FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781762802> ?p ?o ?g. }

• W2781762802 abstract "Amphipathic peptides with alternating polar and nonpolar amino acid sequences efficiently self-assemble into functional β-sheet fibrils as long as the nonpolar residues have sufficient hydrophobicity. For example, the Ac-(FKFE)2 -NH2 peptide rapidly self-assembles into β-sheet bilayer nanoribbons, while Ac-(AKAE)2 -NH2 fails to self-assemble under similar conditions due to the significantly reduced hydrophobicity and β-sheet propensity of Ala relative to Phe. Herein, we systematically explore the effect of substituting only two of the four Ala residues at various positions in the Ac-(AKAE)2 -NH2 peptide with amino acids of increasing hydrophobicity, β-sheet potential, and surface area (including Phe, 1-naphthylalanine (1-Nal), 2-naphthylalanine (2-Nal), cyclohexylalanine (Cha), and pentafluorophenylalanine (F5 -Phe)) on the self-assembly propensity of the resulting sequences. It was found that double Phe variants, regardless of the position of substitution, failed to self-assemble under the conditions used in this study. In contrast, all double 1-Nal and 2-Nal variants readily self-assembled, albeit at differing rates depending on the substitution patterns. To determine whether this was due to hydrophobicity or side chain surface area, we also prepared double Cha and F5 -Phe variant peptides (both side chain groups are more hydrophobic than Phe). Each of these variants also underwent effective self-assembly, with the aromatic F5 -Phe peptides doing so with greater efficiency. These findings provide insight into the role of amino acid hydrophobicity and sequence pattern on self-assembly proclivity of amphipathic peptides and on how targeted substitutions of nonpolar residues in these sequences can be exploited to tune the characteristics of the resulting self-assembled materials." @default.
• W2781762802 created "2018-01-12" @default.
• W2781762802 creator A5019990564 @default.
• W2781762802 creator A5038697003 @default.
• W2781762802 creator A5054635213 @default.
• W2781762802 date "2018-01-01" @default.
• W2781762802 modified "2023-10-03" @default.
• W2781762802 title "Balancing hydrophobicity and sequence pattern to influence self‐assembly of amphipathic peptides" @default.
• W2781762802 cites W1589545251 @default.
• W2781762802 cites W1750648095 @default.
• W2781762802 cites W1853623532 @default.
• W2781762802 cites W1952049115 @default.
• W2781762802 cites W1975069045 @default.
• W2781762802 cites W1976915573 @default.
• W2781762802 cites W1983316917 @default.
• W2781762802 cites W1988764747 @default.
• W2781762802 cites W1989059177 @default.
• W2781762802 cites W1992556206 @default.
• W2781762802 cites W1993545716 @default.
• W2781762802 cites W1996123781 @default.
• W2781762802 cites W1999466299 @default.
• W2781762802 cites W2000758416 @default.
• W2781762802 cites W2001107809 @default.
• W2781762802 cites W2001599007 @default.
• W2781762802 cites W2002364431 @default.
• W2781762802 cites W2002942766 @default.
• W2781762802 cites W2011281728 @default.
• W2781762802 cites W2019428591 @default.
• W2781762802 cites W2024855986 @default.
• W2781762802 cites W2026915312 @default.
• W2781762802 cites W2027621961 @default.
• W2781762802 cites W2028611843 @default.
• W2781762802 cites W2035824721 @default.
• W2781762802 cites W2036278706 @default.
• W2781762802 cites W2044597283 @default.
• W2781762802 cites W2044637682 @default.
• W2781762802 cites W2044884522 @default.
• W2781762802 cites W2045275890 @default.
• W2781762802 cites W2047185051 @default.
• W2781762802 cites W2047596685 @default.
• W2781762802 cites W2047745078 @default.
• W2781762802 cites W2051019873 @default.
• W2781762802 cites W2055307767 @default.
• W2781762802 cites W2057112110 @default.
• W2781762802 cites W2061014341 @default.
• W2781762802 cites W2063718726 @default.
• W2781762802 cites W2063823394 @default.
• W2781762802 cites W2064294763 @default.
• W2781762802 cites W2065546019 @default.
• W2781762802 cites W2066116579 @default.
• W2781762802 cites W2071640008 @default.
• W2781762802 cites W2075924474 @default.
• W2781762802 cites W2079040808 @default.
• W2781762802 cites W2079799830 @default.
• W2781762802 cites W2082556279 @default.
• W2781762802 cites W2084219899 @default.
• W2781762802 cites W2102137634 @default.
• W2781762802 cites W2105066593 @default.
• W2781762802 cites W2110153587 @default.
• W2781762802 cites W2132644969 @default.
• W2781762802 cites W2139598987 @default.
• W2781762802 cites W2139933057 @default.
• W2781762802 cites W2140191949 @default.
• W2781762802 cites W2140412758 @default.
• W2781762802 cites W2140888414 @default.
• W2781762802 cites W2143197682 @default.
• W2781762802 cites W2147245874 @default.
• W2781762802 cites W2147443012 @default.
• W2781762802 cites W2149298107 @default.
• W2781762802 cites W2152570401 @default.
• W2781762802 cites W2153166022 @default.
• W2781762802 cites W2157682837 @default.
• W2781762802 cites W2165531707 @default.
• W2781762802 cites W2167689349 @default.
• W2781762802 cites W2204294689 @default.
• W2781762802 cites W2211258138 @default.
• W2781762802 cites W2221862524 @default.
• W2781762802 cites W2225592990 @default.
• W2781762802 cites W2225905688 @default.
• W2781762802 cites W2239748356 @default.
• W2781762802 cites W2279818133 @default.
• W2781762802 cites W2293656855 @default.
• W2781762802 cites W2312883351 @default.
• W2781762802 cites W2316440360 @default.
• W2781762802 cites W2316837099 @default.
• W2781762802 cites W2317389586 @default.
• W2781762802 cites W2318764651 @default.
• W2781762802 cites W2318873213 @default.
• W2781762802 cites W2321162665 @default.
• W2781762802 cites W2323245805 @default.
• W2781762802 cites W2327335574 @default.
• W2781762802 cites W2337729927 @default.
• W2781762802 cites W2340955617 @default.
• W2781762802 cites W2410636706 @default.
• W2781762802 cites W2425708793 @default.
• W2781762802 cites W2426613120 @default.
• W2781762802 cites W2443671532 @default.
• W2781762802 cites W2469210687 @default.
• W2781762802 cites W2471681937 @default.
• W2781762802 cites W2508435196 @default.

• next