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- W2781599883 abstract "Abstract During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by β-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance plasmid that harbors genes encoding additional resistances to aminoglycosides (aacA-aphD, aphA, and aadK) as well as macrolides (ermB) and tetracyclines (tetS). This further plasmidborne β-lactam resistance mechanism harbors the putative risk of acceleration or reacceleration of MRSA spread, resulting in broad ineffectiveness of β-lactams as a main therapeutic application against staphylococcal infections." @default.
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- W2781599883 date "2018-02-01" @default.
- W2781599883 modified "2023-10-11" @default.
- W2781599883 title "Plasmid-Encoded Transferable<i>mecB</i>-Mediated Methicillin Resistance in<i>Staphylococcus aureus</i>" @default.
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- W2781599883 doi "https://doi.org/10.3201/eid2402.171074" @default.
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