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• W2781977401 abstract "// Zhilan Chen 1, * , Yingyan Han 2, * , Chengwen Song 1 , Huafang Wei 1 , Ying Chen 1 , Kecheng Huang 2 , Shuang Li 2 , Ding Ma 2 , Shixuan Wang 2 , Jing Wang 1 and Qiping Lu 3 1 Department of Obstetrics and Gynecology, Wuhan General Hospital of People’s Liberation Army of China, Wuhan, Hubei, China 2 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China 3 Department of General Surgery, Wuhan General Hospital of People’s Liberation Army of China, Wuhan, Hubei, China * These authors contributed equally to this work Correspondence to: Jing Wang, email: jingwang198723@163.com Qiping Lu, email: ptwklqp111@163.com Keywords: cervical cancer; miRNA; prognosis; meta-analysis Received: February 03, 2017      Accepted: October 05, 2017      Epub: December 16, 2017      Published: March 30, 2018 ABSTRACT In this meta-analysis, we analyzed case-control studies that assessed the prognostic potential of miRNAs in cervical cancer. We comprehensively searched EMBASE and PubMed databases and enrolled seven studies with 445 cervical cancer cases. A fixed effects model was used to calculate pooled hazard ratios (HRs) and associated 95% confidence intervals (95% CIs) from the overall survival (OS) data. Our analysis showed that poor OS in cervical cancer was associated with low miR-125 expression (HR = 1.61, 95% CI: 1.02–2.55, P = 0.042; I 2 = 10.1%, P = 0.292; n = 99), low miR-145 expression (HR = 1.70, 95% CI: 1.29–2.24, P < 0.001; I 2 = 0%, P = 0.560; n = 193) and high miR-196 expression (HR = 0.28, 95% CI: 0.15–0.52, P < 0.001; I 2 = 0%, P = 0.950, n = 197). This makes microRNAs such as miR-125, miR-145 and miR-196 potential prognostic biomarkers in cervical cancer." @default.
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• W2781977401 date "2017-12-16" @default.
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• W2781977401 title "Systematic review and meta-analysis of the prognostic significance of microRNAs in cervical cancer" @default.
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• W2781977401 doi "https://doi.org/10.18632/oncotarget.23839" @default.
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