FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2780775558> ?p ?o ?g. }

• W2780775558 endingPage "204" @default.
• W2780775558 startingPage "197" @default.
• W2780775558 abstract "pH-Sensitive fusogenic polymer-modified (pH-sensitive) liposomes co-loaded with tumor model antigen, ovalbumin (OVA), and adjuvant, α-galactosylceramide (α-GalCer) were fabricated and administered subcutaneously into mice. The ability of pH-sensitive liposomes containing OVA and α-GalCer to stimulate cellular and humoral immune responses in vivo was compared with OVA-encapsulating pH-sensitive liposomes as well as with OVA alone. After immunization, significant OVA-specific antibodies were detected in the serum. When sera were analyzed for isotype distribution, antigen-specific IgG1 antibody responses were noted in mice immunized with OVA alone, whereas immunization with OVA-containing pH-sensitive liposomes and with pH-sensitive liposomes containing OVA and α-GalCer resulted in the induction of OVA-specific IgG1 and IgG2b antibody responses. Moreover, more substantial production of IFN-γ and IL-4 was demonstrated in spleen cells from mice immunized with pH-sensitive liposomes having OVA and α-GalCer than OVA-containing pH-sensitive liposomes in vitro. Spleen cells from the immunized mice showed strong cytotoxic activity against E.G7-OVA tumor cells. In addition, prophylactic vaccination efficacy against tumor formation was evaluated. In all mice immunized with pH-sensitive liposomes having OVA and α-GalCer, immunization provided substantial protection from tumor formation. The therapeutic efficacy of pH-sensitive liposomes containing OVA and α-GalCer against already established E.G7-OVA tumors was also investigated. Tumor growth was reduced significantly in all mice treated with pH-sensitive liposomes having OVA and α-GalCer. The provided evidence on the advantage of antigen and α-GalCer co-encapsulation into pH-sensitive liposomes should be considered in the design of future cancer vaccines for prophylactic and therapeutic purposes." @default.
• W2780775558 created "2018-01-05" @default.
• W2780775558 creator A5009690302 @default.
• W2780775558 creator A5013248485 @default.
• W2780775558 creator A5018664511 @default.
• W2780775558 creator A5072002824 @default.
• W2780775558 date "2018-01-01" @default.
• W2780775558 modified "2023-09-24" @default.
• W2780775558 title "Evaluation of pH-sensitive fusogenic polymer-modified liposomes co-loaded with antigen and α-galactosylceramide as an anti-tumor vaccine" @default.
• W2780775558 cites W1454490287 @default.
• W2780775558 cites W1616445679 @default.
• W2780775558 cites W1747545477 @default.
• W2780775558 cites W1766867548 @default.
• W2780775558 cites W1832720893 @default.
• W2780775558 cites W1868738850 @default.
• W2780775558 cites W1888349295 @default.
• W2780775558 cites W1926524992 @default.
• W2780775558 cites W1963895695 @default.
• W2780775558 cites W1984699683 @default.
• W2780775558 cites W1990846517 @default.
• W2780775558 cites W2009634517 @default.
• W2780775558 cites W2032986193 @default.
• W2780775558 cites W2044835625 @default.
• W2780775558 cites W2048724356 @default.
• W2780775558 cites W2061467668 @default.
• W2780775558 cites W2068844427 @default.
• W2780775558 cites W2069556438 @default.
• W2780775558 cites W2082058005 @default.
• W2780775558 cites W2083549635 @default.
• W2780775558 cites W2091987784 @default.
• W2780775558 cites W2100540383 @default.
• W2780775558 cites W2105459360 @default.
• W2780775558 cites W2106067112 @default.
• W2780775558 cites W2118403212 @default.
• W2780775558 cites W2118599195 @default.
• W2780775558 cites W2134106722 @default.
• W2780775558 cites W2138651252 @default.
• W2780775558 cites W2141795482 @default.
• W2780775558 cites W2149079955 @default.
• W2780775558 cites W2169320123 @default.
• W2780775558 doi "https://doi.org/10.1292/jvms.17-0491" @default.
• W2780775558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5836753" @default.
• W2780775558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29311431" @default.
• W2780775558 hasPublicationYear "2018" @default.
• W2780775558 type Work @default.
• W2780775558 sameAs 2780775558 @default.
• W2780775558 citedByCount "17" @default.
• W2780775558 countsByYear W27807755582019 @default.
• W2780775558 countsByYear W27807755582020 @default.
• W2780775558 countsByYear W27807755582021 @default.
• W2780775558 countsByYear W27807755582022 @default.
• W2780775558 countsByYear W27807755582023 @default.
• W2780775558 crossrefType "journal-article" @default.
• W2780775558 hasAuthorship W2780775558A5009690302 @default.
• W2780775558 hasAuthorship W2780775558A5013248485 @default.
• W2780775558 hasAuthorship W2780775558A5018664511 @default.
• W2780775558 hasAuthorship W2780775558A5072002824 @default.
• W2780775558 hasBestOaLocation W27807755581 @default.
• W2780775558 hasConcept C147483822 @default.
• W2780775558 hasConcept C150903083 @default.
• W2780775558 hasConcept C153911025 @default.
• W2780775558 hasConcept C159654299 @default.
• W2780775558 hasConcept C185154212 @default.
• W2780775558 hasConcept C185592680 @default.
• W2780775558 hasConcept C203014093 @default.
• W2780775558 hasConcept C207001950 @default.
• W2780775558 hasConcept C2776946954 @default.
• W2780775558 hasConcept C2777863537 @default.
• W2780775558 hasConcept C2780801004 @default.
• W2780775558 hasConcept C2780931953 @default.
• W2780775558 hasConcept C55493867 @default.
• W2780775558 hasConcept C86803240 @default.
• W2780775558 hasConcept C8891405 @default.
• W2780775558 hasConceptScore W2780775558C147483822 @default.
• W2780775558 hasConceptScore W2780775558C150903083 @default.
• W2780775558 hasConceptScore W2780775558C153911025 @default.
• W2780775558 hasConceptScore W2780775558C159654299 @default.
• W2780775558 hasConceptScore W2780775558C185154212 @default.
• W2780775558 hasConceptScore W2780775558C185592680 @default.
• W2780775558 hasConceptScore W2780775558C203014093 @default.
• W2780775558 hasConceptScore W2780775558C207001950 @default.
• W2780775558 hasConceptScore W2780775558C2776946954 @default.
• W2780775558 hasConceptScore W2780775558C2777863537 @default.
• W2780775558 hasConceptScore W2780775558C2780801004 @default.
• W2780775558 hasConceptScore W2780775558C2780931953 @default.
• W2780775558 hasConceptScore W2780775558C55493867 @default.
• W2780775558 hasConceptScore W2780775558C86803240 @default.
• W2780775558 hasConceptScore W2780775558C8891405 @default.
• W2780775558 hasIssue "2" @default.
• W2780775558 hasLocation W27807755581 @default.
• W2780775558 hasLocation W27807755582 @default.
• W2780775558 hasLocation W27807755583 @default.
• W2780775558 hasLocation W27807755584 @default.
• W2780775558 hasOpenAccess W2780775558 @default.
• W2780775558 hasPrimaryLocation W27807755581 @default.
• W2780775558 hasRelatedWork W2033998433 @default.
• W2780775558 hasRelatedWork W2034807705 @default.
• W2780775558 hasRelatedWork W2079721126 @default.

• next