FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781964343> ?p ?o ?g. }

• W2781964343 endingPage "8511" @default.
• W2781964343 startingPage "8502" @default.
• W2781964343 abstract "// Min-Hua Tseng 1 , Shih-Hua Lin 2 , Chao-Yi Wu 3 , Hui-Ping Chien 4 , Huang-Yu Yang 5 , Yung-Chang Chen 5 , Yu-Ching Chou 6 and Jing-Long Huang 3 1 Division of Nephrology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan 2 Division of Nephrology, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan 3 Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan 4 Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan 5 Department of Nephrology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan 6 School of Public Health, National Defense Medical Center, Taipei, Taiwan Correspondence to: Jing-Long Huang, email: long@adm.cgmh.org Keywords: systemic lupus erythematosus; disease activity; complement regulatory proteins; lupus nephritis; biomarker Received: July 12, 2017      Accepted: October 30, 2017      Published: January 03, 2018 ABSTRACT Although aberrant complement activation is involved in the pathogenesis of systemic lupus erythematosus (SLE), the role of complement regulatory proteins in disease activity of SLE remains limited. We enrolled the pediatric-onset SLE patients from our cohort study over 10 years. The clinical and laboratory data including SLEDAI disease activity score, and serum complement factor H (CFH), CFI, CD46, C5a, and C5b-9 in the active and remission phases were determined. Glomerular C5b-9 deposition as a complement activity marker was also examined. Forty patients (35 female and 5 male, aged 13.9 ± 3.8 years) met the criteria of investigation were assessed. Fever and kidney were the most common symptom and organ involved, respectively. Mean SLEDAI in the active and remission phases were 12.6 vs 1.7, respectively. All patients exhibited lower serum C3, C4, CFH and CFI and higher serum anti-dsDNA and CD46 in the active pahse. There was a significant difference in serum CFH, CFI and CD46 between active and remissive phases. Serum CFI but not CFH and CD46 level was negatively correlated with SLEDAI score in active phase. Compared to classical activity markers, serum CFI was superior to C4 and anti-dsDNA in reflecting disease activity and also significantly correlated with white blood count and hemoglobin. Glomerular C5b-9 depositions were detected in patients with nephritis during active phase but not in disease controls. Serum CFI level may not only be a promising biomarker for disease activity of SLE, but also reflects the hematological features of SLE." @default.
• W2781964343 created "2018-01-12" @default.
• W2781964343 creator A5016348471 @default.
• W2781964343 creator A5016470107 @default.
• W2781964343 creator A5023025863 @default.
• W2781964343 creator A5038756897 @default.
• W2781964343 creator A5043569131 @default.
• W2781964343 creator A5065041140 @default.
• W2781964343 creator A5074241993 @default.
• W2781964343 creator A5078681943 @default.
• W2781964343 date "2018-01-03" @default.
• W2781964343 modified "2023-09-27" @default.
• W2781964343 title "Serum complement factor I is associated with disease activity of systemic lupus erythematosus" @default.
• W2781964343 cites W1574593386 @default.
• W2781964343 cites W1974174091 @default.
• W2781964343 cites W1984019715 @default.
• W2781964343 cites W1997599954 @default.
• W2781964343 cites W2003048916 @default.
• W2781964343 cites W2025998055 @default.
• W2781964343 cites W2051697614 @default.
• W2781964343 cites W2060179486 @default.
• W2781964343 cites W2064999867 @default.
• W2781964343 cites W2070527591 @default.
• W2781964343 cites W2072353833 @default.
• W2781964343 cites W2089507112 @default.
• W2781964343 cites W2095409772 @default.
• W2781964343 cites W2097046783 @default.
• W2781964343 cites W2097465080 @default.
• W2781964343 cites W2111940985 @default.
• W2781964343 cites W2112324202 @default.
• W2781964343 cites W2114842362 @default.
• W2781964343 cites W2118510193 @default.
