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- W2780987007 abstract "The role of DNA methylation for lung function, needs exploring, as it may help identify genes and pathways of importance for lung function. The aim of this study was to explore the association between blood DNA methylation and lung function in monozygotic (MZ) twins. A sample of 169 middle-aged MZ twin-pairs was included in an epigenome-wide association study. They were collected from the Danish Twin Register and examined at baseline (1998-1999) and follow-up (2008-2011). Using the twin-design, we correlated intra-pair differences in cross-sectional and longitudinal lung function with intra-pair blood DNA methylation differences at follow-up by linear regression analyses adjusted for sex, age, BMI, smoking, and blood-cell-composition. We identified several differentially methylated CpG sites associated with Forced Expiratory Volume the 1<sup>st</sup> second (FEV<sub>1</sub>) and Forced Vital Capacity (FVC). Three probes identified for FVC level were located in <i>GLIPR1L2</i> (p-value=7.14x10<sup>−8</sup>), a gene involved in innate immunity, and tumour-suppressor/pro-oncogenic mechanisms. Change in FEV<sub>1</sub> during the follow-up period was associated with methylation level in <i>TRIM27</i> (p-value=1.55x10<sup>‑6</sup>), a negative regulator of CD4-T-cells also involved in cancer development. Several enriched pathways were identified; for FEV<sub>1</sub> e.g. “TGFBR” (Benjamini-Hochberg<sub>adj</sub> p-value=0.045), the receptor for TGFβ, a growth-factor involved in normal lung tissue repair through pro-fibrotic effects. Our findings suggest that blood DNA methylation signatures are associated with lung function, identifying immunological- and cancer-related genes, as well as TGF-β-receptor related genes to be possibly involved in the level and change in lung function." @default.
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- W2780987007 date "2017-09-01" @default.
- W2780987007 modified "2023-10-10" @default.
- W2780987007 title "Lung function discordance in monozygotic twins and associated differences in blood DNA methylation" @default.
- W2780987007 doi "https://doi.org/10.1183/1393003.congress-2017.oa2943" @default.
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