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• W2781054453 abstract "Na+/Ca2+ exchangers (NCXs) are expressed primarily in the plasma membrane of most cell types, where they mediate electrogenic exchange of one Ca2+ for three Na+ ions, depending on Ca2+ and Na+ electrochemical gradients across the membrane. Three mammalian NCX isoforms (NCX1, NCX2, and NCX3) are each encoded by a distinct gene. Here, we report that NCX2 and NCX3 protein and mRNA levels are relatively reduced in hippocampal CA1 of APP23 and APP-KI mice. Likewise, NCX2+/- or NCX3+/- mice exhibited impaired hippocampal LTP and memory-related behaviors. Moreover, relative to controls, calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation significantly decreased in NCX2+/- mouse hippocampus but increased in hippocampus of NCX3+/- mice. NCX2 or NCX3 heterozygotes displayed impaired maintenance of hippocampal LTP, a phenotype that in NCX2+/- mice was correlated with elevated calcineurin activity and rescued by treatment with the calcineurin (CaN) inhibitor FK506. Likewise, FK506 treatment significantly restored impaired hippocampal LTP in APP-KI mice. Moreover, Ca2+ clearance after depolarization following high frequency stimulation was slightly delayed in hippocampal CA1 regions of NCX2+/- mice. Electron microscopy revealed relatively decreased synaptic density in CA1 of NCX2+/- mice, while the number of spines with perforated synapses in CA1 significantly increased in NCX3+/- mice. We conclude that memory impairment seen in NCX2+/- and NCX3+/- mice reflect dysregulated hippocampal CaMKII activity, which alters dendritic spine morphology, findings with implications for memory deficits seen in Alzheimer's disease model mice." @default.
• W2781054453 created "2018-01-05" @default.
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• W2781054453 date "2018-03-01" @default.
• W2781054453 modified "2023-10-17" @default.
• W2781054453 title "Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice" @default.
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• W2781054453 cites W1560716065 @default.
• W2781054453 cites W1585660326 @default.
• W2781054453 cites W1964784938 @default.
• W2781054453 cites W1969414063 @default.
• W2781054453 cites W1977916691 @default.
• W2781054453 cites W1979318504 @default.
• W2781054453 cites W1979663362 @default.
• W2781054453 cites W1981250359 @default.
• W2781054453 cites W1983894269 @default.
• W2781054453 cites W1984882298 @default.
• W2781054453 cites W1986782732 @default.
• W2781054453 cites W1987714678 @default.
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• W2781054453 cites W1993465897 @default.
• W2781054453 cites W1995344309 @default.
• W2781054453 cites W1995854149 @default.
• W2781054453 cites W1996771733 @default.
• W2781054453 cites W1999903260 @default.
• W2781054453 cites W2010605892 @default.
• W2781054453 cites W2011280723 @default.
• W2781054453 cites W2021450321 @default.
• W2781054453 cites W2028068971 @default.
• W2781054453 cites W2033248674 @default.
• W2781054453 cites W2033329010 @default.
• W2781054453 cites W2035189284 @default.
• W2781054453 cites W2035835440 @default.
• W2781054453 cites W2035880579 @default.
• W2781054453 cites W2049775854 @default.
• W2781054453 cites W2052863274 @default.
• W2781054453 cites W2056607057 @default.
• W2781054453 cites W2059201211 @default.
• W2781054453 cites W2059680237 @default.
• W2781054453 cites W2061882919 @default.
• W2781054453 cites W2063920622 @default.
• W2781054453 cites W2064253235 @default.
• W2781054453 cites W2065023793 @default.
• W2781054453 cites W2065878752 @default.
• W2781054453 cites W2066360065 @default.
• W2781054453 cites W2067505007 @default.
• W2781054453 cites W2072300232 @default.
• W2781054453 cites W2074983104 @default.
• W2781054453 cites W2076800034 @default.
• W2781054453 cites W2077547393 @default.
• W2781054453 cites W2080034260 @default.
• W2781054453 cites W2082554893 @default.
• W2781054453 cites W2082683998 @default.
• W2781054453 cites W2085267754 @default.
• W2781054453 cites W2087277465 @default.
• W2781054453 cites W2090620788 @default.
• W2781054453 cites W2095374759 @default.
• W2781054453 cites W2102256305 @default.
• W2781054453 cites W2105414745 @default.
• W2781054453 cites W2106389606 @default.
• W2781054453 cites W2110524866 @default.
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• W2781054453 cites W2113929972 @default.
• W2781054453 cites W2115884335 @default.
• W2781054453 cites W2124135429 @default.
• W2781054453 cites W2126761857 @default.
• W2781054453 cites W2145923301 @default.
• W2781054453 cites W2166160073 @default.
• W2781054453 cites W2172543713 @default.
• W2781054453 cites W2189444768 @default.
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• W2781054453 doi "https://doi.org/10.1016/j.neuropharm.2017.12.037" @default.
• W2781054453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29274751" @default.
• W2781054453 hasPublicationYear "2018" @default.
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