Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781806877> ?p ?o ?g. }
- W2781806877 abstract "Hepoxilins (HXs) and trioxilins (TrXs) are involved in physiological processes such as inflammation, insulin secretion and pain perception in human. They are metabolites of polyunsaturated fatty acids (PUFAs), including arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid, formed by 12-lipoxygenase (LOX) and epoxide hydrolase (EH) expressed by mammalian cells. Here, we identify ten types of HXs and TrXs, produced by the prokaryote Myxococcus xanthus, of which six types are new, namely, HXB5, HXD3, HXE3, TrXB5, TrXD3 and TrXE3. We succeed in the biotransformation of PUFAs into eight types of HXs (>35% conversion) and TrXs (>10% conversion) by expressing M. xanthus 12-LOX or 11-LOX with or without EH in Escherichia coli. We determine 11-hydroxy-eicosatetraenoic acid, HXB3, HXB4, HXD3, TrXB3 and TrXD3 as potential peroxisome proliferator-activated receptor-γ partial agonists. These findings may facilitate physiological studies and drug development based on lipid mediators." @default.
- W2781806877 created "2018-01-12" @default.
- W2781806877 creator A5016003597 @default.
- W2781806877 creator A5017248662 @default.
- W2781806877 creator A5039448459 @default.
- W2781806877 creator A5053010626 @default.
- W2781806877 creator A5088657930 @default.
- W2781806877 creator A5091164287 @default.
- W2781806877 date "2018-01-09" @default.
- W2781806877 modified "2023-10-17" @default.
- W2781806877 title "Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes" @default.
- W2781806877 cites W103675249 @default.
- W2781806877 cites W1521475135 @default.
- W2781806877 cites W1547473925 @default.
- W2781806877 cites W1858064878 @default.
- W2781806877 cites W1858848970 @default.
- W2781806877 cites W1954693910 @default.
- W2781806877 cites W1964618518 @default.
- W2781806877 cites W1968980738 @default.
- W2781806877 cites W1975219953 @default.
- W2781806877 cites W1977087029 @default.
- W2781806877 cites W1983519362 @default.
- W2781806877 cites W1986110469 @default.
- W2781806877 cites W1996365303 @default.
- W2781806877 cites W2001752540 @default.
- W2781806877 cites W2005425288 @default.
- W2781806877 cites W2007239864 @default.
- W2781806877 cites W2007930587 @default.
- W2781806877 cites W2010746507 @default.
- W2781806877 cites W2011740189 @default.
- W2781806877 cites W2015536326 @default.
- W2781806877 cites W2018175631 @default.
- W2781806877 cites W2019698756 @default.
- W2781806877 cites W2021682044 @default.
- W2781806877 cites W2022730777 @default.
- W2781806877 cites W2023739977 @default.
- W2781806877 cites W2026662955 @default.
- W2781806877 cites W2029107666 @default.
- W2781806877 cites W2029782126 @default.
- W2781806877 cites W2031966976 @default.
- W2781806877 cites W2036154075 @default.
- W2781806877 cites W2036247576 @default.
- W2781806877 cites W2042239626 @default.
- W2781806877 cites W2047367114 @default.
- W2781806877 cites W2051620804 @default.
- W2781806877 cites W2052085748 @default.
- W2781806877 cites W2052624151 @default.
- W2781806877 cites W2053979901 @default.
- W2781806877 cites W2063065419 @default.
- W2781806877 cites W2064796825 @default.
- W2781806877 cites W2067253337 @default.
- W2781806877 cites W2071911308 @default.
- W2781806877 cites W2085121966 @default.
- W2781806877 cites W2087833884 @default.
- W2781806877 cites W2088228424 @default.
- W2781806877 cites W2095470012 @default.
- W2781806877 cites W2095524634 @default.
- W2781806877 cites W2096921659 @default.
- W2781806877 cites W2108129428 @default.
- W2781806877 cites W2112573773 @default.
- W2781806877 cites W2114578818 @default.
- W2781806877 cites W2116513829 @default.
- W2781806877 cites W2119974736 @default.
- W2781806877 cites W2129722153 @default.
- W2781806877 cites W2139002144 @default.
- W2781806877 cites W2140953825 @default.
- W2781806877 cites W2144570730 @default.
- W2781806877 cites W2154922304 @default.
- W2781806877 cites W2155905759 @default.
- W2781806877 cites W2166653277 @default.
- W2781806877 cites W2270779985 @default.
- W2781806877 cites W2296753542 @default.
- W2781806877 cites W2528606756 @default.
- W2781806877 cites W2744291240 @default.
- W2781806877 doi "https://doi.org/10.1038/s41467-017-02543-8" @default.
- W2781806877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5760719" @default.
- W2781806877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29317615" @default.
- W2781806877 hasPublicationYear "2018" @default.
- W2781806877 type Work @default.
- W2781806877 sameAs 2781806877 @default.
- W2781806877 citedByCount "27" @default.
- W2781806877 countsByYear W27818068772018 @default.
- W2781806877 countsByYear W27818068772019 @default.
- W2781806877 countsByYear W27818068772020 @default.
- W2781806877 countsByYear W27818068772021 @default.
- W2781806877 countsByYear W27818068772022 @default.
- W2781806877 countsByYear W27818068772023 @default.
- W2781806877 crossrefType "journal-article" @default.
- W2781806877 hasAuthorship W2781806877A5016003597 @default.
- W2781806877 hasAuthorship W2781806877A5017248662 @default.
- W2781806877 hasAuthorship W2781806877A5039448459 @default.
- W2781806877 hasAuthorship W2781806877A5053010626 @default.
- W2781806877 hasAuthorship W2781806877A5088657930 @default.
- W2781806877 hasAuthorship W2781806877A5091164287 @default.
- W2781806877 hasBestOaLocation W27818068771 @default.
- W2781806877 hasConcept C104317684 @default.
- W2781806877 hasConcept C127078168 @default.
- W2781806877 hasConcept C143065580 @default.
- W2781806877 hasConcept C170493617 @default.
- W2781806877 hasConcept C181199279 @default.