathological alterations induced by exposures to four asbestos/asbestiform fibers examined. Further comparative mechanistic studies linking early responses with the long-term endpoints may be instrumental to understanding triggering mechanisms underlying pulmonary carcinogenesis, that is lung cancer versus mesothelioma." @default.
• W2780676783 created "2018-01-05" @default.
• W2780676783 creator A5030348396 @default.
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• W2780676783 creator A5069406228 @default.
• W2780676783 date "2017-12-26" @default.
• W2780676783 modified "2023-10-14" @default.
• W2780676783 title "Characterization of pulmonary responses in mice to asbestos/asbestiform fibers using gene expression profiles" @default.
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• W2780676783 doi "https://doi.org/10.1080/15287394.2017.1408201" @default.
• W2780676783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29279043" @default.
• W2780676783 hasPublicationYear "2017" @default.
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