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- W2781767669 endingPage "763" @default.
- W2781767669 startingPage "749" @default.
- W2781767669 abstract "ABCA1 functions as a lipid transporter because it mediates the transfer of cellular phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins present in the extracellular medium. ABCA1 is a membrane PL translocase and its enzymatic activity leads to transfer of PL molecules from the cytoplasmic leaflet to the exofacial leaflet of a cell plasma membrane (PM). The presence of active ABCA1 in the PM promotes binding of apoA-I to the cell surface. About 10% of this bound apoA-I interacts directly with ABCA1 and stabilizes the transporter. Most of the pool of cell surface-associated apoA-I is bound to lipid domains in the PM that are created by the activity of ABCA1. The amphipathic α-helices in apoA-I confer detergent-like properties on the protein enabling it to solubilize PL and FC in these membrane domains to create a heterogeneous population of discoidal nascent HDL particles. This review focuses on current understanding of the structure-function relationships of human ABCA1 and the molecular mechanisms underlying HDL particle production." @default.
- W2781767669 created "2018-01-12" @default.
- W2781767669 creator A5052965419 @default.
- W2781767669 date "2018-01-01" @default.
- W2781767669 modified "2023-10-16" @default.
- W2781767669 title "Is ABCA1 a lipid transfer protein?" @default.
- W2781767669 cites W1489600500 @default.
- W2781767669 cites W151905713 @default.
- W2781767669 cites W1557332392 @default.
- W2781767669 cites W1570388980 @default.
- W2781767669 cites W1581379253 @default.
- W2781767669 cites W1901285641 @default.
- W2781767669 cites W1908587496 @default.
- W2781767669 cites W1963531905 @default.
- W2781767669 cites W1963772510 @default.
- W2781767669 cites W1965380608 @default.
- W2781767669 cites W1966690032 @default.
- W2781767669 cites W1967631017 @default.
- W2781767669 cites W1969232152 @default.
- W2781767669 cites W1971196969 @default.
- W2781767669 cites W1974176003 @default.
- W2781767669 cites W1974864595 @default.
- W2781767669 cites W1978726944 @default.
- W2781767669 cites W1978921170 @default.
- W2781767669 cites W1979560432 @default.
- W2781767669 cites W1980064899 @default.
- W2781767669 cites W1980147119 @default.
- W2781767669 cites W1981468132 @default.
- W2781767669 cites W1983491043 @default.
- W2781767669 cites W1984048380 @default.
- W2781767669 cites W1986439388 @default.
- W2781767669 cites W1986524045 @default.
- W2781767669 cites W1989242866 @default.
- W2781767669 cites W1991073529 @default.
- W2781767669 cites W1993012149 @default.
- W2781767669 cites W1993028907 @default.
- W2781767669 cites W1993447679 @default.
- W2781767669 cites W1994266499 @default.
- W2781767669 cites W1996330297 @default.
- W2781767669 cites W1998486318 @default.
- W2781767669 cites W2001777082 @default.
- W2781767669 cites W2002667410 @default.
- W2781767669 cites W2005855999 @default.
- W2781767669 cites W2007021068 @default.
- W2781767669 cites W2007363185 @default.
- W2781767669 cites W2007718055 @default.
- W2781767669 cites W2011910567 @default.
- W2781767669 cites W2014236047 @default.
- W2781767669 cites W2016399150 @default.
- W2781767669 cites W2017707639 @default.
- W2781767669 cites W2021267305 @default.
- W2781767669 cites W2022619537 @default.
- W2781767669 cites W2025043783 @default.
- W2781767669 cites W2025155898 @default.
- W2781767669 cites W2025573887 @default.
- W2781767669 cites W2025716299 @default.
- W2781767669 cites W2026358730 @default.
- W2781767669 cites W2029209271 @default.
- W2781767669 cites W2029474965 @default.
- W2781767669 cites W2030148436 @default.
- W2781767669 cites W2030319696 @default.
- W2781767669 cites W2031661692 @default.
- W2781767669 cites W2032513433 @default.
- W2781767669 cites W2036155923 @default.
- W2781767669 cites W2037303704 @default.
- W2781767669 cites W2041011601 @default.
- W2781767669 cites W2043939417 @default.
- W2781767669 cites W2044085066 @default.
- W2781767669 cites W2045263106 @default.
- W2781767669 cites W2046013039 @default.
- W2781767669 cites W2046493105 @default.
- W2781767669 cites W2046741089 @default.
- W2781767669 cites W2046797281 @default.
- W2781767669 cites W2049746692 @default.
- W2781767669 cites W2055823448 @default.
- W2781767669 cites W2056472930 @default.
- W2781767669 cites W2056761658 @default.
- W2781767669 cites W2058715043 @default.
- W2781767669 cites W2059256286 @default.
- W2781767669 cites W2059612359 @default.
- W2781767669 cites W2060181247 @default.
- W2781767669 cites W2060956030 @default.
- W2781767669 cites W2061255861 @default.
- W2781767669 cites W2064613880 @default.
- W2781767669 cites W2065263199 @default.
- W2781767669 cites W2065301785 @default.
- W2781767669 cites W2066557706 @default.
- W2781767669 cites W2067876863 @default.
- W2781767669 cites W2070060517 @default.
- W2781767669 cites W2070602012 @default.
- W2781767669 cites W2072470057 @default.
- W2781767669 cites W2072568946 @default.
- W2781767669 cites W2073410652 @default.
- W2781767669 cites W2075087933 @default.
- W2781767669 cites W2076088544 @default.
- W2781767669 cites W2077403992 @default.
- W2781767669 cites W2081198040 @default.
- W2781767669 cites W2082418166 @default.