Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780704144> ?p ?o ?g. }
- W2780704144 endingPage "381" @default.
- W2780704144 startingPage "373" @default.
- W2780704144 abstract "OmpAAb is a conserved, abundantly expressed outer membrane porin in Acinetobacter baumannii whose presumed role in antibiotic permeation has not been clearly demonstrated. In this report, we use a titratable heterologous expression system to express OmpAAb in isolation and demonstrate selective passage of small molecule antibiotics through OmpAAb. ETX2514, a recently discovered broad-spectrum β-lactamase inhibitor, in combination with sulbactam, is currently in clinical testing for the treatment of drug-resistant A. baumannii infections. We demonstrate that ETX2514 permeates OmpAAb and potentiates the activity of sulbactam in an OmpAAb-dependent manner. In addition, we show that small modifications in the structure of ETX2514 differentially affect its passage through OmpAAb, revealing unique structure-porin-permeation relationships. Finally, we confirm the contribution of OmpAAb to bacterial fitness using a murine thigh model of A. baumannii infection. These results, combined with the high sequence homolo..." @default.
- W2780704144 created "2018-01-05" @default.
- W2780704144 creator A5006271408 @default.
- W2780704144 creator A5044352209 @default.
- W2780704144 creator A5052120675 @default.
- W2780704144 creator A5083446220 @default.
- W2780704144 creator A5089989887 @default.
- W2780704144 date "2017-12-20" @default.
- W2780704144 modified "2023-10-17" @default.
- W2780704144 title "<i>Acinetobacter baumannii</i> OmpA Is a Selective Antibiotic Permeant Porin" @default.
- W2780704144 cites W1920890130 @default.
- W2780704144 cites W1981267913 @default.
- W2780704144 cites W1984486223 @default.
- W2780704144 cites W1991633654 @default.
- W2780704144 cites W1996764065 @default.
- W2780704144 cites W2012186239 @default.
- W2780704144 cites W2014405748 @default.
- W2780704144 cites W2021938691 @default.
- W2780704144 cites W2024103813 @default.
- W2780704144 cites W2035174398 @default.
- W2780704144 cites W2056957102 @default.
- W2780704144 cites W2061379882 @default.
- W2780704144 cites W2061841875 @default.
- W2780704144 cites W2069449656 @default.
- W2780704144 cites W2073822812 @default.
- W2780704144 cites W2075287054 @default.
- W2780704144 cites W2080274710 @default.
- W2780704144 cites W2086460365 @default.
- W2780704144 cites W2104176117 @default.
- W2780704144 cites W2104582297 @default.
- W2780704144 cites W2111346637 @default.
- W2780704144 cites W2113643142 @default.
- W2780704144 cites W2120061656 @default.
- W2780704144 cites W2125832211 @default.
- W2780704144 cites W2126480284 @default.
- W2780704144 cites W2126750975 @default.
- W2780704144 cites W2127028391 @default.
- W2780704144 cites W2127999800 @default.
- W2780704144 cites W2128433990 @default.
- W2780704144 cites W2132620230 @default.
- W2780704144 cites W2134919621 @default.
- W2780704144 cites W2135039696 @default.
- W2780704144 cites W2135113667 @default.
- W2780704144 cites W2139516496 @default.
- W2780704144 cites W2139791291 @default.
- W2780704144 cites W2141930177 @default.
- W2780704144 cites W2158366997 @default.
- W2780704144 cites W2159435953 @default.
- W2780704144 cites W2159469354 @default.
- W2780704144 cites W2159584001 @default.
- W2780704144 cites W2159588618 @default.
- W2780704144 cites W2160185557 @default.
- W2780704144 cites W2160956441 @default.
- W2780704144 cites W2161201184 @default.
- W2780704144 cites W2291763810 @default.
- W2780704144 cites W2291994222 @default.
- W2780704144 cites W2296386957 @default.
- W2780704144 cites W2313186831 @default.
- W2780704144 cites W2340886826 @default.
- W2780704144 cites W2341978686 @default.
- W2780704144 cites W2551597808 @default.
- W2780704144 cites W2581955658 @default.
- W2780704144 cites W2585296307 @default.
- W2780704144 cites W2594303706 @default.
- W2780704144 cites W2616780952 @default.
- W2780704144 cites W2620487012 @default.
- W2780704144 cites W2728041751 @default.
- W2780704144 cites W2737397887 @default.
- W2780704144 cites W2763322245 @default.
- W2780704144 cites W2770039722 @default.
- W2780704144 doi "https://doi.org/10.1021/acsinfecdis.7b00168" @default.
- W2780704144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29260856" @default.
- W2780704144 hasPublicationYear "2017" @default.
- W2780704144 type Work @default.
- W2780704144 sameAs 2780704144 @default.
- W2780704144 citedByCount "56" @default.
- W2780704144 countsByYear W27807041442018 @default.
- W2780704144 countsByYear W27807041442019 @default.
- W2780704144 countsByYear W27807041442020 @default.
- W2780704144 countsByYear W27807041442021 @default.
- W2780704144 countsByYear W27807041442022 @default.
- W2780704144 countsByYear W27807041442023 @default.
- W2780704144 crossrefType "journal-article" @default.
- W2780704144 hasAuthorship W2780704144A5006271408 @default.
- W2780704144 hasAuthorship W2780704144A5044352209 @default.
- W2780704144 hasAuthorship W2780704144A5052120675 @default.
- W2780704144 hasAuthorship W2780704144A5083446220 @default.
- W2780704144 hasAuthorship W2780704144A5089989887 @default.
- W2780704144 hasConcept C104317684 @default.
- W2780704144 hasConcept C146587185 @default.
- W2780704144 hasConcept C2776315533 @default.
- W2780704144 hasConcept C2777317804 @default.
- W2780704144 hasConcept C2777637488 @default.
- W2780704144 hasConcept C501593827 @default.
- W2780704144 hasConcept C523546767 @default.
- W2780704144 hasConcept C54355233 @default.
- W2780704144 hasConcept C547475151 @default.
- W2780704144 hasConcept C86803240 @default.