Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781922523> ?p ?o ?g. }
- W2781922523 endingPage "931" @default.
- W2781922523 startingPage "921" @default.
- W2781922523 abstract "Coordinated production of IFN-γ by innate and adaptive immune cells is central for host defense, but can also trigger immunopathology. The investigation of the lymphoid cell-specific contribution to the IFN-γ-mediated intestinal pathology during Toxoplasma gondii infection identified CD4+ T cells as a key cell population responsible for IFN-γ-dependent intestinal inflammation and Paneth cell loss, where T-bet-dependent group 1 innate lymphoid cells have a minor role in driving the parasite-induced immunopathology. This was evident from the analysis of T-bet deficiency that did not prevent the intestinal inflammation and instead revealed that T-bet-deficient CD4+ Th1 cells are sufficient for T. gondii-triggered acute ileitis and Paneth cell loss. These results revealed that T-bet-independent Th1 effector cells are major functional mediators of the type I immunopathological response during acute gastrointestinal infection." @default.
- W2781922523 created "2018-01-12" @default.
- W2781922523 creator A5002914011 @default.
- W2781922523 creator A5041966555 @default.
- W2781922523 creator A5042246091 @default.
- W2781922523 creator A5055493032 @default.
- W2781922523 creator A5088532366 @default.
- W2781922523 date "2018-05-01" @default.
- W2781922523 modified "2023-09-27" @default.
- W2781922523 title "T-bet-independent Th1 response induces intestinal immunopathology during Toxoplasma gondii infection" @default.
- W2781922523 cites W1483521748 @default.
- W2781922523 cites W1499307444 @default.
- W2781922523 cites W1537640495 @default.
- W2781922523 cites W1581513481 @default.
- W2781922523 cites W1585503265 @default.
- W2781922523 cites W1595949461 @default.
- W2781922523 cites W1603985409 @default.
- W2781922523 cites W1605898561 @default.
- W2781922523 cites W1618712613 @default.
- W2781922523 cites W1935228498 @default.
- W2781922523 cites W1953168141 @default.
- W2781922523 cites W1964870948 @default.
- W2781922523 cites W19656390 @default.
- W2781922523 cites W1967261754 @default.
- W2781922523 cites W1983422677 @default.
- W2781922523 cites W1984771489 @default.
- W2781922523 cites W1994875855 @default.
- W2781922523 cites W1998998882 @default.
- W2781922523 cites W2000403647 @default.
- W2781922523 cites W2002204067 @default.
- W2781922523 cites W2004869330 @default.
- W2781922523 cites W2007417265 @default.
- W2781922523 cites W2007446361 @default.
- W2781922523 cites W2017443683 @default.
- W2781922523 cites W2031029755 @default.
- W2781922523 cites W2032477135 @default.
- W2781922523 cites W2038982445 @default.
- W2781922523 cites W2047084643 @default.
- W2781922523 cites W2051465794 @default.
- W2781922523 cites W2055897422 @default.
- W2781922523 cites W2058235794 @default.
- W2781922523 cites W2078785198 @default.
- W2781922523 cites W2080316231 @default.
- W2781922523 cites W2086164999 @default.
- W2781922523 cites W2087470992 @default.
- W2781922523 cites W2109324118 @default.
- W2781922523 cites W2124254978 @default.
- W2781922523 cites W2128475635 @default.
- W2781922523 cites W2136221987 @default.
- W2781922523 cites W2140014081 @default.
- W2781922523 cites W2143286868 @default.
- W2781922523 cites W2147092388 @default.
- W2781922523 cites W2158068707 @default.
- W2781922523 cites W2164080567 @default.
- W2781922523 cites W2165394762 @default.
- W2781922523 cites W2169637734 @default.
- W2781922523 cites W2284327277 @default.
- W2781922523 cites W2412329023 @default.
- W2781922523 cites W2422180402 @default.
- W2781922523 doi "https://doi.org/10.1038/mi.2017.102" @default.
- W2781922523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6179443" @default.
- W2781922523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29297501" @default.
- W2781922523 hasPublicationYear "2018" @default.
- W2781922523 type Work @default.
- W2781922523 sameAs 2781922523 @default.
- W2781922523 citedByCount "20" @default.
- W2781922523 countsByYear W27819225232018 @default.
- W2781922523 countsByYear W27819225232019 @default.
- W2781922523 countsByYear W27819225232020 @default.
- W2781922523 countsByYear W27819225232021 @default.
- W2781922523 countsByYear W27819225232022 @default.
- W2781922523 countsByYear W27819225232023 @default.
- W2781922523 crossrefType "journal-article" @default.
- W2781922523 hasAuthorship W2781922523A5002914011 @default.
- W2781922523 hasAuthorship W2781922523A5041966555 @default.
- W2781922523 hasAuthorship W2781922523A5042246091 @default.
- W2781922523 hasAuthorship W2781922523A5055493032 @default.
- W2781922523 hasAuthorship W2781922523A5088532366 @default.
- W2781922523 hasBestOaLocation W27819225231 @default.
- W2781922523 hasConcept C136449434 @default.
- W2781922523 hasConcept C142724271 @default.
- W2781922523 hasConcept C159654299 @default.
- W2781922523 hasConcept C193419808 @default.
- W2781922523 hasConcept C203014093 @default.
- W2781922523 hasConcept C2776090121 @default.
- W2781922523 hasConcept C2776914184 @default.
- W2781922523 hasConcept C2778128430 @default.
- W2781922523 hasConcept C2779134260 @default.
- W2781922523 hasConcept C2779280984 @default.
- W2781922523 hasConcept C2780648854 @default.
- W2781922523 hasConcept C2780941987 @default.
- W2781922523 hasConcept C2908647359 @default.
- W2781922523 hasConcept C51785407 @default.
- W2781922523 hasConcept C71924100 @default.
- W2781922523 hasConcept C86803240 @default.
- W2781922523 hasConcept C8891405 @default.
- W2781922523 hasConcept C99454951 @default.
- W2781922523 hasConceptScore W2781922523C136449434 @default.