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- W2780811298 abstract "Due to its predictable self-assembly and structural stability, structural DNA nanotechnology is considered one of the main interdisciplinary subjects encompassing conventional nanotechnology and biotechnology. Here we have fabricated the mucin aptamer (MUC1)-conjugated DNA nano-ring intercalated with doxorubicin (DNRA-DOX) as potential therapeutics for breast cancer. DNRA-DOX exhibited significantly higher cytotoxicity to the MCF-7 breast cancer cells than the controls, including DOX alone and the aptamer deficient DNA nano-ring (DNR) with doxorubicin. Interactions between DOX and DNRA were studied using spectrophotometric measurements. Dose-dependent cytotoxicity was performed to prove that both DNR and DNRA were non-toxic to the cells. The drug release profile showed a controlled release of DOX at normal physiological pH 7.4, with approximately 61% released, but when exposed to lysosomal of pH 5.5, the corresponding 95% was released within 48 h. Owing to the presence of the aptamer, DNRA-DOX was effectively taken up by the cancer cells, as confirmed by confocal microscopy, implying that it has potential for use in targeted drug delivery." @default.
- W2780811298 created "2018-01-05" @default.
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- W2780811298 date "2018-01-25" @default.
- W2780811298 modified "2023-10-03" @default.
- W2780811298 title "Aptamer-conjugated DNA nano-ring as the carrier of drug molecules" @default.
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- W2780811298 doi "https://doi.org/10.1088/1361-6528/aaa3cb" @default.
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- W2780811298 hasPublicationYear "2018" @default.
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