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• W2781569492 abstract "// Nan Song 1 , Aesun Shin 1, 2, 3, * , Jae Hwan Oh 4 and Jeongseon Kim 3, * 1 Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea 2 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea 3 Molecular Epidemiology Branch, National Cancer Center, Goyang, Korea 4 Center for Colorectal Cancer, National Cancer Center, Goyang, Korea * These authors have contributed equally to this work Correspondence to: Aesun Shin, email: shinaesun@snu.ac.kr Jeongseon Kim, email: jskim@ncc.re.kr Keywords: colorectal cancer; gene and environment interaction; single-nucleotide polymorphism; alcohol consumption; case-control study Received: June 01, 2017     Accepted: December 28, 2017     Published: January 06, 2018 ABSTRACT Background: Genome-wide association studies (GWAS) have identified approximately 40 common genetic loci associated with colorectal cancer risk. To investigate possible gene-environment interactions (GEIs) between GWAS-identified single-nucleotide polymorphisms (SNPs) and alcohol consumption with respect to colorectal cancer, a hospital-based case-control study was conducted. Results: Higher levels of alcohol consumption as calculated based on a standardized definition of a drink (1 drink=12.5g of ethanol) were associated with increased risk of colorectal cancer (OR=2.47, 95% CI=1.62-3.76 for heavy drinkers [>50g/day] compared to never drinkers; p trend <0.01). SNP rs6687758 near the DUSP10 gene at 1q41 had a statistically significant interaction with alcohol consumption in analyses of standardized drinks ( p =4.6×10 -3 ), although this did not surpass the corrected threshold for multiple testing. When stratified by alcohol consumption levels, in an additive model the risk of colorectal cancer associated with the G allele of rs6687758 tended to increase among individuals in the heavier alcohol consumption strata. A statistically significant association between rs6687758 and colorectal cancer risk was observed among moderate alcohol drinkers who consumed between >12.5 and ≤50g of alcohol per day (OR=1.46, 95% CI=1.01-2.11). Methods: A total of 2,109 subjects (703 colorectal cancer patients and 1,406 healthy controls) were recruited from the Korean National Cancer Center. For genotyping, 30 GWAS-identified SNPs were selected. A logistic regression model was used to evaluate associations of SNPs and alcohol consumption with colorectal cancer risk. We also tested GEIs between SNPs and alcohol consumption using a logistic model with multiplicative interaction terms. Conclusions: Our results suggest that SNP rs6687758 at 1q41 may interact with alcohol consumption in the etiology of colorectal cancer." @default.
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• W2781569492 date "2018-01-06" @default.
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• W2781569492 title "Effects of interactions between common genetic variants and alcohol consumption on colorectal cancer risk" @default.
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• W2781569492 doi "https://doi.org/10.18632/oncotarget.23997" @default.
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