• W2781964343 cites W2126682268 @default.
• W2781964343 cites W2137304121 @default.
• W2781964343 cites W2145572391 @default.
• W2781964343 cites W2146203649 @default.
• W2781964343 cites W2315112971 @default.
• W2781964343 cites W2317673636 @default.
• W2781964343 cites W2397057957 @default.
• W2781964343 cites W2415441778 @default.
• W2781964343 cites W2470805237 @default.
• W2781964343 cites W2528995581 @default.
• W2781964343 cites W2592083651 @default.
• W2781964343 doi "https://doi.org/10.18632/oncotarget.23907" @default.
• W2781964343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5823600" @default.
• W2781964343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29492211" @default.
• W2781964343 hasPublicationYear "2018" @default.
• W2781964343 type Work @default.
• W2781964343 sameAs 2781964343 @default.
• W2781964343 citedByCount "12" @default.
• W2781964343 countsByYear W27819643432019 @default.
• W2781964343 countsByYear W27819643432020 @default.
• W2781964343 countsByYear W27819643432021 @default.
• W2781964343 countsByYear W27819643432022 @default.
• W2781964343 countsByYear W27819643432023 @default.
• W2781964343 crossrefType "journal-article" @default.
• W2781964343 hasAuthorship W2781964343A5016348471 @default.
• W2781964343 hasAuthorship W2781964343A5016470107 @default.
• W2781964343 hasAuthorship W2781964343A5023025863 @default.
• W2781964343 hasAuthorship W2781964343A5038756897 @default.
• W2781964343 hasAuthorship W2781964343A5043569131 @default.
• W2781964343 hasAuthorship W2781964343A5065041140 @default.
• W2781964343 hasAuthorship W2781964343A5074241993 @default.
• W2781964343 hasAuthorship W2781964343A5078681943 @default.
• W2781964343 hasBestOaLocation W27819643431 @default.
• W2781964343 hasConcept C126322002 @default.
• W2781964343 hasConcept C198451711 @default.
• W2781964343 hasConcept C203014093 @default.
• W2781964343 hasConcept C2779134260 @default.
• W2781964343 hasConcept C2779912601 @default.
• W2781964343 hasConcept C54847362 @default.
• W2781964343 hasConcept C71924100 @default.
• W2781964343 hasConceptScore W2781964343C126322002 @default.
• W2781964343 hasConceptScore W2781964343C198451711 @default.
• W2781964343 hasConceptScore W2781964343C203014093 @default.
• W2781964343 hasConceptScore W2781964343C2779134260 @default.
• W2781964343 hasConceptScore W2781964343C2779912601 @default.
• W2781964343 hasConceptScore W2781964343C54847362 @default.
• W2781964343 hasConceptScore W2781964343C71924100 @default.
• W2781964343 hasIssue "9" @default.
• W2781964343 hasLocation W27819643431 @default.
• W2781964343 hasLocation W27819643432 @default.
• W2781964343 hasLocation W27819643433 @default.
• W2781964343 hasLocation W27819643434 @default.
• W2781964343 hasOpenAccess W2781964343 @default.
• W2781964343 hasPrimaryLocation W27819643431 @default.
• W2781964343 hasRelatedWork W16884040 @default.
• W2781964343 hasRelatedWork W1847058334 @default.
• W2781964343 hasRelatedWork W1979907091 @default.
• W2781964343 hasRelatedWork W1993116843 @default.
• W2781964343 hasRelatedWork W2017621001 @default.
• W2781964343 hasRelatedWork W2622204852 @default.
• W2781964343 hasRelatedWork W2808229450 @default.
• W2781964343 hasRelatedWork W3019617120 @default.
• W2781964343 hasRelatedWork W3032477310 @default.
• W2781964343 hasRelatedWork W4311672243 @default.
• W2781964343 hasVolume "9" @default.
• W2781964343 isParatext "false" @default.

• next