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• W2781489787 abstract "<ns4:p>Macrophages (MØs) are a key cell type of both the innate and the adaptive immune response and can tailor their response to prevailing conditions. To sense the host’s status, MØs employ two classes of receptors: Toll-like receptors (TLRs), which are sensors for pathogen-derived material, and Fcγ receptors (FcγRs) that are detectors of the adaptive immune response. How MØs integrate the input from these various sensors is not understood and is the focus of active study. Here, we review the recent literature on the molecular mechanisms of TLR and FcgR crosstalk and synergy, and discuss the implications of these findings. This overview suggests a multilayered mechanism of receptor synergy that allows the MØ to fine-tune its response to prevailing conditions and provides ideas for future investigation.</ns4:p>" @default.
• W2781489787 created "2018-01-12" @default.
• W2781489787 creator A5001272863 @default.
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• W2781489787 date "2018-01-08" @default.
• W2781489787 modified "2023-10-15" @default.
• W2781489787 title "Molecular mechanisms of macrophage Toll-like receptor–Fc receptor synergy" @default.
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• W2781489787 doi "https://doi.org/10.12688/f1000research.12679.1" @default.
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• W2781489787 hasPublicationYear "2018" @default.
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