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- W2780687143 abstract "Mediastinal nonseminomatous germ cell tumor (NSGCT) is an uncommon entity. Metastatic hepatic sarcomatous transformation is rare.We report a 24-year-old man with no previous related medical history presented with chest pain and left arm numbness.The x-ray showed an anterior mediastinal mass. The chest computed tomography (CT) confirmed the presence of a mildly enhancing mass in the same location, without invasion of any vascular structure. A CT-guided biopsy was performed, revealing a primary mediastinal nonseminomatous germ cell tumor (NSGCT), yolk sac histology, with areas of somatic transformation to malignant nerve sheath tumor. After surgery patient was followed-up with imaging. Two years later a CT scan showed a new hepatic hyper vascular lesion, confirmed by a subsequent magnetic resonance imaging (MRI) and positron emission tomography (PET) scan. A CT-guided biopsy revealed a hepatic metastatic transformation to angiosarcoma of the primitive NSGCT.The patient went on to received palliative chemotherapy.The patient is being followed-up regularly at the outpatient department.Because of the potential of metastatic sarcoma arising from germ cell tumors, these patients should undergo periodical follow-up, with periodical scans. PETCT scan might have a role in the follow-up of these patients." @default.
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- W2780687143 date "2017-12-01" @default.
- W2780687143 modified "2023-09-26" @default.
- W2780687143 title "Hepatic angiosarcomatous transformation of a mediastinal germinal cell tumor" @default.
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- W2780687143 doi "https://doi.org/10.1097/md.0000000000009152" @default.
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