Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781750079> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2781750079 endingPage "S58" @default.
- W2781750079 startingPage "S58" @default.
- W2781750079 abstract "The purpose of this study was to evaluate outcomes for patients with positive cell free DNA GENOME studies in order to better understand how helpful these results are in affecting patient management. This is a retrospective descriptive study reviewing all patients at our institution who underwent MaterniT GENOME testing. GENOME testing was made available to high risk patients presenting for genetic counseling starting November 2015 to May 2017. Patients undergoing cell free DNA testing could choose to undergo either MaterniT21 PLUS Core with sex chromosome aneuploidies (C) (testing for trisomy 13, 18, 21 and sex aneuploidies) or MaterniT GENOME (G) (genome wide fetal aneuploidy testing). For this study we analyzed those choosing to undergo MaterniT GENOME. From November 2015 to May 2017, 495 patients (42%) chose Core testing, and 671 (58%) chose GENOME. Of the 671 patients who chose GENOME, 29 patients (4.3%) had abnormal results (Image 1). Eighteen of these (2.7%) had positive results that would have been detected from the more basic testing (C), while 11 (1.6%) had abnormalities found specifically due to the GENOME testing(G). The table lists the abnormalities detected on GENOME testing and the outcomes of these pregnancies (Table 1). Four patients had spontaneous miscarriages; six of the seven remaining patients had amniocentesis, 5 of which had normal results. Four of the seven patients delivered healthy infants, while the other 3 had either a preterm delivery or growth restriction. Overall, 3 out of the 671 patients (0.004%) had GENOME results that were relevant to antenatal management. At this time GENOME testing can lead to false positive results and adds little to Core (C) cell free DNA testing. GENOME results rarely affect management and a true assessment of risks, benefits, and cost needs to be determined.View Large Image Figure ViewerDownload Hi-res image Download (PPT)" @default.
- W2781750079 created "2018-01-12" @default.
- W2781750079 creator A5020817371 @default.
- W2781750079 creator A5031657654 @default.
- W2781750079 creator A5041024834 @default.
- W2781750079 creator A5046435717 @default.
- W2781750079 creator A5054595083 @default.
- W2781750079 creator A5071760973 @default.
- W2781750079 creator A5079954361 @default.
- W2781750079 creator A5081461440 @default.
- W2781750079 date "2018-01-01" @default.
- W2781750079 modified "2023-10-18" @default.
- W2781750079 title "79: How much is too much when it comes to cell free DNA GENOME testing?" @default.
- W2781750079 doi "https://doi.org/10.1016/j.ajog.2017.10.490" @default.
- W2781750079 hasPublicationYear "2018" @default.
- W2781750079 type Work @default.
- W2781750079 sameAs 2781750079 @default.
- W2781750079 citedByCount "0" @default.
- W2781750079 crossrefType "journal-article" @default.
- W2781750079 hasAuthorship W2781750079A5020817371 @default.
- W2781750079 hasAuthorship W2781750079A5031657654 @default.
- W2781750079 hasAuthorship W2781750079A5041024834 @default.
- W2781750079 hasAuthorship W2781750079A5046435717 @default.
- W2781750079 hasAuthorship W2781750079A5054595083 @default.
- W2781750079 hasAuthorship W2781750079A5071760973 @default.
- W2781750079 hasAuthorship W2781750079A5079954361 @default.
- W2781750079 hasAuthorship W2781750079A5081461440 @default.
- W2781750079 hasBestOaLocation W27817500791 @default.
- W2781750079 hasConcept C104317684 @default.
- W2781750079 hasConcept C126322002 @default.
- W2781750079 hasConcept C131872663 @default.
- W2781750079 hasConcept C141231307 @default.
- W2781750079 hasConcept C152110520 @default.
- W2781750079 hasConcept C172680121 @default.
- W2781750079 hasConcept C197077220 @default.
- W2781750079 hasConcept C2776229224 @default.
- W2781750079 hasConcept C2777966818 @default.
- W2781750079 hasConcept C2778258057 @default.
- W2781750079 hasConcept C2779234561 @default.
- W2781750079 hasConcept C2779672484 @default.
- W2781750079 hasConcept C2780673598 @default.
- W2781750079 hasConcept C30481170 @default.
- W2781750079 hasConcept C54355233 @default.
- W2781750079 hasConcept C71924100 @default.
- W2781750079 hasConcept C86803240 @default.
- W2781750079 hasConceptScore W2781750079C104317684 @default.
- W2781750079 hasConceptScore W2781750079C126322002 @default.
- W2781750079 hasConceptScore W2781750079C131872663 @default.
- W2781750079 hasConceptScore W2781750079C141231307 @default.
- W2781750079 hasConceptScore W2781750079C152110520 @default.
- W2781750079 hasConceptScore W2781750079C172680121 @default.
- W2781750079 hasConceptScore W2781750079C197077220 @default.
- W2781750079 hasConceptScore W2781750079C2776229224 @default.
- W2781750079 hasConceptScore W2781750079C2777966818 @default.
- W2781750079 hasConceptScore W2781750079C2778258057 @default.
- W2781750079 hasConceptScore W2781750079C2779234561 @default.
- W2781750079 hasConceptScore W2781750079C2779672484 @default.
- W2781750079 hasConceptScore W2781750079C2780673598 @default.
- W2781750079 hasConceptScore W2781750079C30481170 @default.
- W2781750079 hasConceptScore W2781750079C54355233 @default.
- W2781750079 hasConceptScore W2781750079C71924100 @default.
- W2781750079 hasConceptScore W2781750079C86803240 @default.
- W2781750079 hasIssue "1" @default.
- W2781750079 hasLocation W27817500791 @default.
- W2781750079 hasOpenAccess W2781750079 @default.
- W2781750079 hasPrimaryLocation W27817500791 @default.
- W2781750079 hasRelatedWork W1492817649 @default.
- W2781750079 hasRelatedWork W2069361617 @default.
- W2781750079 hasRelatedWork W2143834136 @default.
- W2781750079 hasRelatedWork W2736735103 @default.
- W2781750079 hasRelatedWork W3015538796 @default.
- W2781750079 hasRelatedWork W3042924614 @default.
- W2781750079 hasRelatedWork W3152333724 @default.
- W2781750079 hasRelatedWork W4245718447 @default.
- W2781750079 hasRelatedWork W8621292 @default.
- W2781750079 hasRelatedWork W183359004 @default.
- W2781750079 hasVolume "218" @default.
- W2781750079 isParatext "false" @default.
- W2781750079 isRetracted "false" @default.
- W2781750079 magId "2781750079" @default.
- W2781750079 workType "article" @default.