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- W2781194958 endingPage "85" @default.
- W2781194958 startingPage "72" @default.
- W2781194958 abstract "About 15% of patients with Parkinson disease (PD) have family history and 5–10% have a monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 disease-causing genes for parkinsonism have been found, but many more genetic risk loci and variants for sporadic PD phenotype have been identified in various association studies. Investigating the mutated protein products has uncovered potential pathogenic pathways that provide insights into mechanisms of neurodegeneration in familial and sporadic PD. To commemorate the 200th anniversary of Parkinson’s publication of An Essay on the Shaking Palsy, we provide a comprehensive and critical overview of the current clinical, neuropathological, and genetic understanding of genetic forms of PD. We also discuss advances in screening for genetic PD-related risk factors and how they impact genetic counseling and contribute to the development of potential disease-modifying therapies." @default.
- W2781194958 created "2018-01-05" @default.
- W2781194958 creator A5029427154 @default.
- W2781194958 creator A5060753195 @default.
- W2781194958 creator A5068655451 @default.
- W2781194958 date "2018-03-01" @default.
- W2781194958 modified "2023-10-16" @default.
- W2781194958 title "The genetics of Parkinson disease" @default.
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