FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781127622> ?p ?o ?g. }

• W2781127622 endingPage "69" @default.
• W2781127622 startingPage "69" @default.
• W2781127622 abstract "<p><strong>Aim.</strong> The study was designed to evaluate the efficacy of polypeptide neuroprotection using brain protein “Cellex” for prevention of postoperative cognitive dysfunction after cardiac surgery.<br /><strong>Methods.</strong> Our study included 60 patients undergoing elective cardiosurgical operations, who were randomized into two groups. In the “Cellex” group, the patients received 1.0 ml of “Cellex” subcutaneously daily during 8 days, beginning from the preoperative day, while the control group patients were given a saline placebo. The cognitive function was assessed using a Montreal cognitive assessment (MoCA) test on the day before surgery and also at Days 3 and 7 postoperatively. The plasma concentrations of S100b protein were measured before surgery, and at Days 3 and 7. The patients’ gas exchange, hemodynamics and cerebral oxygenation were monitored. In addition, the efficacy of “Cellex” and the severity of cognitive dysfunction were evaluated intraoperatively under cardiopulmonary bypass.<br />Results. The duration of intervention and mechanical ventilation, as well as hemodynamics and cerebral oximetry data did not differ significantly between the groups. There was a transient decline of cognitive functions and an increase in plasma concentration of S100b at Day 3 after surgery in both groups (p&lt;0.05). At Day 7, the MoCA score was still decreased in the control group (p&lt;0.003), but returned to the baseline in the “Cellex” group. These effects became more pronounced after cardiopulmonary bypass. The intraoperative PaCO2 correlated with cerebral oxygenation surgery by the beginning and at the end of surgery (rho = 0.305, p = 0.033 and rho = 0.533; p&lt;0.001). <br />Conclusion. The perioperative use of “Cellex” can attenuate cognitive dysfunction after cardiac surgery, especially when following interventions under cardiopulmonary bypass.</p><p>Received 25 May 2017. Revised 9 November 2017. Accepted 13 November 2017.</p><p><strong>Funding:</strong> The study was carried out with support of the “Farm-Sintez” company’s grant. The money was spent for purchase of the preparation, the authors’ honoraria and purchase of a kit for determining S100b protein concentration. The sponsors’ support had no impact on the study design and data acquisition, analysis and interpretation. The “Farm-Sintez” company’s representatives were not participating in the preparation and publication of the article.</p><p><strong>Conflict of interest:</strong> The study was carried out with support of the “Farm-Sintez” company’s grant.</p><p><strong>Author contributions</strong><br />Conception and study design: M.A. Putanov, M.M. Sokolova, P.I. Lenkin, M.Yu. Kirov <br />Data collection and analysis: M.A. Putanov, M.M. Sokolova, P.I. Lenkin, I.G. Baskakova, A.N. Kiriluk, D.N. Kazarinov, K.M. Checkaya, T.S. Isakova, M.A. Rumyanceva, V.Yu. Slastilin <br />Statistical data analysis: M.M. Sokolova <br />Drafting the article: M.A. Putanov, M.M. Sokolova <br />Critical revision of the article: M.Yu. Kirov <br />Final approval of the version to be published: M.A. Putanov, M.M. Sokolova, P.I. Lenkin, V.Yu. Slastilin, I.G. Baskakova, A.N. Kiriluk, D.N. Kazarinov, K.M. Checkaya, T.S. Isakova, M.A. Rumyanceva, M.Yu. Kirov</p>" @default.
• W2781127622 created "2018-01-05" @default.
• W2781127622 creator A5000629594 @default.
• W2781127622 creator A5003850042 @default.
• W2781127622 creator A5011297486 @default.
• W2781127622 creator A5031346284 @default.
• W2781127622 creator A5031466438 @default.
• W2781127622 creator A5056311675 @default.
• W2781127622 creator A5056984817 @default.
• W2781127622 creator A5068045073 @default.
• W2781127622 creator A5075428463 @default.
• W2781127622 creator A5077707423 @default.
• W2781127622 creator A5006125379 @default.
• W2781127622 date "2017-12-28" @default.
• W2781127622 modified "2023-09-27" @default.
• W2781127622 title "Use of polypeptide neuroprotection for prevention of postoperative cognitive dysfunction after cardiac surgery: a pilot prospective randomized placebo-controlled clinical study" @default.
• W2781127622 doi "https://doi.org/10.21688/1681-3472-2017-4-69-78" @default.
• W2781127622 hasPublicationYear "2017" @default.
• W2781127622 type Work @default.
• W2781127622 sameAs 2781127622 @default.
• W2781127622 citedByCount "0" @default.
• W2781127622 crossrefType "journal-article" @default.
