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• W2781374920 abstract "Mercury and its derivatives even in small concentration may cause a major human health problem. Though not reported in detail, there are various aquatic bacterial species that produce small quantities of methyl mercury (MM) growing under aerobic conditions. Consumption of food derived from sources contaminated with such bacteria within therapeutic doses and exposure to different forms of MM compounds through such sources may induce substantial toxic effects. In the present study, the perinatal oral exposure of pregnant mice to two strains of mercury resistant bacteria (MRB), Aeromonas KSU5 MRB and KSU6 MRB resulted in a significant reduction in postnatal body weight gain, delays in the opening of the eyes and appearance in the body hair fuzz, and deficits in the developing sensory motor reflexes in the mice pups during their weaning period on post-natal day (PD)7, PD14 and PD21. A significant and MM producing concentration-dependent disturbance in the levels of neurotransmitters like dopamine (DA) and serotonin (5-HT); non-enzymatic oxidative stress (OS) indices like thiobarbituric acid-reactive substances (TBARS) and total reduced glutathione (GSH); and enzymatic OS indices like glutathione S-transferase (GST), catalase (CAT), and superoxide dismutase (SOD) were observed in the forebrain region of the offspring at weaning period (PD7, PD14, and PD21), at adolescent age (PD30), and at adult age (PD36). Thus, perinatal exposure to MRB can affect developing fetus, raising the concerns for it's potential neurotoxic hazards. A reduced exposure to mercury during pregnancy is of crucial importance in preventing mercury-induced neurotoxicity in the offspring." @default.
• W2781374920 created "2018-01-05" @default.
• W2781374920 creator A5028019186 @default.
• W2781374920 date "2018-01-01" @default.
• W2781374920 modified "2023-10-05" @default.
• W2781374920 title "Mercuric resistant bacteria Aeromonas exhibits neurologic toxic effects on the developmental motor reflexes, and brain oxidative stress in mice offspring" @default.
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• W2781374920 doi "https://doi.org/10.1016/j.micpath.2017.11.063" @default.
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