FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781490373> ?p ?o ?g. }

• W2781490373 endingPage "63" @default.
• W2781490373 startingPage "54" @default.
• W2781490373 abstract "Progression of solid cancers, colorectal carcinomas among them, from their primaries to metastatic lesions traditionally is thought to proceed by a stepwise acquisition of and selection for genomic aberrations. To test if patterns of genomic aberrations would be consistent with this model, we studied 10 colorectal carcinoma primary-metastasis pairs, 9 with 1 liver metastasis each and 1 with 2 metastases. Next-generation targeted sequencing (50-gene panel) with samples obtained from different regions of the primaries and their metastases demonstrated 1-11 gene mutations per lesion. But only in 2 tumors were there seen mutations in all samples from the metastasis and not any of the primaries (BRAFD594N and SMARCB1R377C mutation, respectively). However, allelotyping the multiregional samples with polymorphous microsatellite markers (17p13.1, D9S942, D9S1748, D5S346, D5S1385) and DNA methylation studies with a marker panel (MLH1, CDNK2A, NEUROG1, CRABP1, CACNA1G, IGF2, RUNX3, SOCS1) showed remarkably insular genomic aberrations in all cases for at least some of the analyses. The marked preponderance of mutations shared by the primaries and their metastases throughout the lesions over mutations private to metastases suggests that, at least in many cases, colorectal carcinomas might be endowed with a mutational load sufficient for fully fledged metastases even at a very early stage (born bad). But the very focal allelic imbalances and methylations observed here, hypothetically, could play a role in clinically metastasizing disease, a process of years rather than months and very much a matter of tumor-host interactions when tumor cells adapt to the host microenvironment." @default.
• W2781490373 created "2018-01-12" @default.
• W2781490373 creator A5003866771 @default.
• W2781490373 creator A5036426091 @default.
• W2781490373 creator A5073556275 @default.
• W2781490373 creator A5079524945 @default.
• W2781490373 date "2018-04-01" @default.
• W2781490373 modified "2023-09-25" @default.
• W2781490373 title "Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain?" @default.
• W2781490373 cites W1544851750 @default.
• W2781490373 cites W1970413157 @default.
• W2781490373 cites W1991225025 @default.
• W2781490373 cites W2010873488 @default.
• W2781490373 cites W2011998536 @default.
• W2781490373 cites W2044295151 @default.
• W2781490373 cites W2059492365 @default.
• W2781490373 cites W2080264320 @default.
• W2781490373 cites W2085709573 @default.
• W2781490373 cites W2087744627 @default.
• W2781490373 cites W2091435899 @default.
• W2781490373 cites W2093001213 @default.
• W2781490373 cites W2105307866 @default.
• W2781490373 cites W2128146359 @default.
• W2781490373 cites W2135163856 @default.
• W2781490373 cites W2135449254 @default.
• W2781490373 cites W2138022504 @default.
• W2781490373 cites W2262414037 @default.
• W2781490373 cites W2364449803 @default.
• W2781490373 cites W4238448376 @default.
• W2781490373 cites W4240237951 @default.
• W2781490373 doi "https://doi.org/10.1016/j.humpath.2017.12.015" @default.
• W2781490373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29307628" @default.
• W2781490373 hasPublicationYear "2018" @default.
• W2781490373 type Work @default.
• W2781490373 sameAs 2781490373 @default.
• W2781490373 citedByCount "13" @default.
• W2781490373 countsByYear W27814903732018 @default.
• W2781490373 countsByYear W27814903732019 @default.
• W2781490373 countsByYear W27814903732020 @default.
• W2781490373 countsByYear W27814903732021 @default.
• W2781490373 countsByYear W27814903732022 @default.
• W2781490373 countsByYear W27814903732023 @default.
• W2781490373 crossrefType "journal-article" @default.
• W2781490373 hasAuthorship W2781490373A5003866771 @default.
• W2781490373 hasAuthorship W2781490373A5036426091 @default.
• W2781490373 hasAuthorship W2781490373A5073556275 @default.
• W2781490373 hasAuthorship W2781490373A5079524945 @default.
• W2781490373 hasConcept C104317684 @default.
• W2781490373 hasConcept C111425858 @default.
• W2781490373 hasConcept C121608353 @default.
• W2781490373 hasConcept C142724271 @default.
• W2781490373 hasConcept C143589142 @default.
• W2781490373 hasConcept C180754005 @default.
• W2781490373 hasConcept C2779013556 @default.
• W2781490373 hasConcept C2779767149 @default.
• W2781490373 hasConcept C2780283643 @default.
• W2781490373 hasConcept C501734568 @default.
• W2781490373 hasConcept C502942594 @default.
• W2781490373 hasConcept C526805850 @default.
• W2781490373 hasConcept C54355233 @default.
• W2781490373 hasConcept C60748783 @default.
• W2781490373 hasConcept C61320498 @default.
• W2781490373 hasConcept C71924100 @default.
• W2781490373 hasConcept C86803240 @default.
• W2781490373 hasConceptScore W2781490373C104317684 @default.
• W2781490373 hasConceptScore W2781490373C111425858 @default.
• W2781490373 hasConceptScore W2781490373C121608353 @default.
• W2781490373 hasConceptScore W2781490373C142724271 @default.
• W2781490373 hasConceptScore W2781490373C143589142 @default.
• W2781490373 hasConceptScore W2781490373C180754005 @default.
• W2781490373 hasConceptScore W2781490373C2779013556 @default.
• W2781490373 hasConceptScore W2781490373C2779767149 @default.
• W2781490373 hasConceptScore W2781490373C2780283643 @default.
• W2781490373 hasConceptScore W2781490373C501734568 @default.
• W2781490373 hasConceptScore W2781490373C502942594 @default.
• W2781490373 hasConceptScore W2781490373C526805850 @default.
• W2781490373 hasConceptScore W2781490373C54355233 @default.
• W2781490373 hasConceptScore W2781490373C60748783 @default.
• W2781490373 hasConceptScore W2781490373C61320498 @default.
• W2781490373 hasConceptScore W2781490373C71924100 @default.
• W2781490373 hasConceptScore W2781490373C86803240 @default.
• W2781490373 hasLocation W27814903731 @default.
• W2781490373 hasLocation W27814903732 @default.
• W2781490373 hasOpenAccess W2781490373 @default.
• W2781490373 hasPrimaryLocation W27814903731 @default.
• W2781490373 hasRelatedWork W1984307543 @default.
• W2781490373 hasRelatedWork W1996241776 @default.
• W2781490373 hasRelatedWork W2037071336 @default.
• W2781490373 hasRelatedWork W2044386531 @default.
• W2781490373 hasRelatedWork W2094390470 @default.
• W2781490373 hasRelatedWork W2098153995 @default.
• W2781490373 hasRelatedWork W2129184772 @default.
• W2781490373 hasRelatedWork W2810280598 @default.
• W2781490373 hasRelatedWork W2986202884 @default.
• W2781490373 hasRelatedWork W2052486756 @default.
• W2781490373 hasVolume "74" @default.
• W2781490373 isParatext "false" @default.
• W2781490373 isRetracted "false" @default.

• next