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• W2780926841 abstract "Understanding the consequences of thermal and chemical variations in aquatic habitats is of importance in a scenario of global change. In ecology, the sex ratio is a major population demographic parameter. So far, research that measured environmental perturbations on fish sex ratios has usually involved a few model species with a strong genetic basis of sex determination, and focused on the study of juvenile or adult gonads. However, the underlying mechanisms at the time of gender commitment are poorly understood. In an effort to elucidate the mechanisms driving sex differentiation, here we used the European sea bass, a fish species where genetics and environment (temperature) contribute equally to sex determination. Here, we analyzed the transcriptome of developing gonads experiencing either testis or ovarian differentiation as a result of thermal and/or exogenous estrogen influences. These external insults elicited different responses. Thus, while elevated temperature masculinized genetic females, estrogen exposure was able to override thermal effects and resulted in an all-female population. A total of 383 genes were differentially expressed, with an overall downregulation in the expression of genes involved in both in testicular and ovarian differentiation when fish were exposed to Estradiol-17ß through a shutdown of the first steps of steroidogenesis. However, once the female phenotype was imposed, gonads could continue their normal development, even taking into account that some of the resulting females were fish that otherwise would have developed as males. The data on the underlying mechanisms operating at the molecular level presented here contribute to a better understanding of the sex ratio response of fish species subjected to a combination of two of the most common environmental perturbations and can have implications in future conservational policies." @default.
• W2780926841 created "2018-01-05" @default.
• W2780926841 creator A5005189798 @default.
• W2780926841 creator A5090634777 @default.
• W2780926841 date "2017-12-01" @default.
• W2780926841 modified "2023-10-16" @default.
• W2780926841 title "Estrogen exposure overrides the masculinizing effect of elevated temperature by a downregulation of the key genes implicated in sexual differentiation in a fish with mixed genetic and environmental sex determination" @default.
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• W2780926841 doi "https://doi.org/10.1186/s12864-017-4345-7" @default.
• W2780926841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5735924" @default.
• W2780926841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29254503" @default.
• W2780926841 hasPublicationYear "2017" @default.
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