FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780736628> ?p ?o ?g. }

• W2780736628 abstract "Background: We have previously reported altered gene expression in adults with asthma compared to healthy controls from the U-BIOPRED study (Bigler, 2016). Altered transcripts may define dysregulated biological pathways and identify novel therapeutic targets. We hypothesised that similar dysregulation would be seen in children with asthma. Aim: To compare blood transcriptomic profiles of children and adults with asthma. Methods: Affymetrix blood transcriptomic profiles of severe asthmatic adult non-smokers, n=152, were compared to mild moderate asthmatics, n=50 (Shaw, 2015; Fleming, 2015). Profiles of school-aged children with severe asthma, n=75, were compared to mild moderate asthmatics, n=37, and in the preschool age group severe wheeze, n=62, was compared to mild moderate wheeze, n=42. Differentially expressed genes (DEG) were identified as probe sets with maximum median group intensity >log2 5, with a significant (raw P≤0.01) change ≥ 20%. Overlapping genes were determined and pathway analysis performed. Results: We found 1887 DEG comparing severe and mild moderate asthmatic adults. Only 28 DEG were found between the severe wheeze and mild pre-school age children, with a larger signature (569 DEG) in the school aged children. 480 genes were specific to school-aged children and 1801 specific to adults, with 89 DEG in common between the adults and school-aged children. Conclusions: Preschool age children were poorly defined in terms of blood transcriptomics by the clinical definitions used. While the school-aged children showed some DEG overlap with the adults, they were distinct in many DEG and pathways indicating that childhood and adult asthma may be mechanistically different." @default.
• W2780736628 created "2018-01-05" @default.
• W2780736628 creator A5005675278 @default.
• W2780736628 creator A5010037722 @default.
• W2780736628 creator A5012287816 @default.
• W2780736628 creator A5013745056 @default.
• W2780736628 creator A5014990556 @default.
• W2780736628 creator A5020332377 @default.
• W2780736628 creator A5026235503 @default.
• W2780736628 creator A5036414874 @default.
• W2780736628 creator A5043576559 @default.
• W2780736628 creator A5044179945 @default.
• W2780736628 creator A5044613710 @default.
• W2780736628 creator A5046225789 @default.
• W2780736628 creator A5047985554 @default.
• W2780736628 creator A5053929091 @default.
• W2780736628 creator A5055008823 @default.
• W2780736628 creator A5056446970 @default.
• W2780736628 creator A5058751400 @default.
• W2780736628 creator A5060442315 @default.
• W2780736628 creator A5063238032 @default.
• W2780736628 creator A5063471621 @default.
• W2780736628 creator A5063587197 @default.
• W2780736628 creator A5065281895 @default.
• W2780736628 creator A5066999105 @default.
• W2780736628 creator A5068864839 @default.
• W2780736628 creator A5071804475 @default.
• W2780736628 creator A5074232553 @default.
• W2780736628 creator A5081302632 @default.
• W2780736628 creator A5084067815 @default.
• W2780736628 creator A5084604448 @default.
• W2780736628 creator A5085877701 @default.
• W2780736628 creator A5087202654 @default.
• W2780736628 date "2017-09-01" @default.
• W2780736628 modified "2023-10-02" @default.
• W2780736628 title "Late Breaking Abstract - Comparison of the blood transcriptomic profiles of adults and children from the U-BIOPRED asthma study" @default.
• W2780736628 doi "https://doi.org/10.1183/1393003.congress-2017.oa3442" @default.
• W2780736628 hasPublicationYear "2017" @default.
• W2780736628 type Work @default.
• W2780736628 sameAs 2780736628 @default.
• W2780736628 citedByCount "0" @default.
• W2780736628 crossrefType "proceedings-article" @default.
• W2780736628 hasAuthorship W2780736628A5005675278 @default.
• W2780736628 hasAuthorship W2780736628A5010037722 @default.
• W2780736628 hasAuthorship W2780736628A5012287816 @default.
• W2780736628 hasAuthorship W2780736628A5013745056 @default.
• W2780736628 hasAuthorship W2780736628A5014990556 @default.
• W2780736628 hasAuthorship W2780736628A5020332377 @default.
• W2780736628 hasAuthorship W2780736628A5026235503 @default.
• W2780736628 hasAuthorship W2780736628A5036414874 @default.
• W2780736628 hasAuthorship W2780736628A5043576559 @default.
• W2780736628 hasAuthorship W2780736628A5044179945 @default.
• W2780736628 hasAuthorship W2780736628A5044613710 @default.
• W2780736628 hasAuthorship W2780736628A5046225789 @default.
• W2780736628 hasAuthorship W2780736628A5047985554 @default.
• W2780736628 hasAuthorship W2780736628A5053929091 @default.
• W2780736628 hasAuthorship W2780736628A5055008823 @default.
• W2780736628 hasAuthorship W2780736628A5056446970 @default.
• W2780736628 hasAuthorship W2780736628A5058751400 @default.
• W2780736628 hasAuthorship W2780736628A5060442315 @default.
• W2780736628 hasAuthorship W2780736628A5063238032 @default.
• W2780736628 hasAuthorship W2780736628A5063471621 @default.
• W2780736628 hasAuthorship W2780736628A5063587197 @default.
• W2780736628 hasAuthorship W2780736628A5065281895 @default.
• W2780736628 hasAuthorship W2780736628A5066999105 @default.
• W2780736628 hasAuthorship W2780736628A5068864839 @default.
• W2780736628 hasAuthorship W2780736628A5071804475 @default.
• W2780736628 hasAuthorship W2780736628A5074232553 @default.
• W2780736628 hasAuthorship W2780736628A5081302632 @default.
• W2780736628 hasAuthorship W2780736628A5084067815 @default.
• W2780736628 hasAuthorship W2780736628A5084604448 @default.
• W2780736628 hasAuthorship W2780736628A5085877701 @default.
• W2780736628 hasAuthorship W2780736628A5087202654 @default.
• W2780736628 hasConcept C104317684 @default.
• W2780736628 hasConcept C126322002 @default.
• W2780736628 hasConcept C150194340 @default.
• W2780736628 hasConcept C162317418 @default.
• W2780736628 hasConcept C187212893 @default.
• W2780736628 hasConcept C203014093 @default.
• W2780736628 hasConcept C2776042228 @default.
• W2780736628 hasConcept C2778338976 @default.
• W2780736628 hasConcept C54355233 @default.
• W2780736628 hasConcept C71924100 @default.
• W2780736628 hasConcept C86803240 @default.
• W2780736628 hasConceptScore W2780736628C104317684 @default.
• W2780736628 hasConceptScore W2780736628C126322002 @default.
• W2780736628 hasConceptScore W2780736628C150194340 @default.
• W2780736628 hasConceptScore W2780736628C162317418 @default.
• W2780736628 hasConceptScore W2780736628C187212893 @default.
• W2780736628 hasConceptScore W2780736628C203014093 @default.
• W2780736628 hasConceptScore W2780736628C2776042228 @default.
• W2780736628 hasConceptScore W2780736628C2778338976 @default.
• W2780736628 hasConceptScore W2780736628C54355233 @default.
• W2780736628 hasConceptScore W2780736628C71924100 @default.
• W2780736628 hasConceptScore W2780736628C86803240 @default.
• W2780736628 hasLocation W27807366281 @default.
• W2780736628 hasOpenAccess W2780736628 @default.
• W2780736628 hasPrimaryLocation W27807366281 @default.
• W2780736628 hasRelatedWork W1830805245 @default.
• W2780736628 hasRelatedWork W1844796707 @default.

• next