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- W2781454027 abstract "Macrolide antibiotics have a range of immunomodulatory properties, which may influence clinical outcomes such as reduced exacerbations in patients with airways disease. Azithromycin (AZM) has been shown to reduce IL-1β release from blood monocytes, however little is known about the impact of AZM therapy on airway IL-1β. We tested the hypothesis that AZM would reduce sputum IL-1β and that this reduction would be associated with a reduction in sputum neutrophils. Induced Sputum collected from a randomized double-blind placebo controlled trial of oral AZM (500mg, 3 times weekly, 48 weeks) in adults with symptomatic asthma was dispersed using dithiothreitol and supernatant collected and assessed for IL-1β using ELISA in 195 paired samples. There was a significant reduction in sputum IL-1β following AZM therapy (median 398ng/mL at baseline to 168ng/mL following treatment, p=0.003). A significant reduction was observed in both eosinophilic (EA) and non-eosinophilic (NEA) participants, however, those with NEA had a three-fold larger reduction in IL-1β following AZM compared with EA, median change 234 ng/mL vs. 72 ng/mL, p=0.028. Baseline IL-1β was significantly positively associated with baseline neutrophil number in all participants (r = 0.499, p Sputum IL-1β was significantly reduced following AZM add-on therapy in poorly controlled asthma irrespective of baseline asthma phenotype." @default.
- W2781454027 created "2018-01-05" @default.
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- W2781454027 date "2017-09-01" @default.
- W2781454027 modified "2023-09-23" @default.
- W2781454027 title "Sputum IL-1β is reduced with Azithromycin add-on therapy in patients with poorly controlled asthma" @default.
- W2781454027 doi "https://doi.org/10.1183/1393003.congress-2017.pa4029" @default.
- W2781454027 hasPublicationYear "2017" @default.
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