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• W2781592989 abstract "// Haochang Hu 1, * , Bin Li 1, * , Cong Zhou 1, * , Xiuru Ying 1, * , Min Chen 1 , Tianyi Huang 1 , Yuehong Chen 1 , Huihui Ji 1 , Ranran Pan 1 , Tiangong Wang 1 , Danjie Jiang 1 , Yanfei Chen 1 , Yong Yang 1 and Shiwei Duan 1 1 Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang, China * These authors are co-first authors of this work Correspondence to: Shiwei Duan, email: duanshiwei@nbu.edu.cn Keywords: DNA methylation; colorectal cancer; WIF1; diagnostic value; meta-analysis Received: August 09, 2017      Accepted: December 23, 2017      Published: January 03, 2018 ABSTRACT As a common antagonist of Wnt/β-catenin signaling, Wnt inhibitory factor 1 ( WIF1 ) plays an important role in the tumor progression. The aim of our meta-analysis was to summarize the diagnostic value of WIF1 methylation in colorectal cancer (CRC). Eligible studies were retrieved by a systemic search among PubMed, Embase, CNKI, and Wanfang literature databases. The diagnostic value of WIF1 methylation for CRC was assessed by the summary receiver operating characteristics (SROC) test. Our meta-analysis of 12 studies between 1420 CRC samples and 946 control samples showed that WIF1 hypermethylation was significantly associated with CRC ( P < 0.001, OR = 30.10, 95% CI = 19.48-46.50). WIF1 hypermethylation, as a diagnostic biomarker for CRC, has a pooled sensitivity of 0.40 (95% CI: 0.37-0.42), a pooled specificity of 0.95 (95% CI: 0.93-0.96), a pooled positive-likelihood ratio (PLR) of 8.65 (95% CI, 4.47-16.73), and a pooled negative-likelihood ratio (NLR) of 0.41 (95% CI, 0.30-0.55), a diagnostic odds ratio (DOR) of 26.86 (95% CI: 15.73-45.89), and an area under the curve (AUC) of 0.9115. In conclusion, our study established that WIF1 hypermethylation might be a promising diagnostic biomarker for CRC." @default.
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• W2781592989 date "2018-01-03" @default.
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• W2781592989 title "Diagnostic value of <i>WIF1</i> methylation for colorectal cancer: a meta-analysis" @default.
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• W2781592989 doi "https://doi.org/10.18632/oncotarget.23870" @default.
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