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- W2781762092 endingPage "181" @default.
- W2781762092 startingPage "169" @default.
- W2781762092 abstract "Ultrasound-driven microbubbles can trigger reversible membrane perforation (sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing a temporary and reversible time-window for the delivery of macromolecules across biological membranes and endothelial barriers. This time-window is related not only to cavitation events, but also to biological regulatory mechanisms. Mechanistic understanding of the interaction between cavitation events and cells and tissues, as well as the subsequent cellular and molecular responses will lead to new design strategies with improved efficacy and minimized side effects. Recent important progress on the spatiotemporal characteristics of sonoporation, cavitation-induced interendothelial gap and endocytosis, and the spatiotemporal bioeffects and the preliminary biological mechanisms in cavitation-enhanced permeability, has been made. On the basis of the summary of this research progress, this Review outlines the underlying bioeffects and the related biological regulatory mechanisms involved in cavitation-enhanced permeability; provides a critical commentary on the future tasks and directions in this field, including developing a standardized methodology to reveal mechanism-based bioeffects in depth, and designing biology-based treatment strategies to improve efficacy and safety. Such mechanistic understanding the bioeffects that contribute to cavitation-enhanced delivery will accelerate the translation of this approach to the clinic." @default.
- W2781762092 created "2018-01-12" @default.
- W2781762092 creator A5043240366 @default.
- W2781762092 creator A5071289091 @default.
- W2781762092 creator A5077722406 @default.
- W2781762092 creator A5082416350 @default.
- W2781762092 date "2018-02-01" @default.
- W2781762092 modified "2023-09-30" @default.
- W2781762092 title "Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery" @default.
- W2781762092 cites W1497528220 @default.
- W2781762092 cites W1543133300 @default.
- W2781762092 cites W1574278217 @default.
- W2781762092 cites W1654653900 @default.
- W2781762092 cites W1690407338 @default.
- W2781762092 cites W1817574342 @default.
- W2781762092 cites W1841496817 @default.
- W2781762092 cites W1862606445 @default.
- W2781762092 cites W1905551819 @default.
- W2781762092 cites W1905816624 @default.
- W2781762092 cites W1918495273 @default.
- W2781762092 cites W1953757484 @default.
- W2781762092 cites W1964630494 @default.
- W2781762092 cites W1964808048 @default.
- W2781762092 cites W1965457590 @default.
- W2781762092 cites W1965734619 @default.
- W2781762092 cites W1968155437 @default.
- W2781762092 cites W1968403808 @default.
- W2781762092 cites W1969113927 @default.
- W2781762092 cites W1969786757 @default.
- W2781762092 cites W1971119618 @default.
- W2781762092 cites W1971700006 @default.
- W2781762092 cites W1972214019 @default.
- W2781762092 cites W1972788857 @default.
- W2781762092 cites W1973525513 @default.
- W2781762092 cites W1975357186 @default.
- W2781762092 cites W1976375913 @default.
- W2781762092 cites W1976679810 @default.
- W2781762092 cites W1977891925 @default.
- W2781762092 cites W1977956558 @default.
- W2781762092 cites W1978330494 @default.
- W2781762092 cites W1978550644 @default.
- W2781762092 cites W1981896615 @default.
- W2781762092 cites W1981998676 @default.
- W2781762092 cites W1984047231 @default.
- W2781762092 cites W1984928335 @default.
- W2781762092 cites W1985015502 @default.
- W2781762092 cites W1987783626 @default.
- W2781762092 cites W1989532943 @default.
- W2781762092 cites W1989569827 @default.
- W2781762092 cites W2001455415 @default.
- W2781762092 cites W2002936944 @default.
- W2781762092 cites W2003637111 @default.
- W2781762092 cites W2003736464 @default.
- W2781762092 cites W2006525925 @default.
- W2781762092 cites W2007922867 @default.
- W2781762092 cites W2008871739 @default.
- W2781762092 cites W2010081021 @default.
- W2781762092 cites W2013294072 @default.
- W2781762092 cites W2013593131 @default.
- W2781762092 cites W2013844718 @default.
- W2781762092 cites W2015892617 @default.
- W2781762092 cites W2017435508 @default.
- W2781762092 cites W2018401472 @default.
- W2781762092 cites W2021156560 @default.
- W2781762092 cites W2023713300 @default.
- W2781762092 cites W2024904424 @default.
- W2781762092 cites W2025771207 @default.
- W2781762092 cites W2026993603 @default.
- W2781762092 cites W2028434936 @default.
- W2781762092 cites W2029765361 @default.
- W2781762092 cites W2029994399 @default.
- W2781762092 cites W2030038801 @default.
- W2781762092 cites W2031151282 @default.
- W2781762092 cites W2032616438 @default.
- W2781762092 cites W2033649861 @default.
- W2781762092 cites W2034040274 @default.
- W2781762092 cites W2034231369 @default.
- W2781762092 cites W2034330513 @default.
- W2781762092 cites W2035244308 @default.
- W2781762092 cites W2036426873 @default.
- W2781762092 cites W2036805197 @default.
- W2781762092 cites W2037307064 @default.
- W2781762092 cites W2038753313 @default.
- W2781762092 cites W2038786165 @default.
- W2781762092 cites W2039167592 @default.
- W2781762092 cites W2039411165 @default.
- W2781762092 cites W2040687198 @default.
- W2781762092 cites W2040998173 @default.
- W2781762092 cites W2044266448 @default.
- W2781762092 cites W2050009085 @default.
- W2781762092 cites W2051105166 @default.
- W2781762092 cites W2051474419 @default.
- W2781762092 cites W2051549291 @default.
- W2781762092 cites W2054631938 @default.
- W2781762092 cites W2056302193 @default.
- W2781762092 cites W2056360581 @default.
- W2781762092 cites W2057081438 @default.
- W2781762092 cites W2057781911 @default.