FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781135240> ?p ?o ?g. }

• W2781135240 endingPage "92" @default.
• W2781135240 startingPage "84" @default.
• W2781135240 abstract "Pulmonary arterial hypertension (PAH) is a disease characterized by an elevated pulmonary arterial (PA) pressure. While several computational hemodynamic models of the pulmonary vasculature have been developed to understand PAH, they are lacking in some aspects, such as the vessel wall deformation and its lack of calibration against measurements in humans. Here, we describe a computational modeling framework that addresses these limitations. Specifically, computational models describing the coupling of hemodynamics and vessel wall mechanics in the pulmonary vasculature of a PAH patient and a normal subject were developed. Model parameters, consisting of linearized stiffness E of the large vessels and Windkessel parameters for each outflow branch, were calibrated against in vivo measurements of pressure, flow and vessel wall deformation obtained, respectively, from right-heart catheterization, phase-contrast and cine magnetic resonance images. Calibrated stiffness E of the proximal PA was 2.0 and 0.5 MPa for the PAH and normal models, respectively. Calibrated total compliance CT and resistance RT of the distal vessels were, respectively, 0.32 ml/mmHg and 11.3 mmHg∗min/l for the PAH model, and 2.93 ml/mmHg and 2.6 mmHg∗min/l for the normal model. These results were consistent with previous findings that the pulmonary vasculature is stiffer with more constricted distal vessels in PAH patients. Individual effects on PA pressure due to remodeling of the distal and proximal compartments of the pulmonary vasculature were also investigated in a sensitivity analysis. The analysis suggests that the remodeling of distal vasculature contributes more to the increase in PA pressure than the remodeling of proximal vasculature." @default.
• W2781135240 created "2018-01-05" @default.
• W2781135240 creator A5000835038 @default.
• W2781135240 creator A5003990800 @default.
• W2781135240 creator A5053846283 @default.
• W2781135240 creator A5065422598 @default.
• W2781135240 creator A5071334202 @default.
• W2781135240 creator A5078319431 @default.
• W2781135240 creator A5079207985 @default.
• W2781135240 creator A5080485339 @default.
• W2781135240 date "2018-02-01" @default.
• W2781135240 modified "2023-10-02" @default.
• W2781135240 title "Image-based computational assessment of vascular wall mechanics and hemodynamics in pulmonary arterial hypertension patients" @default.
• W2781135240 cites W1178195163 @default.
• W2781135240 cites W1490886285 @default.
• W2781135240 cites W1968311063 @default.
• W2781135240 cites W1979129486 @default.
• W2781135240 cites W1983332762 @default.
• W2781135240 cites W1986624570 @default.
• W2781135240 cites W2003695291 @default.
• W2781135240 cites W2012893624 @default.
• W2781135240 cites W2022751297 @default.
• W2781135240 cites W2034011164 @default.
• W2781135240 cites W2042273019 @default.
• W2781135240 cites W2042889462 @default.
• W2781135240 cites W2044090992 @default.
• W2781135240 cites W2044871551 @default.
• W2781135240 cites W2053205239 @default.
• W2781135240 cites W2061214074 @default.
• W2781135240 cites W2064752806 @default.
• W2781135240 cites W2071711943 @default.
• W2781135240 cites W2078069441 @default.
• W2781135240 cites W2085545295 @default.
• W2781135240 cites W2088048714 @default.
• W2781135240 cites W2093156343 @default.
• W2781135240 cites W2105370230 @default.
• W2781135240 cites W2111420319 @default.
• W2781135240 cites W2113236035 @default.
• W2781135240 cites W2122979079 @default.
• W2781135240 cites W2136978968 @default.
• W2781135240 cites W2139954704 @default.
• W2781135240 cites W2162526047 @default.
• W2781135240 cites W2168807618 @default.
• W2781135240 cites W2498740932 @default.
• W2781135240 cites W2592923626 @default.
• W2781135240 cites W4211102601 @default.
• W2781135240 cites W4253797853 @default.
• W2781135240 doi "https://doi.org/10.1016/j.jbiomech.2017.12.022" @default.
• W2781135240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5783768" @default.
• W2781135240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29310945" @default.
• W2781135240 hasPublicationYear "2018" @default.
• W2781135240 type Work @default.
• W2781135240 sameAs 2781135240 @default.
• W2781135240 citedByCount "40" @default.
• W2781135240 countsByYear W27811352402019 @default.
• W2781135240 countsByYear W27811352402020 @default.
• W2781135240 countsByYear W27811352402021 @default.
• W2781135240 countsByYear W27811352402022 @default.
• W2781135240 countsByYear W27811352402023 @default.
• W2781135240 crossrefType "journal-article" @default.
• W2781135240 hasAuthorship W2781135240A5000835038 @default.
• W2781135240 hasAuthorship W2781135240A5003990800 @default.
• W2781135240 hasAuthorship W2781135240A5053846283 @default.
• W2781135240 hasAuthorship W2781135240A5065422598 @default.
• W2781135240 hasAuthorship W2781135240A5071334202 @default.
• W2781135240 hasAuthorship W2781135240A5078319431 @default.
• W2781135240 hasAuthorship W2781135240A5079207985 @default.
• W2781135240 hasAuthorship W2781135240A5080485339 @default.
• W2781135240 hasBestOaLocation W27811352402 @default.
• W2781135240 hasConcept C126322002 @default.
• W2781135240 hasConcept C136229726 @default.
• W2781135240 hasConcept C15744967 @default.
• W2781135240 hasConcept C164705383 @default.
• W2781135240 hasConcept C178853913 @default.
• W2781135240 hasConcept C2775850156 @default.
• W2781135240 hasConcept C2780930700 @default.
• W2781135240 hasConcept C2781460075 @default.
• W2781135240 hasConcept C2909948108 @default.
• W2781135240 hasConcept C58245268 @default.
• W2781135240 hasConcept C71924100 @default.
• W2781135240 hasConcept C77805123 @default.
• W2781135240 hasConcept C84393581 @default.
• W2781135240 hasConceptScore W2781135240C126322002 @default.
• W2781135240 hasConceptScore W2781135240C136229726 @default.
• W2781135240 hasConceptScore W2781135240C15744967 @default.
• W2781135240 hasConceptScore W2781135240C164705383 @default.
• W2781135240 hasConceptScore W2781135240C178853913 @default.
• W2781135240 hasConceptScore W2781135240C2775850156 @default.
• W2781135240 hasConceptScore W2781135240C2780930700 @default.
• W2781135240 hasConceptScore W2781135240C2781460075 @default.
• W2781135240 hasConceptScore W2781135240C2909948108 @default.
• W2781135240 hasConceptScore W2781135240C58245268 @default.
• W2781135240 hasConceptScore W2781135240C71924100 @default.
• W2781135240 hasConceptScore W2781135240C77805123 @default.
• W2781135240 hasConceptScore W2781135240C84393581 @default.
• W2781135240 hasFunder F4320332161 @default.
• W2781135240 hasFunder F4320338335 @default.
• W2781135240 hasLocation W27811352401 @default.

• next