Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781884781> ?p ?o ?g. }
- W2781884781 endingPage "17" @default.
- W2781884781 startingPage "10" @default.
- W2781884781 abstract "As a transcription factor, autoimmune regulator (Aire) participates in thymic negative selection and maintains immune tolerance mainly by regulating the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). Aire is also expressed in dendritic cells (DCs). DCs are professional antigen-presenting cells (APCs) that affect the differentiation of T cells toward distinct subpopulations and participate in the immune response and tolerance, thereby playing an important role in maintaining homeostasis. To determine the role of Aire in maintaining immune tolerance by bone marrow-derived dendritic cells (BMDCs), in the present study we utilized Aire-knockout mice to examine the changes of maturation status and TRAs expression on BMDCs, additionally investigate the differentiation of CD4+ T cells. The results showed that expression of costimulatory molecule and major histocompatibility complex class II (MHC-II) molecule was increased and expression of various TRAs was decreased in BMDCs from Aire-knockout mice. Aire deficiency reduced the differentiation of naïve CD4+ T cells into type 2T helper (Th2) cells and regulatory T cells (Tregs) but enhanced the differentiation of naïve CD4+ T cells into Th1 cells, Th17 cells, and follicular helper T (Tfh) cells. The results demonstrate that Aire expressed by BMDCs plays an important role in the maintenance of homeostasis by regulating TRA expression and the differentiation of T cell subsets." @default.
- W2781884781 created "2018-01-12" @default.
- W2781884781 creator A5039575720 @default.
- W2781884781 creator A5043528340 @default.
- W2781884781 creator A5064117859 @default.
- W2781884781 creator A5067251286 @default.
- W2781884781 creator A5079491978 @default.
- W2781884781 creator A5082766420 @default.
- W2781884781 creator A5087831727 @default.
- W2781884781 creator A5091490854 @default.
- W2781884781 date "2018-01-02" @default.
- W2781884781 modified "2023-10-17" @default.
- W2781884781 title "Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice" @default.
- W2781884781 cites W1528831675 @default.
- W2781884781 cites W1583426224 @default.
- W2781884781 cites W1661544713 @default.
- W2781884781 cites W1687035583 @default.
- W2781884781 cites W1767255455 @default.
- W2781884781 cites W1935100605 @default.
- W2781884781 cites W1972263413 @default.
- W2781884781 cites W1980785340 @default.
- W2781884781 cites W2004282938 @default.
- W2781884781 cites W2006877529 @default.
- W2781884781 cites W2013904245 @default.
- W2781884781 cites W2014900010 @default.
- W2781884781 cites W2018703348 @default.
- W2781884781 cites W2038549421 @default.
- W2781884781 cites W2058857268 @default.
- W2781884781 cites W2058933354 @default.
- W2781884781 cites W2069545220 @default.
- W2781884781 cites W2076722399 @default.
- W2781884781 cites W2084006363 @default.
- W2781884781 cites W2098432094 @default.
- W2781884781 cites W2116763454 @default.
- W2781884781 cites W2129216405 @default.
- W2781884781 cites W2159573388 @default.
- W2781884781 cites W2165214298 @default.
- W2781884781 cites W2170209911 @default.
- W2781884781 cites W2171080847 @default.
- W2781884781 cites W2171230685 @default.
- W2781884781 cites W2266052500 @default.
- W2781884781 cites W2288606169 @default.
- W2781884781 cites W2313313242 @default.
- W2781884781 doi "https://doi.org/10.1080/08916934.2017.1422124" @default.
- W2781884781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29297233" @default.
- W2781884781 hasPublicationYear "2018" @default.
- W2781884781 type Work @default.
- W2781884781 sameAs 2781884781 @default.
- W2781884781 citedByCount "5" @default.
- W2781884781 countsByYear W27818847812018 @default.
- W2781884781 countsByYear W27818847812020 @default.
- W2781884781 countsByYear W27818847812022 @default.
- W2781884781 countsByYear W27818847812023 @default.
- W2781884781 crossrefType "journal-article" @default.
- W2781884781 hasAuthorship W2781884781A5039575720 @default.
- W2781884781 hasAuthorship W2781884781A5043528340 @default.
- W2781884781 hasAuthorship W2781884781A5064117859 @default.
- W2781884781 hasAuthorship W2781884781A5067251286 @default.
- W2781884781 hasAuthorship W2781884781A5079491978 @default.
- W2781884781 hasAuthorship W2781884781A5082766420 @default.
- W2781884781 hasAuthorship W2781884781A5087831727 @default.
- W2781884781 hasAuthorship W2781884781A5091490854 @default.
- W2781884781 hasConcept C154317977 @default.
- W2781884781 hasConcept C202751555 @default.
- W2781884781 hasConcept C203014093 @default.
- W2781884781 hasConcept C207936829 @default.
- W2781884781 hasConcept C2776090121 @default.
- W2781884781 hasConcept C2776566471 @default.
- W2781884781 hasConcept C2777702733 @default.
- W2781884781 hasConcept C2778830056 @default.
- W2781884781 hasConcept C2780007613 @default.
- W2781884781 hasConcept C2780130043 @default.
- W2781884781 hasConcept C3753494 @default.
- W2781884781 hasConcept C55493867 @default.
- W2781884781 hasConcept C67662055 @default.
- W2781884781 hasConcept C79484868 @default.
- W2781884781 hasConcept C86803240 @default.
- W2781884781 hasConcept C8891405 @default.
- W2781884781 hasConcept C95444343 @default.
- W2781884781 hasConceptScore W2781884781C154317977 @default.
- W2781884781 hasConceptScore W2781884781C202751555 @default.
- W2781884781 hasConceptScore W2781884781C203014093 @default.
- W2781884781 hasConceptScore W2781884781C207936829 @default.
- W2781884781 hasConceptScore W2781884781C2776090121 @default.
- W2781884781 hasConceptScore W2781884781C2776566471 @default.
- W2781884781 hasConceptScore W2781884781C2777702733 @default.
- W2781884781 hasConceptScore W2781884781C2778830056 @default.
- W2781884781 hasConceptScore W2781884781C2780007613 @default.
- W2781884781 hasConceptScore W2781884781C2780130043 @default.
- W2781884781 hasConceptScore W2781884781C3753494 @default.
- W2781884781 hasConceptScore W2781884781C55493867 @default.
- W2781884781 hasConceptScore W2781884781C67662055 @default.
- W2781884781 hasConceptScore W2781884781C79484868 @default.
- W2781884781 hasConceptScore W2781884781C86803240 @default.
- W2781884781 hasConceptScore W2781884781C8891405 @default.
- W2781884781 hasConceptScore W2781884781C95444343 @default.
- W2781884781 hasFunder F4320321001 @default.
- W2781884781 hasIssue "1" @default.