• W2781127622 hasAuthorship W2781127622A5000629594 @default.
• W2781127622 hasAuthorship W2781127622A5003850042 @default.
• W2781127622 hasAuthorship W2781127622A5006125379 @default.
• W2781127622 hasAuthorship W2781127622A5011297486 @default.
• W2781127622 hasAuthorship W2781127622A5031346284 @default.
• W2781127622 hasAuthorship W2781127622A5031466438 @default.
• W2781127622 hasAuthorship W2781127622A5056311675 @default.
• W2781127622 hasAuthorship W2781127622A5056984817 @default.
• W2781127622 hasAuthorship W2781127622A5068045073 @default.
• W2781127622 hasAuthorship W2781127622A5075428463 @default.
• W2781127622 hasAuthorship W2781127622A5077707423 @default.
• W2781127622 hasBestOaLocation W27811276221 @default.
• W2781127622 hasConcept C118552586 @default.
• W2781127622 hasConcept C126322002 @default.
• W2781127622 hasConcept C141071460 @default.
• W2781127622 hasConcept C142724271 @default.
• W2781127622 hasConcept C168563851 @default.
• W2781127622 hasConcept C169900460 @default.
• W2781127622 hasConcept C178853913 @default.
• W2781127622 hasConcept C204787440 @default.
• W2781127622 hasConcept C25498285 @default.
• W2781127622 hasConcept C27081682 @default.
• W2781127622 hasConcept C2775961468 @default.
• W2781127622 hasConcept C2776632958 @default.
• W2781127622 hasConcept C2777397205 @default.
• W2781127622 hasConcept C2778789114 @default.
• W2781127622 hasConcept C2778881276 @default.
• W2781127622 hasConcept C2779134260 @default.
• W2781127622 hasConcept C2780043718 @default.
• W2781127622 hasConcept C2781312054 @default.
• W2781127622 hasConcept C2984915365 @default.
• W2781127622 hasConcept C42219234 @default.
• W2781127622 hasConcept C71924100 @default.
• W2781127622 hasConceptScore W2781127622C118552586 @default.
• W2781127622 hasConceptScore W2781127622C126322002 @default.
• W2781127622 hasConceptScore W2781127622C141071460 @default.
• W2781127622 hasConceptScore W2781127622C142724271 @default.
• W2781127622 hasConceptScore W2781127622C168563851 @default.
• W2781127622 hasConceptScore W2781127622C169900460 @default.
• W2781127622 hasConceptScore W2781127622C178853913 @default.
• W2781127622 hasConceptScore W2781127622C204787440 @default.
• W2781127622 hasConceptScore W2781127622C25498285 @default.
• W2781127622 hasConceptScore W2781127622C27081682 @default.
• W2781127622 hasConceptScore W2781127622C2775961468 @default.
• W2781127622 hasConceptScore W2781127622C2776632958 @default.
• W2781127622 hasConceptScore W2781127622C2777397205 @default.
• W2781127622 hasConceptScore W2781127622C2778789114 @default.
• W2781127622 hasConceptScore W2781127622C2778881276 @default.
• W2781127622 hasConceptScore W2781127622C2779134260 @default.
• W2781127622 hasConceptScore W2781127622C2780043718 @default.
• W2781127622 hasConceptScore W2781127622C2781312054 @default.
• W2781127622 hasConceptScore W2781127622C2984915365 @default.
• W2781127622 hasConceptScore W2781127622C42219234 @default.
• W2781127622 hasConceptScore W2781127622C71924100 @default.
• W2781127622 hasIssue "4" @default.
• W2781127622 hasLocation W27811276221 @default.
• W2781127622 hasLocation W27811276222 @default.
• W2781127622 hasOpenAccess W2781127622 @default.
• W2781127622 hasPrimaryLocation W27811276221 @default.
• W2781127622 hasRelatedWork W1982674655 @default.
• W2781127622 hasRelatedWork W1988697932 @default.
• W2781127622 hasRelatedWork W2049733093 @default.
• W2781127622 hasRelatedWork W2317142598 @default.
• W2781127622 hasRelatedWork W2415978481 @default.
• W2781127622 hasRelatedWork W2778061613 @default.
• W2781127622 hasRelatedWork W2792839382 @default.
• W2781127622 hasRelatedWork W2897781918 @default.
• W2781127622 hasRelatedWork W3031170882 @default.
• W2781127622 hasRelatedWork W4249035289 @default.
• W2781127622 hasVolume "21" @default.
• W2781127622 isParatext "false" @default.
• W2781127622 isRetracted "false" @default.
• W2781127622 magId "2781127622" @default.
• W2781127622 workType "article" @default.