FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781558996> ?p ?o ?g. }

• W2781558996 endingPage "607" @default.
• W2781558996 startingPage "600" @default.
• W2781558996 abstract "Aims α-Fetoprotein (AFP)-producing gastric carcinoma (AFPGC) is one of the most aggressive GC subtypes. Frequent expression of human epidermal growth factor receptor 2 (HER2) has previously been reported in hepatoid adenocarcinoma (HAC), a major histological subtype of AFPGC originating from common-type GC (CGC). However, HER2 expression levels in other AFPGC histological subtypes are unknown. In this study, we analysed HER2 expression in GCs with primitive phenotypes in addition to HAC. Methods HER2 expression was evaluated in representative complete sections from 16 HACs, 19 GCs with enteroblastic differentiation (GCEDs) and 334 GCs of other histological types as controls. The Ruschoff/Hofmann method was used to score HER2 immunohistochemistry. Samples with a HER2 score of 2+ were further assessed using fluorescence in situ hybridisation. Oncofetal protein (OFP) expression in HAC and GCED was tested via immunohistochemical staining for AFP, glypican 3 and Sal-like protein 4. Results Thirty of 35 HAC/GCED cases comprised more than two histological patterns. The HER2 positivity rates of each histological component in the HACs/GCEDs were 25.0% for HAC (n=16), 34.6% for GCED (n=26) and 48.1% for CGC (n=27), which were higher than those of the control group (13.8%). Additionally, the majority of CGC components in HACs/GCEDs were positive for OFP (88.9%). Conclusions HER2 is frequently overexpressed not only in HAC but also in GCED and CGC components of HACs/GCEDs, which suggests an association between HER2 and OFP expression. Moreover, our findings suggest that HER2-positive CGC has a higher risk of progression to HAC/GCED than HER2-negative GC." @default.
• W2781558996 created "2018-01-12" @default.
• W2781558996 creator A5013691190 @default.
• W2781558996 creator A5017125456 @default.
• W2781558996 creator A5027385514 @default.
• W2781558996 creator A5027491309 @default.
• W2781558996 creator A5032943243 @default.
• W2781558996 creator A5038337339 @default.
• W2781558996 creator A5054030262 @default.
• W2781558996 creator A5061632795 @default.
• W2781558996 date "2018-01-05" @default.
• W2781558996 modified "2023-10-17" @default.
• W2781558996 title "HER2 is frequently overexpressed in hepatoid adenocarcinoma and gastric carcinoma with enteroblastic differentiation: a comparison of 35 cases to 334 gastric carcinomas of other histological types" @default.
• W2781558996 cites W1176709326 @default.
• W2781558996 cites W1577685943 @default.
• W2781558996 cites W1972482349 @default.
• W2781558996 cites W1982016639 @default.
• W2781558996 cites W1983940794 @default.
• W2781558996 cites W1987009448 @default.
• W2781558996 cites W1987991390 @default.
• W2781558996 cites W1992898757 @default.
• W2781558996 cites W2013035436 @default.
• W2781558996 cites W2015396326 @default.
• W2781558996 cites W2016283072 @default.
• W2781558996 cites W2038300755 @default.
• W2781558996 cites W2064394610 @default.
• W2781558996 cites W2071425961 @default.
• W2781558996 cites W2074488907 @default.
• W2781558996 cites W2081108170 @default.
• W2781558996 cites W2090542069 @default.
• W2781558996 cites W2091448280 @default.
• W2781558996 cites W2099421298 @default.
• W2781558996 cites W2100439220 @default.
• W2781558996 cites W2104694188 @default.
• W2781558996 cites W2111629517 @default.
• W2781558996 cites W2126547130 @default.
• W2781558996 cites W2136197678 @default.
• W2781558996 cites W2169197097 @default.
• W2781558996 cites W2261487363 @default.
• W2781558996 cites W2274155363 @default.
• W2781558996 cites W2289732113 @default.
• W2781558996 cites W2305869078 @default.
• W2781558996 cites W2320762493 @default.
• W2781558996 cites W2324544062 @default.
• W2781558996 cites W2324981320 @default.
• W2781558996 cites W2515968420 @default.
• W2781558996 cites W2519607828 @default.
• W2781558996 cites W2558528971 @default.
• W2781558996 cites W2613024755 @default.
• W2781558996 cites W2744569257 @default.
• W2781558996 doi "https://doi.org/10.1136/jclinpath-2017-204928" @default.
• W2781558996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29305518" @default.
• W2781558996 hasPublicationYear "2018" @default.
• W2781558996 type Work @default.
• W2781558996 sameAs 2781558996 @default.
• W2781558996 citedByCount "28" @default.
• W2781558996 countsByYear W27815589962019 @default.
• W2781558996 countsByYear W27815589962020 @default.
• W2781558996 countsByYear W27815589962021 @default.
• W2781558996 countsByYear W27815589962022 @default.
• W2781558996 countsByYear W27815589962023 @default.
• W2781558996 crossrefType "journal-article" @default.
• W2781558996 hasAuthorship W2781558996A5013691190 @default.
• W2781558996 hasAuthorship W2781558996A5017125456 @default.
• W2781558996 hasAuthorship W2781558996A5027385514 @default.
• W2781558996 hasAuthorship W2781558996A5027491309 @default.
• W2781558996 hasAuthorship W2781558996A5032943243 @default.
• W2781558996 hasAuthorship W2781558996A5038337339 @default.
• W2781558996 hasAuthorship W2781558996A5054030262 @default.
• W2781558996 hasAuthorship W2781558996A5061632795 @default.
• W2781558996 hasConcept C121608353 @default.
• W2781558996 hasConcept C126322002 @default.
• W2781558996 hasConcept C142724271 @default.
• W2781558996 hasConcept C204232928 @default.
• W2781558996 hasConcept C2776869981 @default.
• W2781558996 hasConcept C2777546739 @default.
• W2781558996 hasConcept C2777701055 @default.
• W2781558996 hasConcept C2781182431 @default.
• W2781558996 hasConcept C3019217517 @default.
• W2781558996 hasConcept C71924100 @default.
• W2781558996 hasConcept C74864618 @default.
• W2781558996 hasConcept C86803240 @default.
• W2781558996 hasConceptScore W2781558996C121608353 @default.
• W2781558996 hasConceptScore W2781558996C126322002 @default.
• W2781558996 hasConceptScore W2781558996C142724271 @default.
• W2781558996 hasConceptScore W2781558996C204232928 @default.
• W2781558996 hasConceptScore W2781558996C2776869981 @default.
• W2781558996 hasConceptScore W2781558996C2777546739 @default.
• W2781558996 hasConceptScore W2781558996C2777701055 @default.
• W2781558996 hasConceptScore W2781558996C2781182431 @default.
• W2781558996 hasConceptScore W2781558996C3019217517 @default.
• W2781558996 hasConceptScore W2781558996C71924100 @default.
• W2781558996 hasConceptScore W2781558996C74864618 @default.
• W2781558996 hasConceptScore W2781558996C86803240 @default.
• W2781558996 hasIssue "7" @default.
• W2781558996 hasLocation W27815589961 @default.
• W2781558996 hasLocation W27815589962 @default.
• W2781558996 hasOpenAccess W2781558996 @default.

• next