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• W2781567656 abstract "Clostridium difficile is the leading cause of antibiotic-associated diarrhoea, both in healthcare facilities and in the community. The recurrence rate of C. difficile infection (CDI) remains high, up to 20%. Since the publication of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidance document on CDI treatment in 2014, new therapeutic approaches have been developed and tested to achieve higher sustained clinical cure in CDI.To review novel treatments and approaches for CDI, except probiotics and vaccines. We focused on new antibiotics, antibiotic inactivators, monoclonal antibodies and gut microbiota modulating therapies.A literature review was performed for clinical trials published in PubMed, Embase or Cochrane Library between January 2013 and November 2017.We analysed 28 clinical trials and identified 14 novel agents. Completed phase 2 studies were found for cadazolid, LFF571, ridinilazole and nontoxigenic C. difficile strains. Four phase 3 active comparator studies comparing vancomycin with bezlotoxumab, surotomycin (n = 2) and rifaximin have been published. Seven clinical trials for treatment of multiple recurrent CDI with faecal microbiota transplantation were analysed, describing faecal microbiota transplantation by upper or lower gastrointestinal route (n = 5) or by capsules (n = 2).Metronidazole is mentioned in the ESCMID guideline as first-line therapy, but we propose that oral vancomycin will become the first choice when antibiotic treatment for CDI is necessary. Fidaxomicin is a good alternative, especially in patients at risk of relapse. Vancomycin combined with faecal microbiota transplantation remains the primary therapy for multiple recurrent CDI. We anticipate that new medication that protects the gut microbiota will be further developed and tested to prevent CDI during antibiotic therapy." @default.
• W2781567656 created "2018-01-12" @default.
• W2781567656 creator A5036206274 @default.
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• W2781567656 date "2018-05-01" @default.
• W2781567656 modified "2023-10-14" @default.
• W2781567656 title "Update of treatment algorithms for Clostridium difficile infection" @default.
• W2781567656 cites W1543317050 @default.
• W2781567656 cites W1916481354 @default.
• W2781567656 cites W1943950351 @default.
• W2781567656 cites W1963566355 @default.
• W2781567656 cites W1967283617 @default.
• W2781567656 cites W1969939375 @default.
• W2781567656 cites W1993830991 @default.
• W2781567656 cites W1996273713 @default.
• W2781567656 cites W2002132748 @default.
• W2781567656 cites W2003497105 @default.
• W2781567656 cites W2012852554 @default.
• W2781567656 cites W2049511418 @default.
• W2781567656 cites W2051510344 @default.
• W2781567656 cites W2057756500 @default.
• W2781567656 cites W2069670597 @default.
• W2781567656 cites W2075288664 @default.
• W2781567656 cites W2076279677 @default.
• W2781567656 cites W2082889349 @default.
• W2781567656 cites W2104815174 @default.
• W2781567656 cites W2106245002 @default.
• W2781567656 cites W2107961033 @default.
• W2781567656 cites W2108975442 @default.
• W2781567656 cites W2114314510 @default.
• W2781567656 cites W2116355501 @default.
• W2781567656 cites W2119031245 @default.
• W2781567656 cites W2119114528 @default.
• W2781567656 cites W2128753169 @default.
• W2781567656 cites W2129747560 @default.
• W2781567656 cites W2131038214 @default.
• W2781567656 cites W2137408524 @default.
• W2781567656 cites W2138430214 @default.
• W2781567656 cites W2139607253 @default.
• W2781567656 cites W2144370711 @default.
• W2781567656 cites W2147511770 @default.
• W2781567656 cites W2148171446 @default.
• W2781567656 cites W2150765371 @default.
• W2781567656 cites W2155800098 @default.
• W2781567656 cites W2157440534 @default.
• W2781567656 cites W2158871837 @default.
• W2781567656 cites W2159633774 @default.
• W2781567656 cites W2161590746 @default.
• W2781567656 cites W2166660180 @default.
• W2781567656 cites W2167805911 @default.
• W2781567656 cites W2169854262 @default.
• W2781567656 cites W2170009866 @default.
• W2781567656 cites W2174455357 @default.
• W2781567656 cites W2182683962 @default.
• W2781567656 cites W2184942857 @default.
• W2781567656 cites W2194277343 @default.
• W2781567656 cites W2197849900 @default.
• W2781567656 cites W2218480779 @default.
• W2781567656 cites W2276111277 @default.
• W2781567656 cites W2286053779 @default.
• W2781567656 cites W2298483969 @default.
• W2781567656 cites W2319922781 @default.
• W2781567656 cites W2344827342 @default.
• W2781567656 cites W2414830383 @default.
• W2781567656 cites W2419496077 @default.
• W2781567656 cites W2481459393 @default.
• W2781567656 cites W2501981640 @default.
• W2781567656 cites W2509510848 @default.
• W2781567656 cites W2509716797 @default.
• W2781567656 cites W2512704070 @default.
• W2781567656 cites W2525392288 @default.
• W2781567656 cites W2547815244 @default.
• W2781567656 cites W2550586225 @default.
• W2781567656 cites W2551264568 @default.
• W2781567656 cites W2557388592 @default.
• W2781567656 cites W2567760185 @default.
• W2781567656 cites W2582069104 @default.
• W2781567656 cites W2586221198 @default.
• W2781567656 cites W2586856271 @default.
• W2781567656 cites W2588484778 @default.
• W2781567656 cites W2593442174 @default.
• W2781567656 cites W2594134989 @default.
• W2781567656 cites W2608048982 @default.
• W2781567656 cites W2611907043 @default.
• W2781567656 cites W2616731084 @default.
• W2781567656 cites W2620729625 @default.
• W2781567656 cites W2622252261 @default.
• W2781567656 cites W2684807067 @default.
• W2781567656 cites W2735259022 @default.
• W2781567656 cites W2749107782 @default.
• W2781567656 cites W2752378836 @default.
• W2781567656 cites W2769536540 @default.

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